{"id":15398,"date":"2022-01-03T15:44:02","date_gmt":"2022-01-03T12:44:02","guid":{"rendered":"https:\/\/zdmaa.com\/what-does-a-brca-gene-mutation-mean-for-men\/"},"modified":"2022-01-03T23:43:41","modified_gmt":"2022-01-03T20:43:41","slug":"what-does-a-brca-gene-mutation-mean-for-men","status":"publish","type":"post","link":"https:\/\/zdmaa.com\/tr\/what-does-a-brca-gene-mutation-mean-for-men\/","title":{"rendered":"BRCA gen mutasyonu erkekler i\u00e7in ne anlama geliyor?"},"content":{"rendered":"

BRCA gen mutasyonu erkekler i\u00e7in ne anlama geliyor?<\/span><\/span><\/span><\/span><\/p>\n

\n

Bu g\u00fcnlerde meme kanserinin t\u00fcm fark\u0131ndal\u0131\u011f\u0131yla birlikte, BRCA gen mutasyonlar\u0131n\u0131n olu\u015fturdu\u011fu risklere \u00e7ok dikkat edildi. <\/span>Ancak erkeklerin BRCA mutasyonuna sahip olma olas\u0131l\u0131\u011f\u0131 kad\u0131nlar kadar y\u00fcksek olsa da, bir\u00e7ok insan yanl\u0131\u015fl\u0131kla BRCA’n\u0131n yaln\u0131zca kad\u0131nlar i\u00e7in bir endi\u015fe kayna\u011f\u0131 oldu\u011funa inan\u0131yor. <\/span>Philadelphia’daki Hastanemizde genetik dan\u0131\u015fman\u0131 olan Melanie Korpman, “Erkekler bir BRCA mutasyonundan kanser geli\u015ftirme riski kad\u0131nlara g\u00f6re \u00e7ok daha d\u00fc\u015f\u00fck oldu\u011fundan, mutasyon i\u00e7in test edilme olas\u0131l\u0131klar\u0131 daha d\u00fc\u015f\u00fck” diyor. <\/span>“Erkekler bir BRCA mutasyonuna sahip olabilir, ancak bunu asla bilmezler.” <\/span>Bu genetik fakt\u00f6r\u00fc bilmek iki nedenden dolay\u0131 \u00f6nemlidir: Erkeklerin \u00e7ocuklar\u0131na mutasyon ta\u015f\u0131mas\u0131 muhtemel olmakla kalmaz, ayn\u0131 zamanda BRCA mutasyonlar\u0131 da erkeklerde baz\u0131 kanserlerin daha y\u00fcksek insidans\u0131 ile ba\u011flant\u0131l\u0131d\u0131r.<\/span><\/span><\/p>\n

Babalar, de\u011fi\u015ftirilmi\u015f BRCA genini annelerle ayn\u0131 oranda iletir. <\/span>Bir ebeveyn mutasyona u\u011fram\u0131\u015f geni ta\u015f\u0131d\u0131\u011f\u0131nda, onu o\u011fluna veya k\u0131z\u0131na ge\u00e7irme \u015fans\u0131 y\u00fczde 50’dir. <\/span>Korpman, “Test yapt\u0131rma karar\u0131 baz\u0131 erkekler i\u00e7in \u00e7ok zor olabilir” diyor. <\/span>“\u00c7ocuklar\u0131na aktarabileceklerini \u00f6\u011frenmeleri zor.”<\/span><\/span><\/p>\n

BRCA pozitifli\u011fi ne anlama geliyor?<\/span><\/span><\/h2>\n

BRCA pozitif olmak kanser tan\u0131s\u0131 almakla ayn\u0131 \u015fey de\u011fildir, ancak \u00f6zellikle kad\u0131nlarda hastal\u0131\u011fa yakalanma riskini \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131r\u0131r. <\/span>Artan riskle ilgili endi\u015feler, aktris Angelina Jolie’nin mutasyon i\u00e7in test edilmesine neden oldu ve pozitif test etti\u011finde \u00f6nlem olarak g\u00f6\u011f\u00fcslerini ve yumurtal\u0131klar\u0131n\u0131 ald\u0131rmaya karar verdi.<\/span><\/span><\/p>\n

Jolie’nin eylemleri, kal\u0131tsal kanserler i\u00e7in yap\u0131lan genetik testlere \u0131\u015f\u0131k tuttu, ancak mutasyonlar\u0131n erkekleri nas\u0131l etkiledi\u011fine dair tart\u0131\u015fmalar da s\u0131n\u0131rl\u0131 kald\u0131. <\/span>T\u00fcm meme kanserlerinin yaln\u0131zca y\u00fczde 1’i erkeklerde g\u00f6r\u00fclmesine ra\u011fmen, bir BRCA meme kanseri mutasyonu, \u00f6zellikle BRCA2 meme kanseri olan erkeklerde hastal\u0131k riskini art\u0131r\u0131r. <\/span>BRCA pozitif olmak, bir erke\u011fin pankreas kanseri, melanom ve daha agresif bir prostat kanseri t\u00fcr\u00fc geli\u015ftirme olas\u0131l\u0131\u011f\u0131n\u0131 da art\u0131r\u0131r.<\/span><\/span><\/p>\n

2016 New England Journal of Medicine<\/span><\/span><\/em> \u00e7al\u0131\u015fmas\u0131nda <\/span>, metastatik prostat kanserli erkeklerin yakla\u015f\u0131k y\u00fczde 12’si, yakla\u015f\u0131k sekizde biri bir BRCA mutasyonu ta\u015f\u0131yor <\/span>. <\/span>Bu, BRCA mutasyonu ta\u015f\u0131yan meme kanserli kad\u0131nlar\u0131n y\u00fczdesinden daha y\u00fcksek bir orand\u0131r.<\/span><\/span><\/p>\n

BRCA meme kanseri mutasyonuna sahip olmak, erkekler i\u00e7in test ve tedavi i\u00e7in ek \u00e7\u0131kar\u0131mlara sahiptir. <\/span>\u00d6ncelikle prostat ve meme kanseri orta risk fakt\u00f6rlerine sahip erkeklere g\u00f6re daha erken ya\u015fta taranmal\u0131d\u0131r. <\/span>Ulusal Kapsaml\u0131 Kanser A\u011f\u0131 (NCCN), BRCA mutasyonu olan erkeklerin y\u0131ll\u0131k meme muayenelerine ve klinik meme muayenelerine 35 ya\u015f\u0131nda ba\u015flamalar\u0131n\u0131 tavsiye eder. NCCN ayr\u0131ca 40 ya\u015f ve \u00fczeri BRCA mutasyon ta\u015f\u0131y\u0131c\u0131lar\u0131 i\u00e7in prostat kanseri taramas\u0131 yap\u0131lmas\u0131n\u0131 \u00f6nerir.<\/span><\/span><\/p>\n

Atlanta yak\u0131nlar\u0131ndaki hastanemizde genetik dan\u0131\u015fman\u0131 olan Altovise Ewing, \u201c\u00d6zellikle ailesinde prostat kanseri \u00f6yk\u00fcs\u00fc varsa, 30’lu ya\u015flar\u0131nda prostat kanseri taramas\u0131 yap\u0131lma \u015fans\u0131 var\u201d diyor. <\/span>“Bu ki\u015finin ailesinde prostat kanserinin ilk ortaya \u00e7\u0131kt\u0131\u011f\u0131 ya\u015ftan 10 y\u0131l \u00f6nce taramaya ba\u015flamas\u0131 uygun olur.”<\/span><\/span><\/p>\n

BRCA Wallridge<\/span><\/span><\/span><\/span><\/h2>\n

Erkekler, kanser risklerini tart\u0131\u015fmak ve a\u015fa\u011f\u0131daki durumlarda BRCA ve di\u011fer genetik testler i\u00e7in aday olup olmad\u0131klar\u0131n\u0131 belirlemek i\u00e7in bir genetik dan\u0131\u015fman veya ba\u015fka bir t\u0131p uzman\u0131yla g\u00f6r\u00fc\u015fmeyi d\u00fc\u015f\u00fcnmelidir:<\/span><\/span><\/p>\n

    \n
  • Ki\u015fisel veya aile ge\u00e7mi\u015finizde erkek meme kanseri var.<\/span><\/span><\/li>\n
  • Agresif prostat kanseri olan en az iki erke\u011fin ki\u015fisel veya aile \u00f6yk\u00fcs\u00fcne sahip olmak (Gleason skoru 7 veya daha y\u00fcksek)<\/span><\/span><\/li>\n
  • Ki\u015fisel veya aile ge\u00e7mi\u015finizde pankreas kanseri ve bir veya daha fazla meme, yumurtal\u0131k ve pankreas kanseri ge\u00e7mi\u015finiz var.<\/span><\/span><\/li>\n
  • Ailenizde yumurtal\u0131k kanseri \u00f6yk\u00fcs\u00fc var. <\/span>Erken ya\u015fta (50 ya\u015f\u0131ndan \u00f6nce) meme kanseri ge\u00e7irmi\u015f veya birden fazla primer meme kanseri ge\u00e7irmi\u015f akrabalar; <\/span>Her ya\u015fta meme kanseri te\u015fhisi konmu\u015f \u00fc\u00e7 veya daha fazla kad\u0131n akraba<\/span><\/span><\/li>\n
  • Ailenizde meme, yumurtal\u0131k, pankreas, prostat veya cilt kanseri \u00f6yk\u00fcs\u00fc var.<\/span><\/span><\/li>\n
  • A\u015fkenaz Yahudi k\u00f6kenlidirler ve ki\u015fisel bir meme, yumurtal\u0131k, pankreas, agresif prostat veya cilt kanseri ge\u00e7mi\u015fine sahiptirler.<\/span><\/span><\/li>\n
  • BRCA1 veya BRCA2 mutasyonunun bilinen bir aile ge\u00e7mi\u015finiz var<\/span><\/span><\/li>\n<\/ul>\n

    Bir genetik dan\u0131\u015fmanla g\u00f6r\u00fc\u015f\u00fcrseniz, genetik testin iyi bir se\u00e7enek olup olmayaca\u011f\u0131n\u0131 belirlemek i\u00e7in ilk g\u00f6r\u00fc\u015fmede ki\u015fisel ve aile t\u0131bbi ge\u00e7mi\u015finizi toplayacakt\u0131r. <\/span>Genetik testler genellikle tavsiye edilirse kan veya t\u00fck\u00fcr\u00fck testi ile yap\u0131l\u0131r. <\/span>Ewing, “Genetik test, insanlar i\u00e7in bir se\u00e7enektir” diyor. <\/span>“Genetik dan\u0131\u015fmanlar olarak, insanlar\u0131n kendileri i\u00e7in en iyi kararlar\u0131 verdi\u011fine inan\u0131yoruz ve bu karar vermeyi kolayla\u015ft\u0131rmaya yard\u0131mc\u0131 olmak bizim g\u00f6revimiz.”<\/span><\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

    BRCA gen mutasyonu erkekler i\u00e7in ne anlama geliyor? Bu g\u00fcnlerde meme kanserinin t\u00fcm fark\u0131ndal\u0131\u011f\u0131yla birlikte, BRCA gen mutasyonlar\u0131n\u0131n olu\u015fturdu\u011fu risklere \u00e7ok dikkat edildi. Ancak erkeklerin BRCA mutasyonuna sahip olma olas\u0131l\u0131\u011f\u0131 kad\u0131nlar kadar y\u00fcksek olsa da, bir\u00e7ok insan yanl\u0131\u015fl\u0131kla BRCA’n\u0131n yaln\u0131zca kad\u0131nlar i\u00e7in bir endi\u015fe kayna\u011f\u0131 oldu\u011funa inan\u0131yor. Philadelphia’daki Hastanemizde genetik dan\u0131\u015fman\u0131 olan Melanie Korpman, “Erkekler …<\/p>\n","protected":false},"author":1,"featured_media":14981,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-15398","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-tr"],"yoast_head":"\nBRCA gen mutasyonu erkekler i\u00e7in ne anlama geliyor? - zdmaa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zdmaa.com\/tr\/what-does-a-brca-gene-mutation-mean-for-men\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"BRCA gen mutasyonu erkekler i\u00e7in ne anlama geliyor? - zdmaa\" \/>\n<meta property=\"og:description\" content=\"BRCA gen mutasyonu erkekler i\u00e7in ne anlama geliyor? Bu g\u00fcnlerde meme kanserinin t\u00fcm fark\u0131ndal\u0131\u011f\u0131yla birlikte, BRCA gen mutasyonlar\u0131n\u0131n olu\u015fturdu\u011fu risklere \u00e7ok dikkat edildi. Ancak erkeklerin BRCA mutasyonuna sahip olma olas\u0131l\u0131\u011f\u0131 kad\u0131nlar kadar y\u00fcksek olsa da, bir\u00e7ok insan yanl\u0131\u015fl\u0131kla BRCA’n\u0131n yaln\u0131zca kad\u0131nlar i\u00e7in bir endi\u015fe kayna\u011f\u0131 oldu\u011funa inan\u0131yor. 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Bu g\u00fcnlerde meme kanserinin t\u00fcm fark\u0131ndal\u0131\u011f\u0131yla birlikte, BRCA gen mutasyonlar\u0131n\u0131n olu\u015fturdu\u011fu risklere \u00e7ok dikkat edildi. Ancak erkeklerin BRCA mutasyonuna sahip olma olas\u0131l\u0131\u011f\u0131 kad\u0131nlar kadar y\u00fcksek olsa da, bir\u00e7ok insan yanl\u0131\u015fl\u0131kla BRCA’n\u0131n yaln\u0131zca kad\u0131nlar i\u00e7in bir endi\u015fe kayna\u011f\u0131 oldu\u011funa inan\u0131yor. 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