{"id":17292,"date":"2022-01-06T01:58:34","date_gmt":"2022-01-05T22:58:34","guid":{"rendered":"https:\/\/zdmaa.com\/fda-oks-first-cancer-treatment-based-on-genetic-makeup\/"},"modified":"2022-01-06T08:31:42","modified_gmt":"2022-01-06T05:31:42","slug":"fda-oks-first-cancer-treatment-based-on-genetic-makeup","status":"publish","type":"post","link":"https:\/\/zdmaa.com\/tr\/fda-oks-first-cancer-treatment-based-on-genetic-makeup\/","title":{"rendered":"ABD G\u0131da ve \u0130la\u00e7 Dairesi, ilk genetik yap\u0131 temelli kanser tedavisini onaylad\u0131"},"content":{"rendered":"

ABD G\u0131da ve \u0130la\u00e7 Dairesi, ilk genetik yap\u0131 temelli kanser tedavisini onaylad\u0131<\/span><\/span><\/span><\/span><\/p>\n

\n

Kanser geleneksel olarak v\u00fccudun neresinde geli\u015fti\u011fine g\u00f6re tan\u0131n\u0131r. <\/span>Meme kanseri memede olu\u015fur, akci\u011fer kanseri akci\u011ferlerde olu\u015fur vb. <\/span>Kanser v\u00fccudun farkl\u0131 bir b\u00f6lgesine yay\u0131ld\u0131\u011f\u0131nda bile, orijinal konumuna g\u00f6re belirlenir. <\/span>\u00d6rne\u011fin kolorektal kanser beyne yay\u0131l\u0131rsa buna beyin kanseri de\u011fil metastatik kolorektal kanser denir. <\/span>Ancak Philadelphia’daki Hastanemizde t\u0131bbi onkolog olan Shayma Master Kazmi, MD, RPh dahil olmak \u00fczere bir\u00e7ok doktor buna eski moda d\u00fc\u015f\u00fcnce diyor. <\/span>Dr. Kazmi, “Kanserleri ba\u015flad\u0131klar\u0131 yere g\u00f6re d\u00fc\u015f\u00fcn\u00fcrd\u00fck” diyor. <\/span>“Art\u0131k kanser hakk\u0131ndaki g\u00f6r\u00fc\u015flerimizi kendimizi bir ba\u015flang\u0131\u00e7 \u200b\u200bnoktas\u0131yla s\u0131n\u0131rlamak i\u00e7in de\u011fil, tasar\u0131m\u0131n\u0131, kanserin yay\u0131lma \u015feklini, b\u00fcy\u00fcme \u015feklini ve kanseri neyin i\u015fe yarad\u0131\u011f\u0131n\u0131 g\u00f6rmek i\u00e7in geni\u015fletiyoruz.”<\/span><\/span><\/p>\n

yenilik\u00e7i tedavi<\/span><\/span><\/h2>\n

ABD G\u0131da ve \u0130la\u00e7 Dairesi (FDA), bir t\u00fcm\u00f6r\u00fcn birincil b\u00f6lgesine de\u011fil, kanserin DNA’s\u0131nda bulunan belirli bir genetik \u00f6zelli\u011fe dayal\u0131 bir kanser tedavisini onaylama kritik ad\u0131m\u0131n\u0131 att\u0131\u011f\u0131 May\u0131s ay\u0131nda bu perspektifi destekledi. <\/span>Onay, bir <\/span>ila\u00e7 inhibit\u00f6r\u00fc incelemesine izin verir Bembroleezzomab noktas\u0131 (Keytruda <\/span><\/span>\u00ae<\/span><\/span><\/sup>) mikro uydu karars\u0131zl\u0131\u011f\u0131 (MSI-H) ve uyumsuzluk onar\u0131m eksikli\u011fi (dMMR) olarak adland\u0131r\u0131lan iki spesifik genetik \u00f6zellikten birine sahip, ameliyat edilemeyen metastatik t\u00fcm\u00f6rleri olan hastalar\u0131n tedavisinde kullan\u0131m i\u00e7indir. <\/span>Bu genetik mutasyonlar, bir h\u00fccrenin DNA’s\u0131n\u0131n kendini onarmas\u0131n\u0131 zorla\u015ft\u0131r\u0131r, bu da bir\u00e7ok t\u00fcm\u00f6r\u00fcn olu\u015fmas\u0131na ve b\u00fcy\u00fcmesine neden olan bir t\u00fcr kontrols\u00fcz h\u00fccre b\u00fcy\u00fcmesine yol a\u00e7abilir. <\/span>Karar, tarihinde ilk kez G\u0131da ve \u0130la\u00e7 \u0130daresi’nin genetik bir \u00f6zelli\u011fe dayal\u0131 bir kanser tedavisini onaylad\u0131\u011f\u0131na i\u015faret ediyor. <\/span>Amerika Kanser Tedavi Merkezleri t\u0131p ve bilim \u015fefi Murray Markman, “G\u0131da ve \u0130la\u00e7 Dairesi’nin (FDA) paradigmay\u0131 de\u011fi\u015ftiren bu kritik \u00f6neme sahip karar\u0131, gelecekteki kanser tedavilerinin nas\u0131l belirlenece\u011finin bir ba\u015fka \u00f6rne\u011fidir” diyor. <\/span><\/span>\u00ae<\/span><\/span><\/sup> (CTCA).<\/span><\/span><\/p>\n

Pembrolizumab gibi kontrol noktas\u0131 inhibit\u00f6rleri, baz\u0131 kanser h\u00fccreleri ile hastal\u0131klarla sava\u015fan T h\u00fccreleri aras\u0131nda yayg\u0131n olan ve kanserin ba\u011f\u0131\u015f\u0131kl\u0131k sisteminden gizlenmesine izin veren ileti\u015fimi bozmak i\u00e7in tasarlanm\u0131\u015f imm\u00fcnoterapi ila\u00e7lar\u0131d\u0131r. <\/span>Ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccreleri, enfeksiyon veya hastal\u0131k gibi n\u00f6tralize edilmesi gereken bir tehdit olu\u015fturup olu\u015fturmad\u0131klar\u0131n\u0131 belirlemek i\u00e7in belirli kontrol noktalar\u0131ndan ge\u00e7erken di\u011fer h\u00fccreleri kontrol etmeleri bak\u0131m\u0131ndan neredeyse v\u00fccudun polis g\u00fcc\u00fc gibidir. <\/span>Ancak kanser, i\u015flevsiz v\u00fccut h\u00fccrelerinden olu\u015ftu\u011fu i\u00e7in, baz\u0131 kanser h\u00fccreleri, kontrol noktalar\u0131ndan ge\u00e7erken ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccrelerinin y\u00fczeyinde bulunan protein resept\u00f6rlerine zor sinyaller g\u00f6ndererek tehditlerini maskeleyebilir. <\/span>Kontrol noktas\u0131 inhibit\u00f6rleri, bu resept\u00f6rleri bloke ederek ve kanseri zararl\u0131 ve sald\u0131rmaya haz\u0131r olarak ortaya \u00e7\u0131kararak \u00e7al\u0131\u015ft\u0131klar\u0131 i\u00e7in bu \u015fekilde adland\u0131r\u0131lm\u0131\u015ft\u0131r. <\/span>Bu kontrol noktalar\u0131 olmazsa, ba\u011f\u0131\u015f\u0131kl\u0131k sistemi sa\u011fl\u0131kl\u0131 h\u00fccrelere sald\u0131rabilir. <\/span>Kontrol noktas\u0131 inhibit\u00f6rlerinin amac\u0131, ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin kanser riskini tan\u0131mas\u0131na izin verirken sa\u011fl\u0131kl\u0131 h\u00fccreleri korumakt\u0131r. <\/span>Ancak her zaman tasarland\u0131\u011f\u0131 gibi \u00e7al\u0131\u015fm\u0131yor ve bilim adamlar\u0131 hala nedenini bulmaya \u00e7al\u0131\u015f\u0131yor.<\/span><\/span><\/p>\n

B\u00fcy\u00fck ilk ad\u0131m<\/span><\/span><\/h2>\n

Dr. Markman, “Bu ila\u00e7lar ba\u011f\u0131\u015f\u0131kl\u0131k sistemini frenler, b\u00f6ylece T h\u00fccrelerimiz yabanc\u0131 bir antijen arayabilirler” diyor. <\/span>“Soru \u015fu: Frenleri b\u0131rakt\u0131klar\u0131nda hangi kanser h\u00fccrelerini bulacaklar? Neye sald\u0131r\u0131yorlar?” <\/span>\u00d6rne\u011fin Pembrolizumab, kullan\u0131ld\u0131\u011f\u0131 s\u00fcrenin yakla\u015f\u0131k y\u00fczde 20’sinde olumlu sonu\u00e7lar verir. <\/span>Ara\u015ft\u0131rmac\u0131lar bunun neden baz\u0131 hastalarda i\u015fe yaray\u0131p di\u011ferlerinde i\u015fe yaramad\u0131\u011f\u0131n\u0131 bilmese de, MSI-H ve\/veya dMMR’deki kusurlar\u0131n, t\u00fcm\u00f6r\u00fcn nerede oldu\u011funa bak\u0131lmaks\u0131z\u0131n ilac\u0131n pozitif sonu\u00e7lar g\u00f6sterdi\u011fi kanserlerde bulundu\u011funu ke\u015ffettiler. <\/span>. <\/span>yer al\u0131r. <\/span>Asl\u0131nda bu kusurlar farkl\u0131 hastalarda, t\u00fcm kanser t\u00fcrlerinde bulunur. <\/span>MSI-H, t\u00fcm kolorektal adenomlar\u0131n y\u00fczde 15’inde ve ayr\u0131ca mesane, meme, prostat ve tiroid kanseri olan hastalarda tespit edilir.<\/span><\/span><\/p>\n

\u015eimdiye kadar, ABD G\u0131da ve \u0130la\u00e7 \u0130daresi, farkl\u0131 kanser t\u00fcrlerini tedavi etmek i\u00e7in kontrol noktas\u0131 inhibit\u00f6rlerini onaylad\u0131, ancak yaln\u0131zca akci\u011fer, mesane ve b\u00f6brekler gibi v\u00fccutta nerede olu\u015ftuklar\u0131na ba\u011fl\u0131 olarak. <\/span>\u0130la\u00e7lar ayr\u0131ca Hodgkin lenfoma ve metastatik melanomu tedavi etmek i\u00e7in onaylanm\u0131\u015ft\u0131r. <\/span>Dr. Kazemi, bu yeni onay\u0131 yaln\u0131zca kanserin spesifik genetik \u00f6zelli\u011fi \u00fczerinde benimseyerek, FDA’n\u0131n gelecekte kanserin nas\u0131l tedavi edilece\u011fini de\u011fi\u015ftirmede “b\u00fcy\u00fck ilk ad\u0131m\u0131” att\u0131\u011f\u0131n\u0131 s\u00f6yl\u00fcyor. <\/span>“FDA’n\u0131n geleneksel kanser tedavisi konusundaki g\u00f6r\u00fc\u015flerini de\u011fi\u015ftirmede bu kadar ilerici olmas\u0131 \u00e7ok heyecan verici” diyor. <\/span>“Kanserin k\u00f6keni taraf\u0131ndan k\u0131s\u0131tlanmak istemiyoruz. Ona \u00f6z\u00fcne, itici mekanizmas\u0131na sald\u0131rmak istiyoruz.”<\/span><\/span><\/p>\n

\u0130mm\u00fcnoterapinin neden baz\u0131 hastalar i\u00e7in etkili oldu\u011fu, ancak di\u011ferleri i\u00e7in etkili olmad\u0131\u011f\u0131 hakk\u0131nda daha fazla bilgi edinin.<\/span><\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

ABD G\u0131da ve \u0130la\u00e7 Dairesi, ilk genetik yap\u0131 temelli kanser tedavisini onaylad\u0131 Kanser geleneksel olarak v\u00fccudun neresinde geli\u015fti\u011fine g\u00f6re tan\u0131n\u0131r. Meme kanseri memede olu\u015fur, akci\u011fer kanseri akci\u011ferlerde olu\u015fur vb. Kanser v\u00fccudun farkl\u0131 bir b\u00f6lgesine yay\u0131ld\u0131\u011f\u0131nda bile, orijinal konumuna g\u00f6re belirlenir. \u00d6rne\u011fin kolorektal kanser beyne yay\u0131l\u0131rsa buna beyin kanseri de\u011fil metastatik kolorektal kanser denir. Ancak Philadelphia’daki …<\/p>\n","protected":false},"author":1,"featured_media":17276,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-17292","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-tr"],"yoast_head":"\nABD G\u0131da ve \u0130la\u00e7 Dairesi, ilk genetik yap\u0131 temelli kanser tedavisini onaylad\u0131 - zdmaa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zdmaa.com\/tr\/fda-oks-first-cancer-treatment-based-on-genetic-makeup\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ABD G\u0131da ve \u0130la\u00e7 Dairesi, ilk genetik yap\u0131 temelli kanser tedavisini onaylad\u0131 - zdmaa\" \/>\n<meta property=\"og:description\" content=\"ABD G\u0131da ve \u0130la\u00e7 Dairesi, ilk genetik yap\u0131 temelli kanser tedavisini onaylad\u0131 Kanser geleneksel olarak v\u00fccudun neresinde geli\u015fti\u011fine g\u00f6re tan\u0131n\u0131r. 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Meme kanseri memede olu\u015fur, akci\u011fer kanseri akci\u011ferlerde olu\u015fur vb. Kanser v\u00fccudun farkl\u0131 bir b\u00f6lgesine yay\u0131ld\u0131\u011f\u0131nda bile, orijinal konumuna g\u00f6re belirlenir. \u00d6rne\u011fin kolorektal kanser beyne yay\u0131l\u0131rsa buna beyin kanseri de\u011fil metastatik kolorektal kanser denir. 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