{"id":15802,"date":"2022-01-03T02:16:58","date_gmt":"2022-01-02T23:16:58","guid":{"rendered":"https:\/\/zdmaa.com\/immunotherapy-takes-cancer-treatment-into-a-new-era\/"},"modified":"2022-01-04T12:53:40","modified_gmt":"2022-01-04T09:53:40","slug":"immunotherapy-takes-cancer-treatment-into-a-new-era","status":"publish","type":"post","link":"https:\/\/zdmaa.com\/tr\/immunotherapy-takes-cancer-treatment-into-a-new-era\/","title":{"rendered":"\u0130mm\u00fcnoterapi, kanser tedavisini yeni bir \u00e7a\u011fa ta\u015f\u0131yor"},"content":{"rendered":"

\u0130mm\u00fcnoterapi, kanser tedavisini yeni bir \u00e7a\u011fa ta\u015f\u0131yor<\/span><\/span><\/span><\/span><\/p>\n

\n

\u0130mm\u00fcnoterapinin tarihi onlarca y\u0131l \u00f6ncesine dayanmaktad\u0131r, ancak son y\u0131llarda bir dizi yeni ila\u00e7 ve terapi, baz\u0131 tedavi etiketlerinin kanser tedavisinde yeni bir \u00e7a\u011f ba\u015flatt\u0131\u011f\u0131n\u0131 g\u00f6rm\u00fc\u015ft\u00fcr. <\/span>The Hospital of Chicago’da hematolog\/onkolog olan Eugene Ahn, \u201c\u0130mm\u00fcnoterapi kanser tedavisi alan\u0131nda yeni de\u011fil\u201d diyor. <\/span>“Ancak son y\u0131llarda \u00e7ok fazla heyecan yaratan \u015fey, yeni bir imm\u00fcnoterapi ila\u00e7lar\u0131 s\u0131n\u0131f\u0131yla uzun vadeli olumlu sonu\u00e7lar elde edebilen metastatik melanom ve akci\u011fer kanserli hastalar\u0131n ba\u015far\u0131 \u00f6yk\u00fcleridir.”<\/span><\/span><\/p>\n

Eski Ba\u015fkan Jimmy Carter en belirgin \u00f6rneklerden biridir. <\/span>A\u011fustos 2015’te Carter, karaci\u011fere ve beyne yay\u0131lm\u0131\u015f metastatik melanom te\u015fhisi kondu\u011funu a\u00e7\u0131klad\u0131. <\/span>D\u00f6rt ay sonra, imm\u00fcnoterapi g\u00f6rd\u00fckten sonra Carter, son beyin taramas\u0131n\u0131n kanser belirtisi g\u00f6stermedi\u011fini a\u00e7\u0131klad\u0131.<\/span><\/span><\/p>\n

Phoenix Hastanesinde klinik ara\u015ft\u0131rma direkt\u00f6r\u00fc ve onkolog Dr. Glenn Weiss, “Ba\u015fkan Carter’\u0131n vakas\u0131 kesinlikle imm\u00fcnoterapi tart\u0131\u015fmas\u0131n\u0131 \u00f6n plana \u00e7\u0131kard\u0131” diyor. <\/span>“Hastalar dan\u0131\u015fma randevular\u0131na belli bir bilgi birikimiyle geliyor ve do\u011fru sorular\u0131 soruyorlar: \u0130mm\u00fcnoterapi aday\u0131 m\u0131y\u0131m? Kat\u0131labilece\u011fim bir imm\u00fcnoterapi klinik ara\u015ft\u0131rman\u0131z var m\u0131?”<\/span><\/span><\/p>\n

Kontrol noktas\u0131 inhibit\u00f6rleri \u00fczerinde yaygara<\/span><\/span><\/h2>\n

Bembroleezzomab (Keytruda <\/span><\/span>\u00ae<\/span><\/span><\/sup> ), metastatik cilt kanseri tedavisinde kullan\u0131lan eski Ba\u015fkan Jimmy Carter, nivolumab (Opdivo <\/span><\/span>\u00ae<\/span><\/span><\/sup> ) ve Ipilimumab (Yervoy <\/span><\/span>\u00ae<\/span><\/span><\/sup> ), ba\u011f\u0131\u015f\u0131kl\u0131k tedavisi konusundaki <\/span>heyecan\u0131 art\u0131ran <\/span>“kontrol noktas\u0131 inhibit\u00f6rleri” olarak adland\u0131r\u0131lan ila\u00e7lardan. <\/span>Ba\u011f\u0131\u015f\u0131kl\u0131k sistemini belirli kanser h\u00fccrelerini hedef almas\u0131 i\u00e7in uyarmak \u00fczere tasarlanan bu ila\u00e7lar, cilt kanseri, b\u00f6brek kanseri ve\/veya akci\u011fer kanserini tedavi etmek i\u00e7in onaylanm\u0131\u015ft\u0131r. <\/span>Di\u011fer \u00e7e\u015fitli kanserler \u00fczerinde denemeler devam etmektedir.<\/span><\/span><\/p>\n

Kontrol noktas\u0131 inhibit\u00f6rleri, ba\u011f\u0131\u015f\u0131kl\u0131k sistemindeki T h\u00fccrelerinin spesifik resept\u00f6rlerini yeniden ba\u011flayarak \u00e7al\u0131\u015f\u0131r. <\/span>Al\u0131c\u0131lar normalde, istilac\u0131lar\u0131 aramak i\u00e7in v\u00fccutta dola\u015f\u0131rken T h\u00fccrelerini yava\u015flatan veya h\u0131zland\u0131ran fren ve h\u0131zland\u0131r\u0131c\u0131 g\u00f6revi g\u00f6r\u00fcr. <\/span>\u015eu anda piyasada bulunan imm\u00fcnoterapi ila\u00e7lar\u0131, belirli bir resept\u00f6rden gelen sinyali kesmeyi ve frenlere bask\u0131 yapmas\u0131n\u0131 \u00f6nlemeyi ama\u00e7l\u0131yor. <\/span>Bu, T h\u00fccrelerinin kontrol noktalar\u0131ndan h\u0131zla ge\u00e7mesine ve kanser h\u00fccrelerine sald\u0131rmas\u0131na izin verir.<\/span><\/span><\/p>\n

Kontrol noktas\u0131 inhibit\u00f6r\u00fc imm\u00fcnoterapi ila\u00e7lar\u0131 t\u0131p ve bilim \u00e7evrelerini gelecek i\u00e7in umutland\u0131rsa da, hala geli\u015fmekte olan bu kanser tedavisi alan\u0131 hakk\u0131nda bir\u00e7ok soru i\u015fareti var. <\/span>Bu ve di\u011fer gizemleri \u00e7\u00f6zmeye yard\u0131mc\u0131 olmak i\u00e7in klinisyenler ve ara\u015ft\u0131rmac\u0131lar, klinik deneylerde teorileri ve varsay\u0131mlar\u0131 test ediyor. <\/span>“Klinik ara\u015ft\u0131rmalar, halihaz\u0131rda onaylanm\u0131\u015f ila\u00e7lar\u0131n sonu\u00e7lar\u0131n\u0131 iyile\u015ftirmek ve yaln\u0131zca imm\u00fcnoterapiye yan\u0131t vermeyecek, ayn\u0131 zamanda umar\u0131z uzun vadeli bir yan\u0131ta sahip olacak hastalar\u0131n y\u00fczdesini art\u0131rmak i\u00e7in bu tedavilerin en g\u00fcvenli dozlar\u0131n\u0131, programlar\u0131n\u0131, s\u00fcresini ve kombinasyonunu de\u011ferlendiriyor. haftalar veya aylar de\u011fil, y\u0131llar.\u201d diyor Dr. Weiss.<\/span><\/span><\/p>\n

Ufukta ne var<\/span><\/span><\/h2>\n

\u00d6rne\u011fin, bir dizi deneme, farkl\u0131 kanser t\u00fcrlerine sahip hastalarda imm\u00fcnoterapinin etkinli\u011fini ara\u015ft\u0131r\u0131rken, olumlu sonu\u00e7lar elde etmek i\u00e7in tedavilerin nas\u0131l birle\u015ftirilece\u011finin ana hatlar\u0131n\u0131 \u00e7iziyor. <\/span>Dr. Weiss, “\u015eu anda, fayda sa\u011flama olas\u0131l\u0131\u011f\u0131 en y\u00fcksek olan hastalar\u0131 se\u00e7mek i\u00e7in harika bir yolumuz yok, ancak bunun \u00fczerinde \u00e7al\u0131\u015fan ara\u015ft\u0131rmac\u0131lardan olu\u015fan ekipler var” diyor. <\/span>“\u015eu anda, bu ila\u00e7lar kemoterapi gibi di\u011fer sistemik tedaviler i\u00e7in de uygun adaylar olarak kabul edilebilecek ileri metastazl\u0131 hastalara verilmektedir.”<\/span><\/span><\/p>\n

Ocak ay\u0131nda Phoenix Hastanemiz, imm\u00fcnoterapi ilac\u0131 nivolumab\u0131n baz\u0131 kemoterapilerle birle\u015ftirilmesinin etkinli\u011fini test eden yeni bir klinik deney ba\u015flatt\u0131. <\/span>Belirli kolorektal ve pankreas kanseri t\u00fcrlerini tedavi eden ila\u00e7lar. <\/span>\u00c7al\u0131\u015fma, di\u011fer geli\u015fmi\u015f kanserlerde imm\u00fcnoterapi ve kemoterapi kombinasyonlar\u0131n\u0131n nas\u0131l \u00e7al\u0131\u015ft\u0131\u011f\u0131na bakacakt\u0131r. <\/span>Aral\u0131k 2014’te ba\u015flayan ba\u015fka bir klinik \u00e7al\u0131\u015fmada, Dr. Weiss ve di\u011fer ara\u015ft\u0131rmac\u0131lar\u0131, pembrolizumab\u0131n geleneksel kemoterapi ile birle\u015ftirilmesinin, ilerlemi\u015f k\u00fc\u00e7\u00fck h\u00fccreli akci\u011fer kanseri ve k\u00fc\u00e7\u00fck h\u00fccreli olmayan akci\u011fer kanseri olan baz\u0131 hastalarda tek ba\u015f\u0131na kemoterapiden daha iyi sonu\u00e7lar verdi\u011fini buldu. <\/span>O zamandan beri, \u00e7al\u0131\u015fma, grubun sarkomlu ve di\u011fer ileri kanserli hastalar\u0131 tedavi etmedeki performans\u0131 \u00fczerine ara\u015ft\u0131rmalar\u0131 i\u00e7erecek \u015fekilde geni\u015fledi.<\/span><\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u0130mm\u00fcnoterapi, kanser tedavisini yeni bir \u00e7a\u011fa ta\u015f\u0131yor \u0130mm\u00fcnoterapinin tarihi onlarca y\u0131l \u00f6ncesine dayanmaktad\u0131r, ancak son y\u0131llarda bir dizi yeni ila\u00e7 ve terapi, baz\u0131 tedavi etiketlerinin kanser tedavisinde yeni bir \u00e7a\u011f ba\u015flatt\u0131\u011f\u0131n\u0131 g\u00f6rm\u00fc\u015ft\u00fcr. The Hospital of Chicago’da hematolog\/onkolog olan Eugene Ahn, \u201c\u0130mm\u00fcnoterapi kanser tedavisi alan\u0131nda yeni de\u011fil\u201d diyor. “Ancak son y\u0131llarda \u00e7ok fazla heyecan yaratan \u015fey, …<\/p>\n","protected":false},"author":1,"featured_media":14773,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-15802","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-tr"],"yoast_head":"\n\u0130mm\u00fcnoterapi, kanser tedavisini yeni bir \u00e7a\u011fa ta\u015f\u0131yor - zdmaa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zdmaa.com\/tr\/immunotherapy-takes-cancer-treatment-into-a-new-era\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u0130mm\u00fcnoterapi, kanser tedavisini yeni bir \u00e7a\u011fa ta\u015f\u0131yor - zdmaa\" \/>\n<meta property=\"og:description\" content=\"\u0130mm\u00fcnoterapi, kanser tedavisini yeni bir \u00e7a\u011fa ta\u015f\u0131yor \u0130mm\u00fcnoterapinin tarihi onlarca y\u0131l \u00f6ncesine dayanmaktad\u0131r, ancak son y\u0131llarda bir dizi yeni ila\u00e7 ve terapi, baz\u0131 tedavi etiketlerinin kanser tedavisinde yeni bir \u00e7a\u011f ba\u015flatt\u0131\u011f\u0131n\u0131 g\u00f6rm\u00fc\u015ft\u00fcr. The Hospital of Chicago’da hematolog\/onkolog olan Eugene Ahn, \u201c\u0130mm\u00fcnoterapi kanser tedavisi alan\u0131nda yeni de\u011fil\u201d diyor. “Ancak son y\u0131llarda \u00e7ok fazla heyecan yaratan \u015fey, …\" \/>\n<meta property=\"og:url\" content=\"https:\/\/zdmaa.com\/tr\/immunotherapy-takes-cancer-treatment-into-a-new-era\/\" \/>\n<meta property=\"og:site_name\" content=\"zdmaa\" \/>\n<meta property=\"article:published_time\" content=\"2022-01-02T23:16:58+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-01-04T09:53:40+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/zdmaa.com\/wp-content\/uploads\/2022\/01\/blood-g6392d83f9_640.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"640\" \/>\n\t<meta property=\"og:image:height\" content=\"480\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Yazan:\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tahmini okuma s\u00fcresi\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 dakika\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/zdmaa.com\/tr\/immunotherapy-takes-cancer-treatment-into-a-new-era\/\",\"url\":\"https:\/\/zdmaa.com\/tr\/immunotherapy-takes-cancer-treatment-into-a-new-era\/\",\"name\":\"\u0130mm\u00fcnoterapi, kanser tedavisini yeni bir \u00e7a\u011fa ta\u015f\u0131yor - 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