{"id":15207,"date":"2022-01-03T16:47:06","date_gmt":"2022-01-03T13:47:06","guid":{"rendered":"https:\/\/zdmaa.com\/how-do-glioblastomas-hide-from-the-immune-system\/"},"modified":"2022-01-03T21:24:56","modified_gmt":"2022-01-03T18:24:56","slug":"how-do-glioblastomas-hide-from-the-immune-system","status":"publish","type":"post","link":"https:\/\/zdmaa.com\/tr\/how-do-glioblastomas-hide-from-the-immune-system\/","title":{"rendered":"Glioblastomlar ba\u011f\u0131\u015f\u0131kl\u0131k sisteminden nas\u0131l kaybolur?"},"content":{"rendered":"

Glioblastomlar ba\u011f\u0131\u015f\u0131kl\u0131k sisteminden nas\u0131l kaybolur?<\/span><\/span><\/span><\/span><\/p>\n

\n

T\u00fcm kanser h\u00fccreleri zararl\u0131d\u0131r, ancak \u00e7ok az\u0131 bir beyin kanseri t\u00fcr\u00fc olan glioblastomay\u0131 olu\u015fturanlar kadar agresif ve istilac\u0131 davran\u0131r. <\/span>Yeni ara\u015ft\u0131rmalar \u015fimdi glioblastoma h\u00fccrelerinin v\u00fccudun ba\u011f\u0131\u015f\u0131kl\u0131k sisteminden nas\u0131l sakland\u0131\u011f\u0131na dair ipu\u00e7lar\u0131 sa\u011flayarak bilim adamlar\u0131na fikirlerin daha do\u011fru te\u015fhislere ve daha iyi tedavi se\u00e7eneklerine yol a\u00e7abilece\u011fini umuyor.<\/span><\/span><\/p>\n

T\u00fcm kanserler gibi, glioblastomlar da mutasyona u\u011frayan ve tehlikeli hale gelen, ani ve h\u0131zl\u0131 bir sald\u0131r\u0131yla beynin alanlar\u0131n\u0131 ele ge\u00e7iren v\u00fccudun ayn\u0131 h\u00fccreleridir. <\/span>H\u0131zla b\u00fcy\u00fcrler, \u00e7oklu mutasyonlar yarat\u0131rlar, sinyal yollar\u0131 olu\u015ftururlar ve sa\u011fl\u0131kl\u0131 h\u00fccreleri takviye olarak toplarlar. <\/span>Bu h\u00fccreler bir kez yerle\u015ftikten sonra, bulmak veya ortadan kald\u0131rmak genellikle zordur. <\/span>Ameliyat ge\u00e7ici olarak i\u015fe yarayabilir, ancak bu t\u00fcm\u00f6rler glial h\u00fccrelerden (merkezi sinir sisteminde bulunan bir h\u00fccre t\u00fcr\u00fc) yap\u0131ld\u0131\u011f\u0131ndan, genellikle beyin dokusu i\u00e7inde ve cerrah\u0131n eri\u015femeyece\u011fi bir yerde saklan\u0131rlar. <\/span>Kemoterapi, radyasyon ve baz\u0131 hedefe y\u00f6nelik tedaviler genellikle istilay\u0131 durdurmak veya yava\u015flatmak i\u00e7in kullan\u0131l\u0131r.<\/span><\/span><\/p>\n

Glioblastomlar nelerdir?<\/span><\/span><\/h2>\n

Glioblastoma, beyin, beyin sap\u0131 veya merkezi sinir sistemi t\u00fcm\u00f6r\u00fc olan bir glioman\u0131n IV. derece versiyonudur. <\/span>T\u00fcm\u00f6rler genellikle ba\u015f a\u011fr\u0131s\u0131, ba\u015f d\u00f6nmesi veya mide bulant\u0131s\u0131, g\u00f6rme veya konu\u015fma g\u00fc\u00e7l\u00fc\u011f\u00fc ve\/veya n\u00f6betler gibi bir tak\u0131m semptomlar g\u00f6sterir. <\/span>Bu t\u00fcm\u00f6rlere, olu\u015fturduklar\u0131 y\u0131ld\u0131z \u015feklindeki glial h\u00fccrelere g\u00f6re bazen astrositomlar denir. <\/span>Ara\u015ft\u0131rmac\u0131lar, glioblastomun nas\u0131l ve neden olu\u015ftu\u011funu hen\u00fcz belirlemedi. <\/span>Chicago yak\u0131nlar\u0131ndaki hastanemizde t\u0131bbi onkolog olan Laura Farrington, “Baz\u0131lar\u0131 g\u00fc\u00e7l\u00fc bir \u015fekilde ba\u015fl\u0131yor ve b\u00fcy\u00fcmeye devam ediyor” diyor. <\/span>“Baz\u0131lar\u0131 iyi huylu t\u00fcm\u00f6rler olarak ba\u015fl\u0131yor. Ve y\u0131llar i\u00e7inde onlar\u0131 daha agresif yapan daha fazla mutasyon kazan\u0131yorlar.” <\/span>Son zamanlarda yap\u0131lan baz\u0131 ara\u015ft\u0131rmalar, bu haydut h\u00fccrelerin nas\u0131l ve neden bu kadar \u00e7arp\u0131k ve y\u0131k\u0131c\u0131 hale geldi\u011fine yeni bir \u0131\u015f\u0131k tuttu.<\/span><\/span><\/p>\n

\u0130sve\u00e7’teki ara\u015ft\u0131rmac\u0131lar, glioblastomun ba\u011f\u0131\u015f\u0131kl\u0131k sistemini atlamas\u0131 i\u00e7in bir yol ke\u015ffettiklerine inan\u0131yorlar. <\/span>Bu y\u0131l yay\u0131nlanan bir ara\u015ft\u0131rman\u0131n sonu\u00e7lar\u0131nda bilim adamlar\u0131, glioblastoma h\u00fccrelerinin beyindeki ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccreleri olan mikroglia ile ileti\u015fim kurmak i\u00e7in bir sinyal yolu olu\u015fturdu\u011fu sonucuna vard\u0131. <\/span>\u00c7al\u0131\u015fman\u0131n ba\u015f yazar\u0131 Bertrand Joseph, sinyalin mikrogliay\u0131 normal bir koruyucu proteini bloke etmesi i\u00e7in kand\u0131rd\u0131\u011f\u0131n\u0131 ve “kanser h\u00fccrelerine sald\u0131rmak yerine onlar\u0131 uyarmas\u0131na” yol a\u00e7t\u0131\u011f\u0131n\u0131 s\u00f6yledi. <\/span><\/span>G\u00fcnl\u00fck bilim<\/span><\/span><\/em> . <\/span>Asl\u0131nda, <\/span>Journal of Clinical Research<\/span><\/em> taraf\u0131ndan bu y\u0131l yay\u0131nlanan bir makaleye g\u00f6re, glioblastomlar\u0131n bazen ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccreleriyle y\u00fckl\u00fc oldu\u011fu bulunmu\u015ftur <\/span><\/span>.<\/span><\/span><\/em>. <\/span>Ancak bir\u00e7ok kanser h\u00fccresinde oldu\u011fu gibi, glioblastoma h\u00fccreleri de ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccrelerini toplaman\u0131n, \u00f6nlemenin veya daha az etkili hale getirmenin yollar\u0131n\u0131 bulur. <\/span>Ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccrelerini \u00e7e\u015fitli kanserlere kar\u015f\u0131 uyaran umut verici bir tedavi olan imm\u00fcnoterapinin, glioblastomalara kar\u015f\u0131 yararl\u0131 oldu\u011fu hen\u00fcz g\u00f6sterilmemi\u015ftir.<\/span><\/span><\/p>\n

Glioblastoma nas\u0131l tedavi edilir?<\/span><\/span><\/h2>\n

Dr. Farrington, “Glioblastoma tedavisindeki zorluk, \u00e7ok fazla h\u00fccresel mutasyon ve \u00e7ok fazla yol olmas\u0131d\u0131r” diyor. <\/span>“Bir yolu deneyebilir ve baz\u0131 h\u00fccreleri \u00f6ld\u00fcrebilirsiniz, ancak sonra onu yenmenin bir yolunu bulurlar. Kanser zekidir. Kanser, v\u00fccudunuzda \u00e7\u0131ld\u0131rm\u0131\u015f ve nas\u0131l b\u00fcy\u00fcy\u00fcp b\u00fcy\u00fcyece\u011fini \u00f6\u011frenmi\u015f h\u00fccrelerdir.” <\/span>Ancak daha fazla mutasyon, geli\u015fmi\u015f genomik testlerden elde edilen bilgilerle glioblastomalar\u0131 hedeflemek i\u00e7in daha fazla f\u0131rsat anlam\u0131na da gelir. <\/span>Testler, t\u00fcm\u00f6rleri molek\u00fcler d\u00fczeyde incelemek ve daha spesifik tedavilere yol a\u00e7abilecek spesifik mutasyonlar\u0131 belirlemek i\u00e7in kullan\u0131l\u0131r. <\/span>Dr. Farrington, “Di\u011fer bir\u00e7ok kanserde, sald\u0131r\u0131ya u\u011framayan genetik mutasyonlar\u0131m\u0131z var, en az\u0131ndan \u015fu anda de\u011fil,” diyor. <\/span>“Glioblastomda, sald\u0131rabilece\u011fimiz ve tedavi edebilece\u011fimiz \u00e7oklu mutasyonlar\u0131m\u0131z var. <\/span>Ancak bu t\u00fcm\u00f6rlerin \u00e7ok fazla mutasyonu var, bu y\u00fczden baz\u0131lar\u0131n\u0131 tedavi edebiliyoruz, ancak 12 tanesini ayn\u0131 anda tedavi etmek zor. <\/span>Tedaviyi b\u00f6yle yapan da budur. <\/span>Zor . <\/span>“<\/span><\/span><\/p>\n

Onkologlar ayr\u0131ca, kanserin sald\u0131rganl\u0131\u011f\u0131n\u0131n \u00f6ng\u00f6r\u00fclemeyen do\u011fas\u0131 nedeniyle glioblastomlu hastalar i\u00e7in uzun vadeli prognozu belirlemekte g\u00fc\u00e7l\u00fck \u00e7ekiyorlar. <\/span>Daha fazla ipucu aramak i\u00e7in Johns Hopkins Medicine ara\u015ft\u0131rmac\u0131lar\u0131, bir glioblastoma h\u00fccresinin ne kadar h\u0131zl\u0131 hareket etti\u011fini belirlemelerini sa\u011flayan h\u00fccresel bir “yar\u0131\u015f yolu” dedikleri \u015feyi geli\u015ftirdiler. <\/span>\u00d6n sonu\u00e7lar, h\u00fccre ne kadar h\u0131zl\u0131 olursa, t\u00fcm\u00f6r\u00fcn o kadar agresif oldu\u011funu g\u00f6sterir. <\/span>Johns Hopkins \u00dcniversitesi T\u0131p Fak\u00fcltesi’nden Dr. Alfredo Quinones-Hinojosa, bu testlerin bir g\u00fcn daha do\u011fru te\u015fhislere yol a\u00e7abilece\u011fini ve “yararl\u0131 g\u00fcncellemeler sa\u011flayabilece\u011fini, tedavi se\u00e7eneklerini bilgilendirebilece\u011fini ve muhtemelen yeni tedavileri daha h\u0131zl\u0131 geli\u015ftirebilece\u011fini” \u00f6ne s\u00fcr\u00fcyor.<\/span><\/span><\/p>\n

Daha iyi tedaviler ve \u00f6nleme stratejileri aray\u0131\u015f\u0131nda olan bilim adamlar\u0131, en zorlu ortamlarda bile kanserin nas\u0131l b\u00fcy\u00fcd\u00fc\u011f\u00fc ve hayatta kald\u0131\u011f\u0131 hakk\u0131nda daha fazla \u015fey \u00f6\u011freniyor. <\/span>Bu blog, Kanser Nas\u0131l Yapar? adl\u0131 ara s\u0131ra yay\u0131nlanan bir dizinin par\u00e7as\u0131d\u0131r. <\/span>B\u00fcy\u00fcyen anlay\u0131\u015f\u0131m\u0131za katk\u0131da bulunan, yak\u0131n zamanda ke\u015ffedilen kanserle ilgili davran\u0131\u015flar\u0131 vurgulamak i\u00e7in tasarlanm\u0131\u015ft\u0131r.<\/span><\/span><\/em><\/p>\n

Glioblastoma, semptomlar\u0131 ve onunla sava\u015fmak i\u00e7in kullan\u0131lan tedaviler hakk\u0131nda daha fazla bilgi edinin.<\/span><\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Glioblastomlar ba\u011f\u0131\u015f\u0131kl\u0131k sisteminden nas\u0131l kaybolur? T\u00fcm kanser h\u00fccreleri zararl\u0131d\u0131r, ancak \u00e7ok az\u0131 bir beyin kanseri t\u00fcr\u00fc olan glioblastomay\u0131 olu\u015fturanlar kadar agresif ve istilac\u0131 davran\u0131r. Yeni ara\u015ft\u0131rmalar \u015fimdi glioblastoma h\u00fccrelerinin v\u00fccudun ba\u011f\u0131\u015f\u0131kl\u0131k sisteminden nas\u0131l sakland\u0131\u011f\u0131na dair ipu\u00e7lar\u0131 sa\u011flayarak bilim adamlar\u0131na fikirlerin daha do\u011fru te\u015fhislere ve daha iyi tedavi se\u00e7eneklerine yol a\u00e7abilece\u011fini umuyor. T\u00fcm kanserler gibi, glioblastomlar …<\/p>\n","protected":false},"author":1,"featured_media":15075,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-15207","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-tr"],"yoast_head":"\nGlioblastomlar ba\u011f\u0131\u015f\u0131kl\u0131k sisteminden nas\u0131l kaybolur? - zdmaa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zdmaa.com\/tr\/how-do-glioblastomas-hide-from-the-immune-system\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Glioblastomlar ba\u011f\u0131\u015f\u0131kl\u0131k sisteminden nas\u0131l kaybolur? - zdmaa\" \/>\n<meta property=\"og:description\" content=\"Glioblastomlar ba\u011f\u0131\u015f\u0131kl\u0131k sisteminden nas\u0131l kaybolur? T\u00fcm kanser h\u00fccreleri zararl\u0131d\u0131r, ancak \u00e7ok az\u0131 bir beyin kanseri t\u00fcr\u00fc olan glioblastomay\u0131 olu\u015fturanlar kadar agresif ve istilac\u0131 davran\u0131r. Yeni ara\u015ft\u0131rmalar \u015fimdi glioblastoma h\u00fccrelerinin v\u00fccudun ba\u011f\u0131\u015f\u0131kl\u0131k sisteminden nas\u0131l sakland\u0131\u011f\u0131na dair ipu\u00e7lar\u0131 sa\u011flayarak bilim adamlar\u0131na fikirlerin daha do\u011fru te\u015fhislere ve daha iyi tedavi se\u00e7eneklerine yol a\u00e7abilece\u011fini umuyor. 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T\u00fcm kanser h\u00fccreleri zararl\u0131d\u0131r, ancak \u00e7ok az\u0131 bir beyin kanseri t\u00fcr\u00fc olan glioblastomay\u0131 olu\u015fturanlar kadar agresif ve istilac\u0131 davran\u0131r. Yeni ara\u015ft\u0131rmalar \u015fimdi glioblastoma h\u00fccrelerinin v\u00fccudun ba\u011f\u0131\u015f\u0131kl\u0131k sisteminden nas\u0131l sakland\u0131\u011f\u0131na dair ipu\u00e7lar\u0131 sa\u011flayarak bilim adamlar\u0131na fikirlerin daha do\u011fru te\u015fhislere ve daha iyi tedavi se\u00e7eneklerine yol a\u00e7abilece\u011fini umuyor. 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