{"id":15758,"date":"2022-01-03T02:28:01","date_gmt":"2022-01-02T23:28:01","guid":{"rendered":"https:\/\/zdmaa.com\/immunotherapy-represents-progress-in-cancer-treatment\/"},"modified":"2022-01-04T12:31:38","modified_gmt":"2022-01-04T09:31:38","slug":"immunotherapy-represents-progress-in-cancer-treatment","status":"publish","type":"post","link":"https:\/\/zdmaa.com\/fr\/immunotherapy-represents-progress-in-cancer-treatment\/","title":{"rendered":"L’immunoth\u00e9rapie repr\u00e9sente une avanc\u00e9e dans le traitement du cancer"},"content":{"rendered":"

L’immunoth\u00e9rapie repr\u00e9sente une avanc\u00e9e dans le traitement du cancer<\/span><\/span><\/span><\/span><\/p>\n

\n

Notre syst\u00e8me immunitaire n’a qu’un seul but : se prot\u00e9ger des maladies. <\/span>Cependant, certains types de cancer peuvent submerger notre syst\u00e8me immunitaire et les cellules canc\u00e9reuses peuvent se multiplier malgr\u00e9 tous les efforts de notre corps. <\/span>Heureusement, les chercheurs ont d\u00e9velopp\u00e9 une nouvelle classe de m\u00e9dicaments appel\u00e9e immunoth\u00e9rapie, qui peut aider un syst\u00e8me immunitaire silencieux \u00e0 combattre le cancer.<\/span><\/span><\/p>\n

L’immunoth\u00e9rapie a \u00e9t\u00e9 pr\u00e9sent\u00e9e dans la revue <\/span><\/span>Science<\/span><\/span><\/em> comme la plus grande perc\u00e9e scientifique de 2013. Nous sommes \u00e0 un point de basculement \u00ab\u00a0les efforts attendus depuis longtemps pour lib\u00e9rer le syst\u00e8me immunitaire contre les tumeurs portent leurs fruits\u00a0\u00bb avec un nombre croissant de r\u00e9ussites de patients, ont d\u00e9clar\u00e9 les \u00e9diteurs. . <\/span>Les m\u00e9dicaments d’immunoth\u00e9rapie agissent en stimulant certaines parties du syst\u00e8me immunitaire ou en neutralisant les signaux des cellules canc\u00e9reuses qui bloquent la r\u00e9ponse immunitaire.<\/span><\/span><\/p>\n

L’id\u00e9e d’exploiter notre syst\u00e8me immunitaire pour traiter le cancer remonte \u00e0 la fin du XIXe si\u00e8cle, lorsque le Dr William Cooley, un chirurgien new-yorkais, a d\u00e9couvert que les tumeurs de certains patients canc\u00e9reux r\u00e9tr\u00e9cissaient si le patient d\u00e9veloppait une infection apr\u00e8s la chirurgie. <\/span>Cooley a d\u00e9velopp\u00e9 une m\u00e9thode d’induction de fi\u00e8vre pour stimuler une r\u00e9ponse immunitaire, mais son approche a \u00e9t\u00e9 abandonn\u00e9e lorsqu’il a commenc\u00e9 la radioth\u00e9rapie.<\/span><\/span><\/p>\n

La recherche sur l’immunoth\u00e9rapie a consid\u00e9rablement augment\u00e9 entre le milieu et la fin du vingti\u00e8me si\u00e8cle. <\/span>Apr\u00e8s des centaines d’essais cliniques et de nombreuses heures en laboratoire, les chercheurs commencent \u00e0 identifier les m\u00e9canismes qui feraient fonctionner l’immunoth\u00e9rapie. <\/span>L’une des plus grandes d\u00e9couvertes a \u00e9t\u00e9 la d\u00e9couverte que certaines mol\u00e9cules des cellules T \u00e9taient d\u00e9sactiv\u00e9es lorsqu’elles rencontraient des cellules canc\u00e9reuses. <\/span>Des chercheurs ont mis au point des m\u00e9dicaments pour emp\u00eacher ces mol\u00e9cules de s’arr\u00eater et pour maintenir le syst\u00e8me immunitaire en activit\u00e9.<\/span><\/span><\/p>\n

En 2011, la Food and Drug Administration a approuv\u00e9 le premier m\u00e9dicament d’immunoth\u00e9rapie \u00ab\u00a0inhibiteur de point de contr\u00f4le\u00a0\u00bb, l’ipilimumab (Yervoy\u00ae), pour le m\u00e9lanome avanc\u00e9 et m\u00e9tastatique. <\/span>D’autres m\u00e9dicaments fonctionnent de mani\u00e8re similaire, mais ils ciblent des mol\u00e9cules diff\u00e9rentes. <\/span>Le pembrolizumab (Keytruda\u00ae) cible la prot\u00e9ine de mort programm\u00e9e 1 (PD-1) trouv\u00e9e dans les cellules T et a \u00e9t\u00e9 r\u00e9cemment approuv\u00e9 par la Food and Drug Administration des \u00c9tats-Unis pour le traitement du m\u00e9lanome avanc\u00e9 et est \u00e0 l’\u00e9tude dans d’autres types de cancer. <\/span>Nivolumab (Opdivo\u00ae) est efficace pour certains patients atteints de cancer de la peau, ainsi que pour les patients atteints de cancer du rein et de cancer du poumon non \u00e0 petites cellules.<\/span><\/span><\/p>\n

Les inhibiteurs de point de contr\u00f4le ne sont qu’un type de m\u00e9dicament dans une large classe d’immunoth\u00e9rapies, qui comprennent \u00e9galement\u00a0:<\/span><\/span><\/p>\n

Vaccins <\/span>contre le cancer : les<\/span><\/strong> vaccins utilis\u00e9s pour aider \u00e0 pr\u00e9venir ou \u00e0 traiter le cancer sont des substances inject\u00e9es qui activent la r\u00e9ponse immunitaire contre certaines maladies. <\/span>Sipuleucel-T (Provenge\u00ae) est le seul vaccin approuv\u00e9 par la FDA pour le traitement du cancer, en particulier du cancer avanc\u00e9 de la prostate qui a cess\u00e9 de r\u00e9pondre \u00e0 l’hormonoth\u00e9rapie. <\/span>Gardasil\u00ae, Gardasil 9\u00ae et Cervarix\u00ae sont des vaccins pr\u00e9ventifs contre le cancer du col de l’ut\u00e9rus.<\/span><\/span><\/p>\n

Cytokines :<\/span><\/span><\/strong> Ces prot\u00e9ines se trouvent naturellement dans notre corps en petites quantit\u00e9s et agissent comme des messagers pour envoyer des signaux au syst\u00e8me immunitaire. <\/span>Par exemple, une cytokine connue sous le nom d’interleukine-2 est disponible via le m\u00e9dicament Desleukin\u00ae (Proleukin\u00ae) en quantit\u00e9s beaucoup plus importantes que ce que notre corps peut produire. <\/span>Le m\u00e9dicament aide le corps \u00e0 fabriquer des cellules immunitaires suraliment\u00e9es qui tuent le cancer. <\/span>L’aldesleucine est approuv\u00e9e par la FDA pour les patients atteints de cancer du rein m\u00e9tastatique et de m\u00e9lanome m\u00e9tastatique.<\/span><\/span><\/p>\n

En savoir plus sur la m\u00e9decine de pr\u00e9cision.<\/span><\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

L’immunoth\u00e9rapie repr\u00e9sente une avanc\u00e9e dans le traitement du cancer Notre syst\u00e8me immunitaire n’a qu’un seul but : se prot\u00e9ger des maladies. Cependant, certains types de cancer peuvent submerger notre syst\u00e8me immunitaire et les cellules canc\u00e9reuses peuvent se multiplier malgr\u00e9 tous les efforts de notre corps. Heureusement, les chercheurs ont d\u00e9velopp\u00e9 une nouvelle classe de m\u00e9dicaments …<\/p>\n","protected":false},"author":1,"featured_media":14781,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-15758","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-non-classifiee"],"yoast_head":"\nL'immunoth\u00e9rapie repr\u00e9sente une avanc\u00e9e dans le traitement du cancer - zdmaa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zdmaa.com\/fr\/immunotherapy-represents-progress-in-cancer-treatment\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"L'immunoth\u00e9rapie repr\u00e9sente une avanc\u00e9e dans le traitement du cancer - zdmaa\" \/>\n<meta property=\"og:description\" content=\"L’immunoth\u00e9rapie repr\u00e9sente une avanc\u00e9e dans le traitement du cancer Notre syst\u00e8me immunitaire n’a qu’un seul but : se prot\u00e9ger des maladies. 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