{"id":16705,"date":"2022-01-05T20:30:40","date_gmt":"2022-01-05T17:30:40","guid":{"rendered":"https:\/\/zdmaa.com\/genetic-testing-may-identify-personalized-therapies\/"},"modified":"2022-01-05T21:06:51","modified_gmt":"2022-01-05T18:06:51","slug":"genetic-testing-may-identify-personalized-therapies","status":"publish","type":"post","link":"https:\/\/zdmaa.com\/fr\/genetic-testing-may-identify-personalized-therapies\/","title":{"rendered":"Les tests g\u00e9n\u00e9tiques peuvent identifier des traitements personnalis\u00e9s"},"content":{"rendered":"

Les tests g\u00e9n\u00e9tiques peuvent identifier des traitements personnalis\u00e9s<\/span><\/span><\/span><\/span><\/p>\n

\n

Vous \u00eates-vous d\u00e9j\u00e0 demand\u00e9 pourquoi un m\u00e9dicament fonctionne pour un patient et pas pour un autre ? <\/span>La r\u00e9ponse r\u00e9side peut-\u00eatre dans la pharmacog\u00e9nomique. <\/span>Ce domaine en pleine croissance de la m\u00e9decine personnalis\u00e9e \u00e9tudie comment la constitution g\u00e9n\u00e9tique unique d’une personne affecte sa r\u00e9ponse aux m\u00e9dicaments et aux drogues.<\/span><\/span><\/p>\n

\u00ab Tout comme nos g\u00e8nes d\u00e9terminent le groupe sanguin et la couleur des yeux, ils sont en partie responsables de la fa\u00e7on dont notre corps r\u00e9agit aux m\u00e9dicaments \u00bb, explique Murray Markman, MD, chef de la m\u00e9decine et de la science aux Cancer Treatment Centers of America. <\/span><\/span>\u00ae<\/span><\/span><\/sup> (CTCA). <\/span>\u00ab\u00a0La pharmacog\u00e9nomique recherche des changements dans ces g\u00e8nes qui peuvent d\u00e9terminer si un m\u00e9dicament pourrait \u00eatre un traitement viable ou provoquer des effets secondaires sp\u00e9cifiques.\u00a0\u00bb<\/span><\/span><\/p>\n

Facteurs g\u00e9n\u00e9tiques et traitements pharmacologiques.<\/span><\/span><\/h2>\n

Le domaine d’\u00e9tude consiste \u00e0 tester le g\u00e9notypage pour voir comment les patients peuvent traiter une vari\u00e9t\u00e9 de m\u00e9dicaments, y compris les traitements contre le cancer. <\/span>Les diff\u00e9rences entre les individus peuvent affecter l’absorption, le m\u00e9tabolisme ou l’activit\u00e9 d’un m\u00e9dicament. <\/span>\u00ab\u00a0La seule fa\u00e7on de traiter le cancer est en train de devenir une chose du pass\u00e9\u00a0\u00bb, d\u00e9clare le Dr Markman. <\/span>\u00ab\u00a0Il est remplac\u00e9 par des m\u00e9dicaments et des traitements qui ciblent directement l’ADN individuel d’un patient.\u00a0\u00bb<\/span><\/span><\/p>\n

Actuellement, les m\u00e9decins fondent la plupart de leurs prescriptions sur des facteurs cliniques, tels que le stade du cancer et l’\u00e2ge et le sexe du patient. <\/span>Mais la g\u00e9n\u00e9tique d’une personne peut \u00eatre tout aussi importante que les facteurs cliniques. <\/span>Pour un petit sous-ensemble de m\u00e9dicaments, les chercheurs ont identifi\u00e9 des diff\u00e9rences g\u00e9n\u00e9tiques qui affectent la fa\u00e7on dont les gens r\u00e9agissent. <\/span>Dans ces cas, les cliniciens peuvent utiliser les informations pharmacog\u00e9nomiques pour choisir le m\u00e9dicament le plus susceptible de fonctionner et pour identifier les personnes qui ont besoin d’une dose inhabituellement \u00e9lev\u00e9e ou faible.<\/span><\/span><\/p>\n

La Food and Drug Administration des \u00c9tats-Unis, qui surveille la s\u00e9curit\u00e9 de tous les m\u00e9dicaments aux \u00c9tats-Unis, a inclus des informations g\u00e9n\u00e9tiques sur les m\u00e9dicaments sur les \u00e9tiquettes de plus de 150 m\u00e9dicaments. <\/span>Ces informations, qui peuvent couvrir les recommandations posologiques, les effets secondaires potentiels ou les diff\u00e9rences d’efficacit\u00e9 pour les personnes pr\u00e9sentant certaines diff\u00e9rences g\u00e9n\u00e9tiques, peuvent aider les cliniciens \u00e0 adapter leurs prescriptions de m\u00e9dicaments \u00e0 chaque patient.<\/span><\/span><\/p>\n

Fronti\u00e8res de la pharmacog\u00e9nomique<\/span><\/span><\/h2>\n

Mais il y a des limites. <\/span>La pharmacog\u00e9nomique ne fournit pas d’informations sur la fa\u00e7on dont les patients r\u00e9agissent \u00e0 tous les m\u00e9dicaments. <\/span>Certains peuvent avoir besoin de plus d’un test s’ils prennent plus d’un type de m\u00e9dicament. <\/span>\u00ab\u00a0Les tests ne sont pas une boule de cristal. Ils ne peuvent pas d\u00e9terminer le m\u00e9dicament id\u00e9al pour votre \u00e9tat ou fournir des informations sur les interactions m\u00e9dicamenteuses\u00a0\u00bb, explique le Dr Markman. <\/span>\u00ab\u00a0Alternativement, les tests de pharmacog\u00e9nomique peuvent affiner vos options et aider les cliniciens \u00e0 prescrire le bon m\u00e9dicament plus rapidement.\u00a0\u00bb<\/span><\/span><\/p>\n

Bien que l’utilisation de la pharmacog\u00e9nomique soit limit\u00e9e, de nouvelles approches sont \u00e0 l’\u00e9tude dans des essais cliniques. <\/span>L’objectif ultime est de d\u00e9velopper des tests qui m\u00e8neront au d\u00e9veloppement de m\u00e9dicaments personnalis\u00e9s pour traiter un large \u00e9ventail de probl\u00e8mes de sant\u00e9, y compris diff\u00e9rents types de cancer. <\/span>\u00ab La m\u00e9decine de pr\u00e9cision dans le traitement du cancer se d\u00e9veloppe \u00e0 un rythme rapide \u00bb, d\u00e9clare le Dr Markman. <\/span>\u00ab\u00a0La pharmacog\u00e9nomique devrait \u00e9galement devenir plus standard \u00e0 mesure que la m\u00e9decine de pr\u00e9cision devient de plus en plus populaire.\u00a0\u00bb<\/span><\/span><\/p>\n

En savoir plus sur le traitement pr\u00e9cis du cancer.<\/span><\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Les tests g\u00e9n\u00e9tiques peuvent identifier des traitements personnalis\u00e9s Vous \u00eates-vous d\u00e9j\u00e0 demand\u00e9 pourquoi un m\u00e9dicament fonctionne pour un patient et pas pour un autre ? La r\u00e9ponse r\u00e9side peut-\u00eatre dans la pharmacog\u00e9nomique. Ce domaine en pleine croissance de la m\u00e9decine personnalis\u00e9e \u00e9tudie comment la constitution g\u00e9n\u00e9tique unique d’une personne affecte sa r\u00e9ponse aux m\u00e9dicaments et …<\/p>\n","protected":false},"author":1,"featured_media":16689,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-16705","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-non-classifiee"],"yoast_head":"\nLes tests g\u00e9n\u00e9tiques peuvent identifier des traitements personnalis\u00e9s - zdmaa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zdmaa.com\/fr\/genetic-testing-may-identify-personalized-therapies\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Les tests g\u00e9n\u00e9tiques peuvent identifier des traitements personnalis\u00e9s - zdmaa\" \/>\n<meta property=\"og:description\" content=\"Les tests g\u00e9n\u00e9tiques peuvent identifier des traitements personnalis\u00e9s Vous \u00eates-vous d\u00e9j\u00e0 demand\u00e9 pourquoi un m\u00e9dicament fonctionne pour un patient et pas pour un autre ? 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