{"id":18651,"date":"2022-01-06T13:03:56","date_gmt":"2022-01-06T10:03:56","guid":{"rendered":"https:\/\/zdmaa.com\/how-cancer-uses-normal-cells-for-its-needs\/"},"modified":"2022-01-07T08:56:03","modified_gmt":"2022-01-07T05:56:03","slug":"how-cancer-uses-normal-cells-for-its-needs","status":"publish","type":"post","link":"https:\/\/zdmaa.com\/tr\/how-cancer-uses-normal-cells-for-its-needs\/","title":{"rendered":"Kanser, ihtiya\u00e7lar\u0131 i\u00e7in normal h\u00fccreleri nas\u0131l kullan\u0131r?"},"content":{"rendered":"

Kanser, ihtiya\u00e7lar\u0131 i\u00e7in normal h\u00fccreleri nas\u0131l kullan\u0131r?<\/span><\/span><\/span><\/span><\/p>\n

\n

Kurnaz kanser h\u00fccreleri, geli\u015fmek ve hayatta kalmak s\u00f6z konusu oldu\u011funda genellikle neyin i\u015fe yaray\u0131p neyin yaramad\u0131\u011f\u0131n\u0131 bilir. <\/span>D\u00fczensiz h\u00fccreler b\u00f6l\u00fcnmek, b\u00fcy\u00fcmek ve bazen uzak organlara seyahat etmek i\u00e7in normal h\u00fccresel davran\u0131\u015f kurallar\u0131n\u0131 \u00e7i\u011fnerken, sa\u011fl\u0131kl\u0131 h\u00fccrelerin hain g\u00fcndemlerini ilerletmek i\u00e7in kulland\u0131klar\u0131 baz\u0131 normal i\u015flevleri de benimserler. <\/span>Philadelphia’daki Hastanemizde cerrahi \u015fefi ve jinekolojik onkoloji ve robotik cerrahi direkt\u00f6r\u00fc Justin Chura, “Bu h\u00fccresel i\u015flevler bizim i\u00e7in iyidir, ancak kanser h\u00fccreleri i\u00e7in de iyidir” diyor.<\/span><\/span><\/p>\n

Kanser h\u00fccrelerinde bu davran\u0131\u015f\u0131 durdurmak i\u00e7in doktorlar inhibit\u00f6r denilen ila\u00e7lar\u0131 kullanabilirler. <\/span>\u0130simlerine uygun olarak inhibit\u00f6rler, h\u00fccreler i\u00e7indeki belirli eylemleri engellemek i\u00e7in tasarlanm\u0131\u015ft\u0131r ve \u00e7o\u011fu durumda belirli enzimleri hedefler. <\/span>Bu enzimlerle oynamak, deri d\u00f6k\u00fcnt\u00fcleri ve sindirim rahats\u0131zl\u0131klar\u0131ndan y\u00fcksek tansiyon ve otoimm\u00fcn hastal\u0131klara kadar y\u00f6netilmesi veya tedavi edilmesi gereken \u00e7ok \u00e7e\u015fitli yan etkilere yol a\u00e7abilir.<\/span><\/span><\/p>\n

Engelleyici ila\u00e7lar nelerdir?<\/span><\/span><\/h2>\n

\u0130nhibit\u00f6r ila\u00e7lar, \u00e7e\u015fitli hastal\u0131k ve durumlar\u0131 tedavi etmek i\u00e7in kullan\u0131l\u0131r. <\/span>Omeprazol (Prelosak <\/span><\/span>\u00ae<\/span><\/span><\/sup> ), \u00f6rne\u011fin midede asidi serbest b\u0131rakan enzimi \u00f6nleyen bir <\/span>proton pompas\u0131 inhibit\u00f6r\u00fc. <\/span>Baz\u0131 mide \u00fclserlerini ve asit refl\u00fc hastal\u0131\u011f\u0131n\u0131 tedavi etmek i\u00e7in kullan\u0131l\u0131r. <\/span>Son y\u0131llarda, ABD G\u0131da ve \u0130la\u00e7 Dairesi kanserle sava\u015fan yeni inhibit\u00f6r ila\u00e7lar\u0131 onaylad\u0131. <\/span>\u0130lk olarak 2010 y\u0131l\u0131nda onaylanan kontrol noktas\u0131 inhibit\u00f6rleri, cilt kanseri ve akci\u011fer kanseri gibi tedavisi zor baz\u0131 kanserlerle m\u00fccadelede umut verici sonu\u00e7lar g\u00f6stermi\u015ftir. <\/span>Bu ila\u00e7lar, kanser h\u00fccrelerinin ba\u011f\u0131\u015f\u0131kl\u0131k sisteminden saklanmas\u0131na yard\u0131mc\u0131 olan sinyal resept\u00f6rlerini bloke eder. <\/span>\u0130nhibit\u00f6rler ve <\/span>yayg\u0131n olan ila\u00e7lar kontrol noktalar\u0131nda Bembroleezzomab (Keytruda olan <\/span><\/span>\u00ae<\/span><\/span><\/sup> ) ve Nivolumab (Opdivo <\/span><\/span>\u00ae<\/span><\/span><\/sup> ).<\/span><\/span><\/p>\n

Kanseri tedavi etmek i\u00e7in kullan\u0131labilecek di\u011fer yayg\u0131n inhibit\u00f6r ila\u00e7lara \u00f6rnekler:<\/span><\/span><\/p>\n

PARP inhibit\u00f6rleri:<\/span><\/span><\/strong>Yumurtal\u0131k kanseri i\u00e7in yeni bir tedavi olan bu ila\u00e7lar, kanser h\u00fccrelerinin DNA’lar\u0131ndaki hasar\u0131 onarmas\u0131n\u0131 \u00f6nlemek i\u00e7in tasarlanm\u0131\u015ft\u0131r. <\/span>Hasar tamir edilmedi\u011finde h\u00fccreler \u00f6lebilir. <\/span>H\u00fccreler, DNA’lar\u0131na zarar verebilecek kimyasallar veya g\u00fcne\u015f \u0131\u015f\u0131\u011f\u0131 gibi d\u0131\u015f g\u00fc\u00e7lerin s\u00fcrekli sald\u0131r\u0131s\u0131 alt\u0131ndad\u0131r. <\/span>H\u00fccre b\u00f6l\u00fcnmesi ayr\u0131ca DNA replikasyonunda hatalara neden olabilir. <\/span>Normal veya kanserli h\u00fccreler, poli-ADP-riboz polimeraz (PARP) ad\u0131 verilen bir protein ile hasar\u0131 izleyebilir ve hasar\u0131 onarmak i\u00e7in genleri \u00e7a\u011f\u0131rabilir. <\/span>PARP inhibit\u00f6rleri, kanser h\u00fccrelerinde onar\u0131m s\u00fcrecini durdurmak ve hasarl\u0131 h\u00fccrelerin \u00f6lmesine izin vermek i\u00e7in tasarlanm\u0131\u015ft\u0131r. <\/span>Yumurtal\u0131k kanserini tedavi etmek i\u00e7in kullan\u0131lan yayg\u0131n PARP inhibit\u00f6rleri, Aral\u0131k 2014’te FDA onay\u0131 alan olaparib (Lynparza\u00ae) ve FDA taraf\u0131ndan 2016’da onaylanan rucaparib’dir (Rubraca\u00ae).<\/span><\/span><\/p>\n

Proteazom inhibit\u00f6rleri:<\/span><\/span><\/strong> Bu ila\u00e7lar, kanser h\u00fccrelerinin eski proteinleri yenilerine d\u00f6n\u00fc\u015ft\u00fcrmesini ve h\u00fccreye zarar verebilecek proteinlerde toksik bir art\u0131\u015fa neden olmas\u0131n\u0131 \u00f6nlemek i\u00e7in tasarlanm\u0131\u015ft\u0131r. <\/span>Proteazomlar, h\u00fccreler i\u00e7inde proteinleri par\u00e7alayarak geri d\u00f6n\u00fc\u015ft\u00fcr\u00fclebilmeleri i\u00e7in t\u00fcp benzeri yap\u0131lard\u0131r. <\/span>Kanser h\u00fccreleri, di\u011fer h\u00fccrelerden daha fazla proteazomlara g\u00fcvenebilir, \u00e7\u00fcnk\u00fc kontrols\u00fcz b\u00fcy\u00fcmeleri s\u0131kl\u0131kla proteinin a\u015f\u0131r\u0131 \u00fcretimine yol a\u00e7ar. <\/span>Proteazom inhibit\u00f6rlerinin ayr\u0131ca, apoptoz ad\u0131 verilen sa\u011fl\u0131kl\u0131 h\u00fccrelerde normal bir s\u00fcre\u00e7 olan h\u00fccre \u00f6l\u00fcm\u00fcn\u00fc destekleyen protein seviyelerini artt\u0131rd\u0131\u011f\u0131 d\u00fc\u015f\u00fcn\u00fclmektedir. <\/span>Albrootozum ortak inhibit\u00f6r\u00fc , <\/span>multipl miyelomun tedavisi i\u00e7in onaylanm\u0131\u015ft\u0131r, bortezomib’dir (Vilkad <\/span><\/span>\u00ae<\/span><\/span><\/sup> ).<\/span><\/span><\/p>\n

Anjiyogenez inhibit\u00f6rleri:<\/span><\/span><\/strong> Bu ila\u00e7lar, kanser h\u00fccrelerinin yeni bir kan kayna\u011f\u0131 geli\u015ftirmesini \u00f6nlemek i\u00e7in kullan\u0131labilir. <\/span>Anjiyogenez, h\u00fccrelerin yeni kan damarlar\u0131 olu\u015fturma s\u00fcrecidir. <\/span>T\u00fcm\u00f6rler belirli bir boyuta ula\u015ft\u0131\u011f\u0131nda, v\u00fccudun damar sistemine ula\u015fmak i\u00e7in b\u00fcy\u00fcme fakt\u00f6r\u00fc resept\u00f6rleri ad\u0131 verilen proteinleri kullan\u0131rlar ve t\u00fcm\u00f6r b\u00fcy\u00fcmesine yard\u0131mc\u0131 olabilecek sabit bir kan ak\u0131\u015f\u0131 olu\u015ftururlar. <\/span>Anjiyogenez inhibit\u00f6rleri, b\u00fcy\u00fcme fakt\u00f6r\u00fc proteinlerini arar ve bunlar\u0131n \u00e7al\u0131\u015fmas\u0131n\u0131 engelleyerek t\u00fcm\u00f6r\u00fcn besin kayna\u011f\u0131n\u0131 keser. <\/span>Kanseri tedavi etmek i\u00e7in yayg\u0131n olarak kullan\u0131lan anjiyogenez inhibit\u00f6rleri, bir\u00e7ok kanseri tedavi etmek i\u00e7in kullan\u0131labilen bevacizumab (Avastin\u00ae) ve kolorektal kanseri tedavi etmek i\u00e7in kullan\u0131labilen setuksimab’d\u0131r (Erbitux\u00ae).<\/span><\/span><\/p>\n

Tirozin kinaz inhibit\u00f6rleri:<\/span><\/span><\/strong> Bu blok sinyalleri, h\u00fccrenin b\u00fcy\u00fcmesine veya \u00e7o\u011falmas\u0131na neden olabilecek h\u00fccre \u00e7ekirde\u011fine g\u00f6nderilir. <\/span>Tirozin kinazlar kanser h\u00fccrelerinde s\u0131kl\u0131kla a\u015f\u0131r\u0131 aktiftir ve sinyal molek\u00fcl\u00fc taraf\u0131ndan aktive edildi\u011finde kontrols\u00fcz b\u00fcy\u00fcmeye veya h\u00fccre b\u00f6l\u00fcnmesine yol a\u00e7abilirler. <\/span>Tirozin kinaz inhibit\u00f6rleri bu enzimleri bloke eder ve t\u00fcm\u00f6r b\u00fcy\u00fcmesini durdurabilir veya yava\u015flatabilir. <\/span>Kanseri tedavi etmek i\u00e7in yayg\u0131n olarak kullan\u0131lan tirozin kinaz inhibit\u00f6rleri, l\u00f6semiyi tedavi etmek i\u00e7in kullan\u0131labilen imatinib (Gleevec\u00ae) ve h\u00fccre h\u00fccreli akci\u011fer kanserini tedavi etmek i\u00e7in kullan\u0131labilen krizotinibdir (Xalkori\u00ae).<\/span><\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Kanser, ihtiya\u00e7lar\u0131 i\u00e7in normal h\u00fccreleri nas\u0131l kullan\u0131r? Kurnaz kanser h\u00fccreleri, geli\u015fmek ve hayatta kalmak s\u00f6z konusu oldu\u011funda genellikle neyin i\u015fe yaray\u0131p neyin yaramad\u0131\u011f\u0131n\u0131 bilir. D\u00fczensiz h\u00fccreler b\u00f6l\u00fcnmek, b\u00fcy\u00fcmek ve bazen uzak organlara seyahat etmek i\u00e7in normal h\u00fccresel davran\u0131\u015f kurallar\u0131n\u0131 \u00e7i\u011fnerken, sa\u011fl\u0131kl\u0131 h\u00fccrelerin hain g\u00fcndemlerini ilerletmek i\u00e7in kulland\u0131klar\u0131 baz\u0131 normal i\u015flevleri de benimserler. Philadelphia’daki Hastanemizde cerrahi …<\/p>\n","protected":false},"author":1,"featured_media":17705,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-18651","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-tr"],"yoast_head":"\nKanser, ihtiya\u00e7lar\u0131 i\u00e7in normal h\u00fccreleri nas\u0131l kullan\u0131r? - zdmaa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zdmaa.com\/tr\/how-cancer-uses-normal-cells-for-its-needs\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Kanser, ihtiya\u00e7lar\u0131 i\u00e7in normal h\u00fccreleri nas\u0131l kullan\u0131r? - zdmaa\" \/>\n<meta property=\"og:description\" content=\"Kanser, ihtiya\u00e7lar\u0131 i\u00e7in normal h\u00fccreleri nas\u0131l kullan\u0131r? Kurnaz kanser h\u00fccreleri, geli\u015fmek ve hayatta kalmak s\u00f6z konusu oldu\u011funda genellikle neyin i\u015fe yaray\u0131p neyin yaramad\u0131\u011f\u0131n\u0131 bilir. D\u00fczensiz h\u00fccreler b\u00f6l\u00fcnmek, b\u00fcy\u00fcmek ve bazen uzak organlara seyahat etmek i\u00e7in normal h\u00fccresel davran\u0131\u015f kurallar\u0131n\u0131 \u00e7i\u011fnerken, sa\u011fl\u0131kl\u0131 h\u00fccrelerin hain g\u00fcndemlerini ilerletmek i\u00e7in kulland\u0131klar\u0131 baz\u0131 normal i\u015flevleri de benimserler. 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