{"id":18301,"date":"2022-01-06T14:05:35","date_gmt":"2022-01-06T11:05:35","guid":{"rendered":"https:\/\/zdmaa.com\/whats-the-difference-between-genetics-and-genomics\/"},"modified":"2022-01-07T02:33:01","modified_gmt":"2022-01-06T23:33:01","slug":"whats-the-difference-between-genetics-and-genomics","status":"publish","type":"post","link":"https:\/\/zdmaa.com\/tr\/whats-the-difference-between-genetics-and-genomics\/","title":{"rendered":"Genetik ve genomik aras\u0131ndaki fark nedir?"},"content":{"rendered":"

Genetik ve genomik aras\u0131ndaki fark nedir?<\/span><\/span><\/span><\/span><\/p>\n

\n

Birbirlerinin yerine kullan\u0131lsalar da, “genetik” ve “genomik” terimleri e\u015fanlaml\u0131 de\u011fildir. <\/span>Her ikisi de genetik materyalin incelenmesini i\u00e7erir ve her ikisi de <\/span>do\u011fum veya k\u00f6ken anlam\u0131na <\/span>gelen Yunanca <\/span><\/span>gen<\/span><\/span><\/em> kelimesinden t\u00fcretilmi\u015ftir <\/span>. <\/span>Ancak benzerlikler b\u00fcy\u00fck \u00f6l\u00e7\u00fcde burada bitiyor. <\/span>Genetik ve genomik karma\u015f\u0131k konular olsa da, aralar\u0131ndaki fark \u00e7ok daha basittir: biri (genetik), bir <\/span><\/span>ki\u015finin<\/span><\/span><\/em> genetik yap\u0131s\u0131n\u0131n genellikle kullan\u0131ld\u0131\u011f\u0131 <\/span>bir tanesini <\/span>, di\u011feri (genomik) ise bir <\/span><\/span>t\u00fcm\u00f6r<\/span><\/span><\/em> molek\u00fcler yap\u0131s\u0131n\u0131 <\/span>ifade eder <\/span>. <\/span>Genleri kal\u0131tsal \u00f6zellikler ve genomikleri kansere \u00f6zg\u00fc mutasyonlar a\u00e7\u0131s\u0131ndan da d\u00fc\u015f\u00fcnebilirsiniz.<\/span><\/span><\/p>\n

Onlar neler<\/span><\/span><\/h2>\n

Genetik, insanlar\u0131n do\u011fumda miras ald\u0131klar\u0131 ve ailelerinden nesiller boyunca aktar\u0131lan genlerin incelenmesidir. <\/span>\u0130nsan v\u00fccudundaki her h\u00fccre, bir DNA dizisinin tamam\u0131n\u0131 i\u00e7erir ve her bir dizi, mavi g\u00f6zler, k\u0131z\u0131l sa\u00e7lar veya belki de baz\u0131 kanser t\u00fcrlerine yakalanma olas\u0131l\u0131\u011f\u0131n\u0131n artmas\u0131 gibi belirli \u00f6zellikler i\u00e7in talimatlar ta\u015f\u0131yan genlerle doludur. <\/span>Genetik testler, bir ki\u015finin kanser ve di\u011fer hastal\u0131klara yakalanma riskini belirlemeye yard\u0131mc\u0131 olabilir.<\/span><\/span><\/p>\n

Genomik genellikle, kanserin ne kadar agresif oldu\u011fundan v\u00fccudun uzak b\u00f6lgelerine yay\u0131l\u0131p yay\u0131lmad\u0131\u011f\u0131na kadar farkl\u0131 kanser davran\u0131\u015flar\u0131na neden olabilen genlerdeki mutasyonlar\u0131n incelenmesini ifade eder. <\/span>\u0130nsan v\u00fccudundaki her h\u00fccre on binlerce gen i\u00e7erir, ancak tek bir gendeki mutasyonlar h\u00fccrelerin kontrolden \u00e7\u0131kmas\u0131na ve t\u00fcm\u00f6rlerin b\u00fcy\u00fcmesine neden olabilir. <\/span>\u00c7o\u011fu zaman, bir t\u00fcm\u00f6rdeki h\u00fccreler, genleri mutasyona u\u011framaya devam etti\u011fi i\u00e7in zamanla de\u011fi\u015fir. <\/span>Bu nedenle, genetik testler, ayn\u0131 t\u00fcm\u00f6r \u00fczerinde yap\u0131ld\u0131\u011f\u0131nda bile zaman i\u00e7inde b\u00fcy\u00fck \u00f6l\u00e7\u00fcde de\u011fi\u015febilir. <\/span>T\u00fcm\u00f6r\u00fcn molek\u00fcler yap\u0131s\u0131 de\u011fi\u015fti\u011finde, hasta belirli bir tedaviye diren\u00e7 geli\u015ftirebilir. <\/span>Philadelphia’daki hastanemizde lisansl\u0131 sertifikal\u0131 bir genetik dan\u0131\u015fman olan Melanie Korpman, “Ne yaz\u0131k ki, kanser \u00e7ok zekidir ve kanser art\u0131k farkl\u0131 bir kanser oldu\u011fu i\u00e7in tedavinin \u00e7al\u0131\u015fmay\u0131 b\u0131rakmas\u0131 yayg\u0131nd\u0131r” diyor.<\/span><\/span><\/p>\n

Testler ne g\u00f6steriyor?<\/span><\/span><\/h2>\n

Genetik ve genomik testler \u00e7ok farkl\u0131 \u015fekillerde ve \u00e7ok farkl\u0131 ko\u015fullarda kullan\u0131lsa da, her iki test de (bir ki\u015finin DNA profilini haritalayan ve bir t\u00fcm\u00f6rdeki genetik anormallikleri arayanlar) kanserin tedavisinde yard\u0131mc\u0131 olabilir. <\/span>Kanser d\u00fcnyas\u0131nda, genetik testler, bir hastan\u0131n ailesinden miras alm\u0131\u015f olabilece\u011fi genetik mutasyonlar\u0131 arar; bu nedenle, ailesinde belirli bir kanser t\u00fcr\u00fc \u00f6yk\u00fcs\u00fc olan ki\u015filere \u00f6nerilir. <\/span>\u00d6rne\u011fin, bir BRCA1 gen mutasyonu i\u00e7in pozitif test edenlerin meme ve yumurtal\u0131k kanseri geli\u015ftirme riski artar.<\/span><\/span><\/p>\n

Genomik testler, kal\u0131t\u0131mla ilgisi olmayan, ancak kanser h\u00fccresinin kendisinde, ya t\u00fct\u00fcn kullan\u0131m\u0131 ya da g\u00fcne\u015f \u0131\u015f\u0131\u011f\u0131na maruz kalma gibi d\u0131\u015f bir nedene ya da i\u00e7sel bir fakt\u00f6re ba\u011fl\u0131 olarak meydana gelen mutasyonlar\u0131 rastgele molek\u00fcler olarak tan\u0131mlamak i\u00e7in kullan\u0131l\u0131r. kanser h\u00fccresinde de\u011fi\u015fiklik. <\/span>H\u00fccre – zindan. <\/span>h\u00fccre. <\/span>Bu de\u011fi\u015fiklikler, bir t\u00fcm\u00f6r\u00fcn neden b\u00fcy\u00fcd\u00fc\u011f\u00fc veya yay\u0131ld\u0131\u011f\u0131 gibi neden b\u00f6yle davrand\u0131\u011f\u0131n\u0131 belirleyebilir. <\/span>Mutasyon bilinen bir anormallikle e\u015fle\u015firse, onkolo\u011funuz bu mutasyonu hedeflemek i\u00e7in tasarlanm\u0131\u015f belirli bir hedefe y\u00f6nelik tedavi \u00f6nerebilir. <\/span>Bu t\u00fcr bir test, kanseri yan\u0131t vermeyi b\u0131rakan veya kemoterapi ve radyasyon gibi geleneksel tedavilere iyi yan\u0131t vermeyen ki\u015filer i\u00e7in \u00f6nerilebilir.<\/span><\/span><\/p>\n

Tedaviyi nas\u0131l y\u00f6nlendirirler?<\/span><\/span><\/h2>\n

Hem genetik hem de epigenetik testlerde, onkolo\u011funuz sonu\u00e7lar\u0131n\u0131za g\u00f6re, \u00f6rne\u011fin genetik test durumunda koruyucu cerrahi veya genetik test durumunda belirli bir ila\u00e7 tedavisi t\u00fcr\u00fc gibi tedavi \u00f6nerebilir. <\/span>\u00c7o\u011fu kanser, kal\u0131tsal genlerden de\u011fil, hastalar\u0131n ya\u015famlar\u0131 boyunca meydana gelen mutasyonlardan geli\u015fti\u011finden, ara\u015ft\u0131rmac\u0131lar, genomik testlerde devam eden ilerlemelerin, spesifik t\u00fcm\u00f6r mutasyonlar\u0131n\u0131 ve her bireye \u00f6zel tedavileri daha iyi tan\u0131mlamaya yard\u0131mc\u0131 olaca\u011f\u0131n\u0131 umuyorlar.<\/span><\/span><\/p>\n

Kanser tedavilerini daha iyi anlamak i\u00e7in genomik testleri kullanan bir klinik ara\u015ft\u0131rma, TAPUR \u00e7al\u0131\u015fmas\u0131d\u0131r. <\/span>TAPUR veya Hedefli Ajan Kullan\u0131m\u0131 ve Karakterizasyon \u00c7al\u0131\u015fmas\u0131, ila\u00e7lar\u0131 genetik mutasyonlara sahip t\u00fcm\u00f6rlerle e\u015fle\u015ftirerek, ticari olarak temin edilebilen kanser ila\u00e7lar\u0131n\u0131n daha geni\u015f bir kanser yelpazesinde nas\u0131l \u00e7al\u0131\u015ft\u0131\u011f\u0131na dair anlay\u0131\u015f\u0131m\u0131z\u0131 geli\u015ftirmeyi ama\u00e7layan bir klinik \u00e7al\u0131\u015fmad\u0131r. <\/span>.<\/span><\/span><\/p>\n

Yenilik\u00e7i bir genetik teknolojisi olan CRISPR hakk\u0131nda daha fazla bilgi edinin.<\/span><\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Genetik ve genomik aras\u0131ndaki fark nedir? Birbirlerinin yerine kullan\u0131lsalar da, “genetik” ve “genomik” terimleri e\u015fanlaml\u0131 de\u011fildir. Her ikisi de genetik materyalin incelenmesini i\u00e7erir ve her ikisi de do\u011fum veya k\u00f6ken anlam\u0131na gelen Yunanca gen kelimesinden t\u00fcretilmi\u015ftir . Ancak benzerlikler b\u00fcy\u00fck \u00f6l\u00e7\u00fcde burada bitiyor. Genetik ve genomik karma\u015f\u0131k konular olsa da, aralar\u0131ndaki fark \u00e7ok daha basittir: …<\/p>\n","protected":false},"author":1,"featured_media":17888,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-18301","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-tr"],"yoast_head":"\nGenetik ve genomik aras\u0131ndaki fark nedir? - zdmaa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zdmaa.com\/tr\/whats-the-difference-between-genetics-and-genomics\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Genetik ve genomik aras\u0131ndaki fark nedir? - zdmaa\" \/>\n<meta property=\"og:description\" content=\"Genetik ve genomik aras\u0131ndaki fark nedir? 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