{"id":17628,"date":"2022-01-06T01:02:16","date_gmt":"2022-01-05T22:02:16","guid":{"rendered":"https:\/\/zdmaa.com\/study-bad-cell-copies-lead-to-most-cancers\/"},"modified":"2022-01-06T11:58:52","modified_gmt":"2022-01-06T08:58:52","slug":"study-bad-cell-copies-lead-to-most-cancers","status":"publish","type":"post","link":"https:\/\/zdmaa.com\/tr\/study-bad-cell-copies-lead-to-most-cancers\/","title":{"rendered":"\u00c7al\u0131\u015fma: K\u00f6t\u00fc h\u00fccre kopyalar\u0131 \u00e7o\u011fu kanser t\u00fcr\u00fcne yol a\u00e7ar"},"content":{"rendered":"

\u00c7al\u0131\u015fma: K\u00f6t\u00fc h\u00fccre kopyalar\u0131 \u00e7o\u011fu kanser t\u00fcr\u00fcne yol a\u00e7ar<\/span><\/span><\/span><\/span><\/p>\n

\n

Herhangi bir kameraya g\u00fcvenirseniz, ba\u015far\u0131s\u0131z oldu\u011funda ne olaca\u011f\u0131n\u0131 bilirsiniz. <\/span>Toneriniz azal\u0131yor, ka\u011f\u0131t s\u0131k\u0131\u015fmalar\u0131 veya orijinal belgenizi akordeon gibi bir \u015feye d\u00f6n\u00fc\u015ft\u00fcr\u00fcyor olsan\u0131z da sonu\u00e7lar i\u015f \u00fcr\u00fcn\u00fcn\u00fcz\u00fc mahvedebilir. <\/span>Daha \u00f6nemli bir \u00f6l\u00e7ekte, her g\u00fcn milyarlarca yeni h\u00fccre kopyas\u0131 \u00fcretmekten sorumlu olan insan v\u00fccudunda benzer ar\u0131zalar meydana gelir. <\/span>Ayn\u0131 anda bu kadar \u00e7ok kopya yap\u0131ld\u0131\u011f\u0131nda, bir \u015feylerin ters gitmesi olas\u0131d\u0131r. <\/span>Bunu yapt\u0131\u011f\u0131n\u0131zda kanser olu\u015fabilir. <\/span>Asl\u0131nda, yeni bir ara\u015ft\u0131rmaya g\u00f6re, bu genellikle b\u00f6yledir.<\/span><\/span><\/p>\n

Phoenix yak\u0131nlar\u0131ndaki hastanemizde kabul doktoru olan Dr. David Boyd, “M\u00fckemmel de\u011filiz” diyor. <\/span>“Bizler canl\u0131 varl\u0131klar\u0131z ve i\u015fler her zaman plana g\u00f6re gitmez. Molek\u00fcllerimizin neye benzemesi gerekti\u011fini biliyoruz, ancak her zaman bu \u015fekilde gitmezler.” <\/span>Deri h\u00fccrelerinin, dokular\u0131n, organlar\u0131n ve di\u011fer materyallerin ya\u015fam\u0131 s\u00fcrd\u00fcren ve yenileyici bir s\u00fcreci olan mitozun bir par\u00e7as\u0131 olarak, v\u00fccuttaki t\u00fcm h\u00fccreler kendilerinin iki kopyas\u0131n\u0131 olu\u015fturur. <\/span>Johns Hopkins \u00dcniversitesi T\u0131p Fak\u00fcltesi’ndeki ara\u015ft\u0131rmac\u0131lar taraf\u0131ndan yap\u0131lan yeni bir ara\u015ft\u0131rma, bu s\u00fcre\u00e7teki replikasyon hatalar\u0131n\u0131n t\u00fcm kanserlerin y\u00fczde 60’\u0131ndan fazlas\u0131ndan sorumlu olabilece\u011fi sonucuna var\u0131yor. <\/span>Johns Hopkins \u00dcniversitesi’nden ortak yazar Christian Tomasetti, “Normal bir h\u00fccre, iki yeni h\u00fccre yapmak i\u00e7in DNA’s\u0131n\u0131 her b\u00f6ld\u00fc\u011f\u00fcnde ve kopyalad\u0131\u011f\u0131nda, bir\u00e7ok hata yapar” dedi. <\/span><\/span>eksen, bir<\/span><\/span><\/em>Johns Hopkins \u00dcniversitesi Blogu. <\/span>“Bu transkripsiyon hatalar\u0131, tarih boyunca bilimsel olarak de\u011feri bilinmeyen g\u00fc\u00e7l\u00fc bir kanser mutasyonu kayna\u011f\u0131d\u0131r.”<\/span><\/span><\/p>\n

Rastgele hatalar, ya\u015fam tarz\u0131 ve genetik.<\/span><\/span><\/h2>\n

32 kanser t\u00fcr\u00fcn\u00fc inceleyen \u00e7al\u0131\u015fma \u015fu sonuca varm\u0131\u015ft\u0131r:<\/span><\/span><\/p>\n

    \n
  • Pankreas kanseri vakalar\u0131n\u0131n \u00e7o\u011funa (y\u00fczde 77) h\u00fccre proliferasyonundaki rastgele hatalar neden olur. <\/span>Gerisi \u00e7evresel veya genetik fakt\u00f6rlere ba\u011flanabilir.<\/span><\/span><\/li>\n
  • Hemen hemen t\u00fcm prostat, beyin veya kemik kanseri vakalar\u0131 (y\u00fczde 95) h\u00fccre transkripsiyonundaki hatalarla ili\u015fkilidir.<\/span><\/span><\/li>\n
  • Akci\u011fer kanseri vakalar\u0131n\u0131n \u00e7o\u011fu sigaradan kaynaklan\u0131r. <\/span>Akci\u011fer kanserlerinin sadece y\u00fczde 35’i h\u00fccre \u00e7o\u011falmas\u0131ndaki hatalara ba\u011flan\u0131yor.<\/span><\/span><\/li>\n
  • T\u00fcm kanserle ilgili mutasyonlar\u0131n y\u00fczde altm\u0131\u015f alt\u0131s\u0131, transkripsiyon hatalar\u0131yla ili\u015fkilidir; <\/span>y\u00fczde 29’u \u00e7evresel veya ya\u015fam tarz\u0131 fakt\u00f6rlerine ba\u011flanabilir; <\/span>Y\u00fczde 5’i genetikten kaynaklan\u0131r.<\/span><\/span><\/li>\n<\/ul>\n

    Dr. Boyd, \u201cBu, olaylar\u0131n oldu\u011fu ve hi\u00e7bir a\u00e7\u0131klaman\u0131z\u0131n olmad\u0131\u011f\u0131 ya\u015fam kategorisine giriyor\u201d diyor. <\/span>“Mutlaka her \u015feyi do\u011fru yapan hastalar\u0131m\u0131z var. Do\u011fru yiyorlar. Egzersiz yap\u0131yorlar. Organik madde ortak dil haline gelmeden \u00f6nce organik madde yiyorlard\u0131, ama sonunda kanser oldular. Tan\u0131 konuldu\u011funda, insanlar\u0131n bakmak istemesi yayg\u0131nd\u0131r. Neyi yanl\u0131\u015f yapt\u0131klar\u0131n\u0131 bulmak i\u00e7in. Ama bazen bir sebep arars\u0131n ve o orada de\u011fildir.”<\/span><\/span><\/p>\n

    Hasarl\u0131 kopyalar\u0131 onar\u0131n<\/span><\/span><\/h2>\n

    Bir h\u00fccrenin yanl\u0131\u015f kopyay\u0131 t\u00fck\u00fcrmesi kansere neden oldu\u011fu anlam\u0131na gelmez. <\/span>K\u00f6t\u00fc, onar\u0131lamaz h\u00fccrelerin \u00e7o\u011fu kendilerini \u00f6ld\u00fcr\u00fcr. <\/span>Ama \u00f6nce, v\u00fccut onu d\u00fczeltmek i\u00e7in \u00e7al\u0131\u015f\u0131r. <\/span>H\u00fccrelerin hasar\u0131 kontrol etme yollar\u0131ndan biri, poli-ADP-riboz polimeraz (PARP) ad\u0131 verilen bir proteindir. <\/span>Bu enzim, h\u00fccre olu\u015fturma y\u00f6neticisi olarak g\u00f6rev yapar ve genetik onar\u0131m ekiplerini hasarl\u0131 DNA’y\u0131 onarmaya y\u00f6nlendirir. <\/span>Dr. Boyd, “Biz harika varl\u0131klar\u0131z ve bu sorunlar\u0131 tespit eden bir inceleme sistemimiz var. Ve bu sorunlar\u0131n yakla\u015f\u0131k y\u00fczde 99’unu d\u00fczeltiyor. Bu genellikle normal h\u00fccre i\u015flevi i\u00e7in yeterlidir” diyor.<\/span><\/span><\/p>\n

    Dr. Boyd, rastgele mutasyonlar, genler ve h\u00fccre replikasyon hatalar\u0131n\u0131n yan\u0131 s\u0131ra, insanlar\u0131n kanseri \u00f6nlemeye yard\u0131mc\u0131 olmak i\u00e7in atabilecekleri birka\u00e7 ad\u0131m oldu\u011funu s\u00f6yl\u00fcyor. <\/span>\u201cMaksimize etmek istemezsiniz\u201d diyor. <\/span>“\u015eans\u0131n\u0131z\u0131 art\u0131rabilecek d\u0131\u015f etkenlere sahip olmak istemezsiniz. T\u00fcm do\u011fru \u015feyleri yapmak i\u00e7in ba\u015fka bir neden: do\u011fru yiyin, egzersiz yap\u0131n, stresi azalt\u0131n, d\u00fczenli olarak doktorunuza g\u00f6r\u00fcn\u00fcn, g\u00fcne\u015f kremi s\u00fcr\u00fcn ve g\u00fcvenli seks yap\u0131n.” <\/span>Johns Hopkins \u00e7al\u0131\u015fmas\u0131n\u0131n ortak yazar\u0131 ve Johns Hopkins Kimmel Kanser Merkezi’ndeki Ludwig Merkezi’nin e\u015f direkt\u00f6r\u00fc Dr. Bert Vogelstein, kanseri \u00f6nlemenin odak noktas\u0131 olarak kalmas\u0131 gerekti\u011fini s\u00f6yl\u00fcyor, ancak ara\u015ft\u0131rmas\u0131n\u0131n erken te\u015fhisin iyile\u015ftirilmesi ihtiyac\u0131n\u0131n alt\u0131n\u0131 \u00e7izdi\u011fini ekliyor. <\/span>\u201c\u0130nsanlar\u0131 kanserli mutasyonlar geli\u015ftirme riskini art\u0131ran \u00e7evresel fakt\u00f6rlerden ve ya\u015fam tarzlar\u0131ndan ka\u00e7\u0131nmaya te\u015fvik etmeye devam etmeliyiz\u201d dedi. <\/span><\/span>Merkez<\/span><\/span><\/em>. <\/span>“Ancak, DNA kopyalamadaki bu rastgele hatalar nedeniyle bir\u00e7ok insan kanser geli\u015ftirmeye devam edecek ve hala tedavi edilebilirken t\u00fcm kanserleri erken tespit etmek i\u00e7in acilen daha iyi y\u00f6ntemlere ihtiya\u00e7 var.”<\/span><\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

    \u00c7al\u0131\u015fma: K\u00f6t\u00fc h\u00fccre kopyalar\u0131 \u00e7o\u011fu kanser t\u00fcr\u00fcne yol a\u00e7ar Herhangi bir kameraya g\u00fcvenirseniz, ba\u015far\u0131s\u0131z oldu\u011funda ne olaca\u011f\u0131n\u0131 bilirsiniz. Toneriniz azal\u0131yor, ka\u011f\u0131t s\u0131k\u0131\u015fmalar\u0131 veya orijinal belgenizi akordeon gibi bir \u015feye d\u00f6n\u00fc\u015ft\u00fcr\u00fcyor olsan\u0131z da sonu\u00e7lar i\u015f \u00fcr\u00fcn\u00fcn\u00fcz\u00fc mahvedebilir. Daha \u00f6nemli bir \u00f6l\u00e7ekte, her g\u00fcn milyarlarca yeni h\u00fccre kopyas\u0131 \u00fcretmekten sorumlu olan insan v\u00fccudunda benzer ar\u0131zalar meydana gelir. …<\/p>\n","protected":false},"author":1,"featured_media":17095,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-17628","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-tr"],"yoast_head":"\n\u00c7al\u0131\u015fma: K\u00f6t\u00fc h\u00fccre kopyalar\u0131 \u00e7o\u011fu kanser t\u00fcr\u00fcne yol a\u00e7ar - zdmaa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zdmaa.com\/tr\/study-bad-cell-copies-lead-to-most-cancers\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c7al\u0131\u015fma: K\u00f6t\u00fc h\u00fccre kopyalar\u0131 \u00e7o\u011fu kanser t\u00fcr\u00fcne yol a\u00e7ar - zdmaa\" \/>\n<meta property=\"og:description\" content=\"\u00c7al\u0131\u015fma: K\u00f6t\u00fc h\u00fccre kopyalar\u0131 \u00e7o\u011fu kanser t\u00fcr\u00fcne yol a\u00e7ar Herhangi bir kameraya g\u00fcvenirseniz, ba\u015far\u0131s\u0131z oldu\u011funda ne olaca\u011f\u0131n\u0131 bilirsiniz. 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Toneriniz azal\u0131yor, ka\u011f\u0131t s\u0131k\u0131\u015fmalar\u0131 veya orijinal belgenizi akordeon gibi bir \u015feye d\u00f6n\u00fc\u015ft\u00fcr\u00fcyor olsan\u0131z da sonu\u00e7lar i\u015f \u00fcr\u00fcn\u00fcn\u00fcz\u00fc mahvedebilir. 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