{"id":15476,"date":"2022-01-03T15:25:23","date_gmt":"2022-01-03T12:25:23","guid":{"rendered":"https:\/\/zdmaa.com\/attacking-cancer-with-combinations-of-drugs-therapies\/"},"modified":"2022-01-04T00:32:12","modified_gmt":"2022-01-03T21:32:12","slug":"attacking-cancer-with-combinations-of-drugs-therapies","status":"publish","type":"post","link":"https:\/\/zdmaa.com\/tr\/attacking-cancer-with-combinations-of-drugs-therapies\/","title":{"rendered":"\u00c7e\u015fitli ila\u00e7lar ve tedavilerle kansere sald\u0131rmak"},"content":{"rendered":"

\u00c7e\u015fitli ila\u00e7lar ve tedavilerle kansere sald\u0131rmak<\/span><\/span><\/span><\/span><\/p>\n

\n

Kanser h\u00fccreleri b\u00fcy\u00fck \u00f6l\u00e7\u00fcde \u00e7evrelerine uyum sa\u011flama yetenekleri nedeniyle hayatta kal\u0131r ve buna baz\u0131 kanser tedavilerinden gelen bir sald\u0131r\u0131y\u0131 savu\u015fturmak da dahildir. <\/span>Bir ila\u00e7 kanser h\u00fccresindeki bir genetik mutasyonu hedefleyebilir, ancak ba\u015fka bir mutasyon t\u00fcm\u00f6r b\u00fcy\u00fcmesini kontrol edebilir ve b\u00fcy\u00fcmesine neden olabilir. <\/span>Ba\u015fka bir ila\u00e7, kanser h\u00fccrelerinin b\u00fcy\u00fcmesine izin veren sinyal yolunu kapatabilir, ancak bir t\u00fcm\u00f6r ileti\u015fim kurmak ve hayatta kalmak i\u00e7in yeni bir yol bulabilir. <\/span>Kanser tedavilere uyum sa\u011flad\u0131k\u00e7a ilaca diren\u00e7 ve\/veya n\u00fcksetme meydana gelebilir.<\/span><\/span><\/p>\n

Klinisyenlerin ve ara\u015ft\u0131rmac\u0131lar\u0131n bu t\u00fcr relapslar\u0131 ve direnci ortaya \u00e7\u0131kmadan \u00f6nlemeye \u00e7al\u0131\u015ft\u0131klar\u0131 bir yol, kanser h\u00fccrelerine birden fazla d\u00fczeyde sald\u0131rmak i\u00e7in tasarlanm\u0131\u015f kombinasyon ila\u00e7 tedavilerini kullanmakt\u0131r. <\/span>\u00d6rne\u011fin, Amerikan G\u0131da ve \u0130la\u00e7 \u0130daresi onayl\u0131 \u00fczerine ABD (FDA) kullan\u0131m ait <\/span>Temmuz ay\u0131nda iki hedefe y\u00f6nelik: \u0130la\u00e7 Neratinib (Nerlynx <\/span><\/span>\u00ae<\/span><\/span><\/sup> ) ve trastuzumab (Herceptin <\/span><\/span>\u00ae<\/span><\/span><\/sup><\/p>\n

Yeni gruplar ar\u0131yorum<\/span><\/span><\/h2>\n

Hedefe y\u00f6nelik tedavi ve imm\u00fcnoterapi ila\u00e7lar\u0131 gibi kesin kanser tedavilerinin ke\u015ffi, ke\u015ffedilecek d\u00fczinelerce yeni form\u00fclasyon sa\u011flar. <\/span>Geli\u015fmi\u015f Bireysel T\u0131p Merkezi t\u0131bbi direkt\u00f6r\u00fc ve Philadelphia’daki Hastanemizde hematolog, onkolog ve t\u0131bbi onkolog olan Ankur Parikh, “Kontrol noktas\u0131 inhibit\u00f6rleri olarak adland\u0131r\u0131lan imm\u00fcnoterapi ila\u00e7lar\u0131 genellikle kendi ba\u015flar\u0131na kullan\u0131l\u0131r” diyor. <\/span>“Ama \u015fimdi, bu umut verici verilerle kombinasyon tedavisi ara\u015ft\u0131r\u0131l\u0131yor. Melanom ile ili\u015fkili beyin metastazlar\u0131 olan hastalarda anti-PD-1 tedavisi ile birlikte radyasyon kullanan veriler yay\u0131nland\u0131. Akci\u011fer kanserlerinde radyoterapi ile birlikte kontrol noktas\u0131 inhibit\u00f6rleri de ara\u015ft\u0131r\u0131l\u0131yor. ara\u015ft\u0131r\u0131ld\u0131.” <\/span>Asl\u0131nda, G\u0131da ve \u0130la\u00e7 Dairesi , <\/span>ABD’yi ve Bembroleezzomab noktalar\u0131n\u0131 (Keytruda <\/span>\u00ae)<\/span><\/sup> inhibit\u00f6r incelemesini onaylad\u0131.<\/span><\/span>) belirli bir tip metastatik k\u00fc\u00e7\u00fck h\u00fccreli d\u0131\u015f\u0131 akci\u011fer kanseri olan hastalarda birinci basamak tedavi olarak pemetrexed ve karboplatin kemoterapi ila\u00e7lar\u0131 ile kombinasyon halinde.<\/span><\/span><\/p>\n

Doktorlar, birka\u00e7 y\u0131ld\u0131r hedefe y\u00f6nelik tedavi ve imm\u00fcnoterapi ila\u00e7lar\u0131n\u0131 i\u00e7eren ila\u00e7 ve tedavilerin bir kombinasyonunu kullan\u0131yorlar. <\/span>\u00d6rne\u011fin 2009 y\u0131l\u0131nda , <\/span>b\u00f6brek kanseri tedavisi i\u00e7in sitokinler olarak bilinen imm\u00fcnoterapi olan interferon-alfa ile kombinasyon halinde <\/span>ila\u00e7 tedavisine y\u00f6nelik bevacizumab (Avastin <\/span><\/span>\u00ae<\/span><\/span><\/sup> ) <\/span>konusunda G\u0131da ve \u0130la\u00e7 \u0130daresi taraf\u0131ndan <\/span>onaylanm\u0131\u015ft\u0131r <\/span>. <\/span>2015 y\u0131l\u0131nda , <\/span>metastatik melanomlu baz\u0131 hastalar\u0131 tedavi etmek i\u00e7in <\/span>muayene nivolumab inhibit\u00f6r noktalar\u0131n\u0131n (Opdivo <\/span><\/span>\u00ae<\/span><\/span><\/sup> ) ve Ipilimumab’\u0131n (Yervoy <\/span><\/span>\u00ae<\/span><\/span><\/sup> ) <\/span>bile\u015fimi hakk\u0131nda G\u0131da ve \u0130la\u00e7 Dairesi (FDA) taraf\u0131ndan <\/span>onaylanm\u0131\u015ft\u0131r <\/span>.<\/span><\/span><\/p>\n

Teorik olarak, bu gruplar farkl\u0131 resept\u00f6rlere, enzimlere veya yolaklara sald\u0131rarak kanser h\u00fccrelerinin ba\u011f\u0131\u015f\u0131kl\u0131k sisteminden ka\u00e7ma veya tedaviye direnme yeteneklerini bloke eder. <\/span>\u00d6rne\u011fin, kontrol noktas\u0131 inhibit\u00f6rleri, kanser h\u00fccrelerinin ba\u011f\u0131\u015f\u0131kl\u0131k sisteminden saklanmas\u0131na izin veren sinyalleri g\u00f6ndermek i\u00e7in kullan\u0131lan resept\u00f6rleri bloke etmek i\u00e7in tasarlanm\u0131\u015f imm\u00fcnoterapi ila\u00e7lar\u0131d\u0131r. <\/span>Ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccreleri, iyi, sa\u011fl\u0131kl\u0131 h\u00fccreler olup olmad\u0131klar\u0131n\u0131 veya enfeksiyon gibi bir tehdit olu\u015fturup olu\u015fturmad\u0131klar\u0131n\u0131 belirlemek i\u00e7in belirli kontrol noktalar\u0131nda di\u011fer h\u00fccreleri kontrol eder. <\/span>Bu kontrol noktalar\u0131 olmazsa, ba\u011f\u0131\u015f\u0131kl\u0131k sistemi sa\u011fl\u0131kl\u0131 h\u00fccrelere sald\u0131rabilir. <\/span>Nivolumab, PD-1 adl\u0131 bir kontrol noktas\u0131 resept\u00f6r\u00fcn\u00fc hedefler; <\/span>ipilimumab, CTLA-4 resept\u00f6r\u00fcn\u00fc hedefler. <\/span>\u0130ki ila\u00e7 tek ba\u015f\u0131na kullan\u0131ld\u0131\u011f\u0131nda baz\u0131 hastalarda i\u015fe yarad\u0131, ancak baz\u0131 melanom hastalar\u0131, ila\u00e7lar her iki resept\u00f6r\u00fc hedef alacak \u015fekilde birle\u015ftirildi\u011finde daha iyi sonu\u00e7 verdi. <\/span>Kontrol noktas\u0131 inhibit\u00f6rlerini di\u011fer ila\u00e7larla birle\u015ftirmek, kansere sald\u0131rma ve \u00f6ld\u00fcrme yeteneklerini de geli\u015ftirebilir.<\/span><\/span><\/p>\n

Tedaviler ve zamanlar<\/span><\/span><\/h2>\n

Ara\u015ft\u0131rmac\u0131lar i\u00e7in zorluk, do\u011fru ila\u00e7, tedavi ve s\u00fcre kombinasyonlar\u0131n\u0131 bulmakt\u0131r. <\/span>Hangi ila\u00e7lar veya tedaviler birlikte iyi sonu\u00e7 verir? <\/span>Birlikte mi yoksa ayr\u0131 ayr\u0131 m\u0131 verilmeli? <\/span>Hangi ila\u00e7 veya tedavi ilk \u00f6nce ve ne kadar s\u00fcreyle verilmelidir? <\/span>Cevaplar, kanser ila\u00e7lar\u0131 ve tedavilerinin kombinasyonlar\u0131n\u0131 ara\u015ft\u0131ran d\u00fczinelerce klinik deneyde ke\u015ffedilebilir. <\/span>Dr. Barrick’e g\u00f6re di\u011fer bir zorluk, ila\u00e7lar\u0131n hastan\u0131n genel sa\u011fl\u0131\u011f\u0131n\u0131 ve ya\u015fam kalitesini nas\u0131l etkiledi\u011fidir. <\/span>“Tedaviler birle\u015ftirildi\u011finde yan etkiler s\u0131kl\u0131kla birle\u015ftirilir. \u0130mm\u00fcnoterapinin di\u011fer tedavilerin yan etkileri \u00fczerindeki etkisini de bilmiyoruz.” <\/span>Baz\u0131 hastalarda imm\u00fcnoterapi ila\u00e7lar\u0131 ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin sa\u011fl\u0131kl\u0131 h\u00fccrelere sald\u0131rmas\u0131na neden olarak otoimm\u00fcn hastal\u0131k, grip benzeri semptomlar ve hatta \u00f6l\u00fcm gibi ciddi yan etkilere neden olabilir.<\/span><\/span><\/p>\n

Asl\u0131nda, Temmuz ay\u0131nda, G\u0131da ve \u0130la\u00e7 Dairesi, birka\u00e7 hasta \u00f6ld\u00fckten sonra multipl miyelomu tedavi etmek i\u00e7in pembrolizumab\u0131 di\u011fer ila\u00e7larla birle\u015ftiren iki \u00e7al\u0131\u015fmay\u0131 ask\u0131ya ald\u0131. <\/span>Bununla birlikte, ila\u00e7lar ve tedavi kombinasyonlar\u0131 \u00fczerine yap\u0131lan \u00e7al\u0131\u015fmalar \u00e7ok umut vericidir ve ara\u015ft\u0131rmac\u0131lar kanser hastalar\u0131 i\u00e7in daha iyi sonu\u00e7lar aramak i\u00e7in yeni ila\u00e7 kombinasyonlar\u0131n\u0131 ke\u015ffetmeye devam etmektedir. <\/span><\/span>Clinical and Translational Science<\/span><\/span><\/em> dergisindeki bir makale <\/span>, “kombine terapilerin kanser hastalar\u0131n\u0131n sonu\u00e7lar\u0131n\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde iyile\u015ftirebilece\u011fini ve bu t\u00fcr tedavilerin eninde sonunda kanser tedavisi i\u00e7in standart bak\u0131m haline gelmesinin beklendi\u011fini” \u00f6ne s\u00fcrd\u00fc\u011f\u00fcnde bir\u00e7ok ara\u015ft\u0131rmac\u0131n\u0131n ruh halini ele ge\u00e7irdi.<\/span><\/span><\/p>\n

Kanser tedavilerinin geli\u015ftirilmesinin nas\u0131l daha do\u011fru \u00e7\u00f6z\u00fcmler sa\u011flayabilece\u011fini \u00f6\u011frenin.<\/span><\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u00c7e\u015fitli ila\u00e7lar ve tedavilerle kansere sald\u0131rmak Kanser h\u00fccreleri b\u00fcy\u00fck \u00f6l\u00e7\u00fcde \u00e7evrelerine uyum sa\u011flama yetenekleri nedeniyle hayatta kal\u0131r ve buna baz\u0131 kanser tedavilerinden gelen bir sald\u0131r\u0131y\u0131 savu\u015fturmak da dahildir. Bir ila\u00e7 kanser h\u00fccresindeki bir genetik mutasyonu hedefleyebilir, ancak ba\u015fka bir mutasyon t\u00fcm\u00f6r b\u00fcy\u00fcmesini kontrol edebilir ve b\u00fcy\u00fcmesine neden olabilir. Ba\u015fka bir ila\u00e7, kanser h\u00fccrelerinin b\u00fcy\u00fcmesine izin …<\/p>\n","protected":false},"author":1,"featured_media":14943,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-15476","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-tr"],"yoast_head":"\n\u00c7e\u015fitli ila\u00e7lar ve tedavilerle kansere sald\u0131rmak - zdmaa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zdmaa.com\/tr\/attacking-cancer-with-combinations-of-drugs-therapies\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c7e\u015fitli ila\u00e7lar ve tedavilerle kansere sald\u0131rmak - zdmaa\" \/>\n<meta property=\"og:description\" content=\"\u00c7e\u015fitli ila\u00e7lar ve tedavilerle kansere sald\u0131rmak Kanser h\u00fccreleri b\u00fcy\u00fck \u00f6l\u00e7\u00fcde \u00e7evrelerine uyum sa\u011flama yetenekleri nedeniyle hayatta kal\u0131r ve buna baz\u0131 kanser tedavilerinden gelen bir sald\u0131r\u0131y\u0131 savu\u015fturmak da dahildir. 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