{"id":16717,"date":"2022-01-05T20:30:40","date_gmt":"2022-01-05T17:30:40","guid":{"rendered":"https:\/\/zdmaa.com\/genetic-testing-may-identify-personalized-therapies\/"},"modified":"2022-01-05T21:16:22","modified_gmt":"2022-01-05T18:16:22","slug":"genetic-testing-may-identify-personalized-therapies","status":"publish","type":"post","link":"https:\/\/zdmaa.com\/tr\/genetic-testing-may-identify-personalized-therapies\/","title":{"rendered":"Genetik testler ki\u015fiselle\u015ftirilmi\u015f tedavileri tan\u0131mlayabilir"},"content":{"rendered":"

Genetik testler ki\u015fiselle\u015ftirilmi\u015f tedavileri tan\u0131mlayabilir<\/span><\/span><\/span><\/span><\/p>\n

\n

Bir ilac\u0131n neden bir hastada i\u015fe yaray\u0131p di\u011ferinde i\u015fe yaramad\u0131\u011f\u0131n\u0131 hi\u00e7 merak ettiniz mi? <\/span>Cevap farmakogenomikte yat\u0131yor olabilir. <\/span>Bu b\u00fcy\u00fcyen ki\u015fiselle\u015ftirilmi\u015f t\u0131p alan\u0131, bir ki\u015finin benzersiz genetik yap\u0131s\u0131n\u0131n ila\u00e7lara ve ila\u00e7lara tepkisini nas\u0131l etkiledi\u011fini inceler.<\/span><\/span><\/p>\n

Amerika Kanser Tedavi Merkezlerinde t\u0131p ve bilim \u015fefi Murray Markman, \u201cGenlerimiz kan grubunu ve g\u00f6z rengini belirledi\u011fi gibi, v\u00fccudumuzun ila\u00e7lara nas\u0131l tepki verdi\u011finden k\u0131smen sorumludur\u201d diyor. <\/span><\/span>\u00ae<\/span><\/span><\/sup> (CTCA). <\/span>“Farmakogenomik, bir ilac\u0131n uygulanabilir bir tedavi olup olmayaca\u011f\u0131n\u0131 veya belirli yan etkilere neden olup olmayaca\u011f\u0131n\u0131 belirleyebilecek bu genlerdeki de\u011fi\u015fiklikleri arar.”<\/span><\/span><\/p>\n

Genetik fakt\u00f6rler ve farmakolojik tedaviler.<\/span><\/span><\/h2>\n

\u00c7al\u0131\u015fma alan\u0131, hastalar\u0131n kanser tedavileri de dahil olmak \u00fczere \u00e7e\u015fitli ila\u00e7lar\u0131 nas\u0131l i\u015fleyebilece\u011fini g\u00f6rmek i\u00e7in genotiplemeyi test ederek \u00e7al\u0131\u015f\u0131r. <\/span>Ki\u015filer aras\u0131ndaki farkl\u0131l\u0131klar, bir ilac\u0131n emilimini, metabolizmas\u0131n\u0131 veya aktivitesini etkileyebilir. <\/span>Dr. Markman, “Kanseri tedavi etmenin tek yolu h\u0131zla ge\u00e7mi\u015fte kalmakt\u0131r” diyor. <\/span>“Hastan\u0131n bireysel DNA’s\u0131n\u0131 do\u011frudan hedef alan ila\u00e7lar ve tedaviler ile de\u011fi\u015ftiriliyor.”<\/span><\/span><\/p>\n

\u015eu anda doktorlar re\u00e7etelerinin \u00e7o\u011funu kanserin evresi ve hastan\u0131n ya\u015f\u0131 ve cinsiyeti gibi klinik fakt\u00f6rlere dayand\u0131rmaktad\u0131r. <\/span>Ancak bir ki\u015finin geneti\u011fi, klinik fakt\u00f6rler kadar \u00f6nemli olabilir. <\/span>\u0130la\u00e7lar\u0131n k\u00fc\u00e7\u00fck bir alt grubu i\u00e7in ara\u015ft\u0131rmac\u0131lar, insanlar\u0131n tepki verme \u015feklini etkileyen genetik farkl\u0131l\u0131klar belirlediler. <\/span>Bu durumlarda, klinisyenler hangi ilac\u0131n i\u015fe yarama olas\u0131l\u0131\u011f\u0131n\u0131n daha y\u00fcksek oldu\u011funu se\u00e7mek ve al\u0131\u015f\u0131lmad\u0131k derecede y\u00fcksek veya d\u00fc\u015f\u00fck doza ihtiya\u00e7 duyan ki\u015fileri belirlemek i\u00e7in farmakogenomik bilgileri kullanabilir.<\/span><\/span><\/p>\n

Amerika Birle\u015fik Devletleri’ndeki t\u00fcm ila\u00e7lar\u0131n g\u00fcvenli\u011fini izleyen ABD G\u0131da ve \u0130la\u00e7 Dairesi, 150’den fazla ilac\u0131n etiketlerine ila\u00e7 genetik bilgisine yer verdi. <\/span>Belirli genetik farkl\u0131l\u0131klara sahip ki\u015filer i\u00e7in doz \u00f6nerilerini, olas\u0131 yan etkileri veya etkililik farkl\u0131l\u0131klar\u0131n\u0131 kapsayabilecek bu bilgiler, klinisyenlerin ila\u00e7 re\u00e7etelerini bireysel hastalara g\u00f6re uyarlamalar\u0131na yard\u0131mc\u0131 olabilir.<\/span><\/span><\/p>\n

Farmakogenomiklerin s\u0131n\u0131rlar\u0131<\/span><\/span><\/h2>\n

Ama s\u0131n\u0131rlamalar var. <\/span>Farmakogenomik, hastalar\u0131n t\u00fcm ila\u00e7lara nas\u0131l yan\u0131t verdi\u011fi hakk\u0131nda bilgi sa\u011flamaz. <\/span>Baz\u0131lar\u0131 birden fazla ila\u00e7 t\u00fcr\u00fc al\u0131yorsa birden fazla teste ihtiya\u00e7 duyabilir. <\/span>Dr. Markman, “Testler bir kristal k\u00fcre de\u011fildir. Durumunuz i\u00e7in ideal ilac\u0131 belirleyemez veya ila\u00e7 etkile\u015fimleri hakk\u0131nda bilgi sa\u011flayamaz” diyor. <\/span>“Alternatif olarak, farmakogenomik testler se\u00e7eneklerinizi daraltabilir ve klinisyenlerin do\u011fru ilac\u0131 daha h\u0131zl\u0131 re\u00e7ete etmelerine yard\u0131mc\u0131 olabilir.”<\/span><\/span><\/p>\n

Farmakogenomiklerin kullan\u0131m\u0131 s\u0131n\u0131rl\u0131 olmakla birlikte, klinik \u00e7al\u0131\u015fmalarda yeni yakla\u015f\u0131mlar \u00fczerinde \u00e7al\u0131\u015f\u0131lmaktad\u0131r. <\/span>Nihai hedef, farkl\u0131 kanser t\u00fcrleri de dahil olmak \u00fczere \u00e7ok \u00e7e\u015fitli sa\u011fl\u0131k sorunlar\u0131n\u0131 tedavi etmek i\u00e7in \u00f6zelle\u015ftirilmi\u015f ila\u00e7lar\u0131n geli\u015ftirilmesine yol a\u00e7acak testler geli\u015ftirmektir. <\/span>Dr. Markman, “Kanser tedavisinde hassas t\u0131p h\u0131zla geli\u015fiyor” diyor. <\/span>“Hassas t\u0131p giderek daha pop\u00fcler hale geldik\u00e7e, farmakogenomiklerin de daha standart hale gelmesi bekleniyor.”<\/span><\/span><\/p>\n

Kanserin kesin tedavisi hakk\u0131nda daha fazla bilgi edinin.<\/span><\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Genetik testler ki\u015fiselle\u015ftirilmi\u015f tedavileri tan\u0131mlayabilir Bir ilac\u0131n neden bir hastada i\u015fe yaray\u0131p di\u011ferinde i\u015fe yaramad\u0131\u011f\u0131n\u0131 hi\u00e7 merak ettiniz mi? Cevap farmakogenomikte yat\u0131yor olabilir. Bu b\u00fcy\u00fcyen ki\u015fiselle\u015ftirilmi\u015f t\u0131p alan\u0131, bir ki\u015finin benzersiz genetik yap\u0131s\u0131n\u0131n ila\u00e7lara ve ila\u00e7lara tepkisini nas\u0131l etkiledi\u011fini inceler. Amerika Kanser Tedavi Merkezlerinde t\u0131p ve bilim \u015fefi Murray Markman, \u201cGenlerimiz kan grubunu ve g\u00f6z …<\/p>\n","protected":false},"author":1,"featured_media":16701,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-16717","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-tr"],"yoast_head":"\nGenetik testler ki\u015fiselle\u015ftirilmi\u015f tedavileri tan\u0131mlayabilir - zdmaa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zdmaa.com\/tr\/genetic-testing-may-identify-personalized-therapies\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Genetik testler ki\u015fiselle\u015ftirilmi\u015f tedavileri tan\u0131mlayabilir - zdmaa\" \/>\n<meta property=\"og:description\" content=\"Genetik testler ki\u015fiselle\u015ftirilmi\u015f tedavileri tan\u0131mlayabilir Bir ilac\u0131n neden bir hastada i\u015fe yaray\u0131p di\u011ferinde i\u015fe yaramad\u0131\u011f\u0131n\u0131 hi\u00e7 merak ettiniz mi? 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