{"id":18223,"date":"2022-01-06T14:24:56","date_gmt":"2022-01-06T11:24:56","guid":{"rendered":"https:\/\/zdmaa.com\/immunotherapy-drug-triggers-cascading-immune-response\/"},"modified":"2022-01-07T02:02:27","modified_gmt":"2022-01-06T23:02:27","slug":"immunotherapy-drug-triggers-cascading-immune-response","status":"publish","type":"post","link":"https:\/\/zdmaa.com\/tr\/immunotherapy-drug-triggers-cascading-immune-response\/","title":{"rendered":"\u0130mm\u00fcnoterapi, imm\u00fcn yan\u0131t\u0131n kademeli ila\u00e7 ind\u00fckleyicileri"},"content":{"rendered":"

\u0130mm\u00fcnoterapi, imm\u00fcn yan\u0131t\u0131n kademeli ila\u00e7 ind\u00fckleyicileri<\/span><\/span><\/span><\/span><\/p>\n

\n

Ara\u015ft\u0131rmac\u0131lar, ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin kansere kar\u015f\u0131 cephaneli\u011fine yeni bir ara\u00e7 ekleyebilecek bir imm\u00fcnoterapi ilac\u0131 \u00fczerinde bir \u00e7al\u0131\u015fma ba\u015flatt\u0131. <\/span>Ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin ekstra yard\u0131ma ihtiyac\u0131 vard\u0131r, \u00e7\u00fcnk\u00fc kanseri her zaman bir tehdit olarak alg\u0131lamaz ve h\u00fccreleri, d\u00f6n\u00fc\u015fm\u00fc\u015f olduklar\u0131 zararl\u0131 mutasyonlar olarak de\u011fil, v\u00fccudun kendisine ait olarak g\u00f6r\u00fcr. <\/span>Bu nedenle kanser h\u00fccreleri, v\u00fccut sa\u011fl\u0131\u011f\u0131na y\u00f6nelik risklerini \u00f6l\u00e7mek i\u00e7in h\u00fccreleri “izledikleri” i\u00e7in “kontrol noktalar\u0131” olarak adland\u0131r\u0131lan protein molek\u00fcllerinden ge\u00e7ti\u011finde, kanser h\u00fccreleri, normal h\u00fccreleri taklit eden aldat\u0131c\u0131 sinyaller g\u00f6nderir. fark edilmeden ge\u00e7melerine izin verir.<\/span><\/span><\/p>\n

Kontrol noktas\u0131 inhibit\u00f6rleri olarak bilinen umut verici bir imm\u00fcnoterapi ila\u00e7lar\u0131 s\u0131n\u0131f\u0131, bu sinyalleri bozarak, kanser h\u00fccrelerini ba\u011f\u0131\u015f\u0131kl\u0131k sistemine maruz b\u0131rakarak ve potansiyel bir sald\u0131r\u0131 ba\u015flatarak \u00e7al\u0131\u015f\u0131r. <\/span>\u015eu anda piyasada bulunan imm\u00fcnoterapi ila\u00e7lar\u0131, \u00fc\u00e7 kontrol noktas\u0131 al\u0131c\u0131s\u0131n\u0131 hedefliyor: PD-1, PD-L1 ve CLTA-4. <\/span>Bu kontrol noktas\u0131 inhibit\u00f6rleri \u015fu anda ileri melanom, k\u00fc\u00e7\u00fck h\u00fccreli olmayan akci\u011fer kanseri, renal h\u00fccreli karsinom, Hodgkin lenfoma, mesane kanseri ve\/veya ba\u015f ve boyun skuam\u00f6z h\u00fccreli karsinomas\u0131 i\u00e7in onaylanm\u0131\u015ft\u0131r.<\/span><\/span><\/p>\n

Yeni se\u00e7enekleri ke\u015ffedin<\/span><\/span><\/h2>\n

Yeni bir Faz 1 denemesi, \u015fu anda TSR-022 olarak adland\u0131r\u0131lan ve hen\u00fcz onaylanm\u0131\u015f bir ila\u00e7 i\u00e7in hedef olmayan ba\u015fka bir kontrol noktas\u0131n\u0131 engellemeye \u00e7al\u0131\u015fan bir ilac\u0131 inceliyor: TIM-3. <\/span>Phoenix yak\u0131nlar\u0131ndaki hastanemizde klinik ara\u015ft\u0131rma ve faz I ve II klinik deneyler direkt\u00f6r\u00fc ve \u00e7al\u0131\u015fman\u0131n ba\u015f ara\u015ft\u0131rmac\u0131s\u0131 Dr. Glenn Weiss, \u201cBir\u00e7ok \u015feyi ba\u015farmay\u0131 umuyoruz\u201d diyor. <\/span>“\u0130lerlemi\u015f kanserli hastalar\u0131m\u0131z i\u00e7in yeni tedavi se\u00e7eneklerini ara\u015ft\u0131rmak, bir ilac\u0131n ne kadar g\u00fcvenli oldu\u011funu ve nas\u0131l dozlanmas\u0131 gerekti\u011fini belirlemek ve uzun vadeli sonu\u00e7lara yol a\u00e7\u0131p a\u00e7mad\u0131\u011f\u0131n\u0131 g\u00f6rmek istiyoruz.”<\/span><\/span><\/p>\n

TSR-022’yi onaylanm\u0131\u015f kontrol noktas\u0131 inhibit\u00f6rlerinden ay\u0131ran \u015fey, bir ba\u011f\u0131\u015f\u0131kl\u0131k tepkisi ortaya \u00e7\u0131kard\u0131\u011f\u0131 takdirde \u00fcretebilece\u011fi potansiyel basamaklama etkisidir. <\/span>Amerikan Kanser Ara\u015ft\u0131rmalar\u0131 Derne\u011fi (AACR) taraf\u0131ndan 2014 y\u0131l\u0131nda yay\u0131nlanan bir makaleye g\u00f6re, TIM-3 resept\u00f6rleri yaln\u0131zca t\u00fcm\u00f6rlerdeki T h\u00fccrelerinde bulunmaz, ayn\u0131 zamanda t\u00fcm\u00f6rlerde k\u0131sa devreye neden olabilecek di\u011fer h\u00fccrelerin varl\u0131\u011f\u0131yla da ba\u011flant\u0131l\u0131d\u0131r. <\/span>ba\u011f\u0131\u015f\u0131kl\u0131k sistemi. <\/span>ve\/veya t\u00fcm\u00f6r b\u00fcy\u00fcmesini te\u015fvik eder. <\/span>Bu nedenle, TIM-3’\u00fc hedeflemek yaln\u0131zca T h\u00fccrelerini yeniden aktive etmekle kalmaz, ayn\u0131 zamanda mevcut imm\u00fcnoterapi ila\u00e7lar\u0131n\u0131n tasar\u0131m\u0131n\u0131n \u00f6tesinde ba\u015fka h\u00fccresel etkile\u015fimlerin kurulmas\u0131na da yol a\u00e7ar. <\/span>\u00d6rne\u011fin:<\/span><\/span><\/p>\n

    \n
  • Bilim adamlar\u0131, TIM-3’\u00fcn t\u00fcm\u00f6r mikro-ortam\u0131 etraf\u0131nda toplanan ve ba\u011f\u0131\u015f\u0131kl\u0131k sistemini bask\u0131layan d\u00fczenleyici T h\u00fccrelerini (Treg’ler) \u00e7ekebilece\u011fine inan\u0131yor. <\/span>T h\u00fccrelerinin bozulmas\u0131n\u0131 \u00f6nlemek i\u00e7in ba\u011f\u0131\u015f\u0131kl\u0131k sistemi i\u00e7in Treg’ler gereklidir.<\/span><\/span><\/li>\n
  • Baz\u0131 ara\u015ft\u0131rmalar, TIM-3’\u00fcn miyeloid t\u00fcrevli bask\u0131lay\u0131c\u0131 h\u00fccrelerin varl\u0131\u011f\u0131n\u0131 art\u0131rabilece\u011fini \u00f6ne s\u00fcr\u00fcyor. <\/span>Bu h\u00fccreler ba\u011f\u0131\u015f\u0131kl\u0131k sistemini d\u00fczenlemeye yard\u0131mc\u0131 olur, ancak kanser tedavilerine verilen zay\u0131f yan\u0131ttan da sorumlu olabilirler.<\/span><\/span><\/span><\/span><\/li>\n
  • TIM-3, dendritik h\u00fccrelerde bulunur ve onlar\u0131n bir ba\u011f\u0131\u015f\u0131kl\u0131k tepkisi ba\u015flatmas\u0131n\u0131 \u00f6nleyebilir. <\/span>Dendritik h\u00fccreler, ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin trafik polisi gibidir ve istilac\u0131lara sald\u0131rmak i\u00e7in T h\u00fccrelerini do\u011fru y\u00f6ne g\u00f6nderir.<\/span><\/span><\/span><\/span><\/li>\n<\/ul>\n

    PD-1 inhibit\u00f6rleri nas\u0131l \u00e7al\u0131\u015f\u0131r?<\/span><\/span><\/span><\/span><\/h2>\n

    PD-1 kontrol noktas\u0131 inhibit\u00f6rleri, sebep-sonu\u00e7 ili\u015fkisi i\u00e7inde \u00e7al\u0131\u015facak \u015fekilde tasarlanm\u0131\u015ft\u0131r. <\/span>PD-1 kontrol noktas\u0131nda kanser h\u00fccresi ile ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccresi aras\u0131ndaki ileti\u015fimi bloke eder ve bu da kanser h\u00fccrelerine sald\u0131r\u0131ya yol a\u00e7ar. <\/span>diyor. <\/span>Vice’\u0131n TSR-022’si “daha geni\u015f bir etkiye sahip olacak \u015fekilde tasarlanm\u0131\u015ft\u0131r.” <\/span>TIM-3’\u00fc bloke eder ve potansiyel etkile\u015fim, birer birer d\u00fc\u015fen ve kanser h\u00fccrelerini birden fazla sald\u0131r\u0131ya a\u00e7an bir dizi h\u00fccresel dominoya benzeyebilir.<\/span><\/span><\/span><\/span><\/p>\n

    AACR makalesinde, TIM-3’\u00fcn melanom, k\u00fc\u00e7\u00fck h\u00fccreli olmayan akci\u011fer kanseri ve Hodgkin olmayan lenfoma hastalar\u0131nda mevcut oldu\u011fu belirtiliyor, ancak bu deneme, \u00f6nceki antikanser tedavileriyle ilgili di\u011fer \u00f6zel gereksinimleri kar\u015f\u0131layan kat\u0131 t\u00fcm\u00f6rleri olan yeti\u015fkin hastalar\u0131 i\u00e7eriyor. <\/span>Deneme, TSR-022’nin tek ba\u015f\u0131na ve bir PD-1 inhibit\u00f6r\u00fc ile birlikte nas\u0131l \u00e7al\u0131\u015ft\u0131\u011f\u0131n\u0131 inceler. <\/span>Phoenix yak\u0131nlar\u0131ndaki hastanemiz, d\u00fcnyada TSR-022’yi bir faz I klinik ara\u015ft\u0131rman\u0131n par\u00e7as\u0131 olarak uygulayan ilk tesisti.TSR-022, TESARO Inc. taraf\u0131ndan geli\u015ftirildi. <\/span>AnaptysBio Inc. ile birlikte Waltham, Massachusetts’te <\/span>San Diego’da.<\/span><\/span><\/p>\n

    \u0130mm\u00fcnoterapinin arkas\u0131ndaki bilim hakk\u0131nda daha fazla bilgi edinin.<\/span><\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

    \u0130mm\u00fcnoterapi, imm\u00fcn yan\u0131t\u0131n kademeli ila\u00e7 ind\u00fckleyicileri Ara\u015ft\u0131rmac\u0131lar, ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin kansere kar\u015f\u0131 cephaneli\u011fine yeni bir ara\u00e7 ekleyebilecek bir imm\u00fcnoterapi ilac\u0131 \u00fczerinde bir \u00e7al\u0131\u015fma ba\u015flatt\u0131. Ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin ekstra yard\u0131ma ihtiyac\u0131 vard\u0131r, \u00e7\u00fcnk\u00fc kanseri her zaman bir tehdit olarak alg\u0131lamaz ve h\u00fccreleri, d\u00f6n\u00fc\u015fm\u00fc\u015f olduklar\u0131 zararl\u0131 mutasyonlar olarak de\u011fil, v\u00fccudun kendisine ait olarak g\u00f6r\u00fcr. Bu nedenle kanser h\u00fccreleri, v\u00fccut …<\/p>\n","protected":false},"author":1,"featured_media":17925,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-18223","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-tr"],"yoast_head":"\n\u0130mm\u00fcnoterapi, imm\u00fcn yan\u0131t\u0131n kademeli ila\u00e7 ind\u00fckleyicileri - zdmaa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zdmaa.com\/tr\/immunotherapy-drug-triggers-cascading-immune-response\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u0130mm\u00fcnoterapi, imm\u00fcn yan\u0131t\u0131n kademeli ila\u00e7 ind\u00fckleyicileri - zdmaa\" \/>\n<meta property=\"og:description\" content=\"\u0130mm\u00fcnoterapi, imm\u00fcn yan\u0131t\u0131n kademeli ila\u00e7 ind\u00fckleyicileri Ara\u015ft\u0131rmac\u0131lar, ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin kansere kar\u015f\u0131 cephaneli\u011fine yeni bir ara\u00e7 ekleyebilecek bir imm\u00fcnoterapi ilac\u0131 \u00fczerinde bir \u00e7al\u0131\u015fma ba\u015flatt\u0131. 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Ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin ekstra yard\u0131ma ihtiyac\u0131 vard\u0131r, \u00e7\u00fcnk\u00fc kanseri her zaman bir tehdit olarak alg\u0131lamaz ve h\u00fccreleri, d\u00f6n\u00fc\u015fm\u00fc\u015f olduklar\u0131 zararl\u0131 mutasyonlar olarak de\u011fil, v\u00fccudun kendisine ait olarak g\u00f6r\u00fcr. 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