{"id":19476,"date":"2022-01-07T16:01:51","date_gmt":"2022-01-07T13:01:51","guid":{"rendered":"https:\/\/zdmaa.com\/why-does-immunotherapy-work-for-some-but-not-others\/"},"modified":"2022-01-07T23:47:01","modified_gmt":"2022-01-07T20:47:01","slug":"why-does-immunotherapy-work-for-some-but-not-others","status":"publish","type":"post","link":"https:\/\/zdmaa.com\/tr\/why-does-immunotherapy-work-for-some-but-not-others\/","title":{"rendered":"\u0130mm\u00fcnoterapi neden baz\u0131lar\u0131nda i\u015fe yararken baz\u0131lar\u0131nda i\u015fe yaramaz?"},"content":{"rendered":"

\u0130mm\u00fcnoterapi neden baz\u0131lar\u0131nda i\u015fe yararken baz\u0131lar\u0131nda i\u015fe yaramaz?<\/span><\/span><\/span><\/span><\/p>\n

\n

Bir imm\u00fcnoterapi ilac\u0131 kanser kap\u0131s\u0131n\u0131 \u00e7ald\u0131\u011f\u0131nda ve yan\u0131t gelmedi\u011finde, doktorlar ve ara\u015ft\u0131rmac\u0131lar nedeni her zaman bilemeyebilir. <\/span>Hastan\u0131n ba\u011f\u0131\u015f\u0131kl\u0131k sistemi yan\u0131t vermiyor mu? <\/span>Yoksa Yenge\u00e7 \u0131\u015f\u0131klar\u0131 kapat\u0131p evde kimse yokmu\u015f gibi mi davrand\u0131? <\/span>Amerika Kanser Tedavi Merkezlerinde t\u0131bbi onkoloji b\u00f6l\u00fcm\u00fcn\u00fcn direkt\u00f6r\u00fc Dr. Pamela Creely, “\u015eu anda herkes bu ila\u00e7lara yan\u0131t vermiyor” diyor. <\/span><\/span>\u00ae<\/span><\/span><\/sup> (CTCA) ve CTCA <\/span><\/span>\u00ae<\/span><\/span><\/sup> Philadelphia’da <\/span>bir onkolog <\/span>\u201cBunun neden oldu\u011funu ve yan\u0131t oran\u0131n\u0131 art\u0131rmak i\u00e7in neler yap\u0131labilece\u011fini anlamak i\u00e7in devam eden ara\u015ft\u0131rmalar var.\u201d<\/span><\/span><\/p>\n

Kontrol noktas\u0131 inhibit\u00f6rleri olarak bilinen imm\u00fcnoterapi ila\u00e7lar\u0131 bir sansasyon olmaya devam ediyor ve bunun iyi bir nedeni var. <\/span>Ipilimumab (Yervoy <\/span>\u00ae)<\/span><\/sup> t\u00fcr\u00fcn\u00fcn ilk ilac\u0131 oldu\u011fu 2010 y\u0131l\u0131ndan bu yana<\/span><\/span> ),<\/span> ilerlemi\u015f cilt kanseri tedavisi i\u00e7in onayland\u0131\u011f\u0131ndan, bir\u00e7ok hastada, baz\u0131lar\u0131 \u00e7ok <\/span>az \u00f6nemli yan etki ile olumlu sonu\u00e7lar g\u00f6rd\u00fc. <\/span>Bu ila\u00e7lar, kanser h\u00fccrelerini tespit ederek ve onlara sald\u0131rmak i\u00e7in ba\u011f\u0131\u015f\u0131kl\u0131k sistemine maruz b\u0131rakarak \u00e7al\u0131\u015f\u0131r. <\/span>\u015eimdi, kanser ara\u015ft\u0131rmac\u0131lar\u0131 ve klinisyenler, baz\u0131 durumlarda bir hastan\u0131n ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin neden neredeyse yan\u0131t vermedi\u011finin gizemini \u00e7\u00f6zmeye \u00e7al\u0131\u015f\u0131yorlar.<\/span><\/span><\/p>\n

T h\u00fccresi t\u00fckenmesi<\/span><\/span><\/h2>\n

Klinik direkt\u00f6r Dr. Glenn Weiss, imm\u00fcnoterapi ila\u00e7lar\u0131na \u00e7ok az tepki veren veya hi\u00e7 tepki vermeyen baz\u0131 hastalarda, “yeterli T h\u00fccrelerinin bulunmad\u0131\u011f\u0131 veya bir yan\u0131t ortaya \u00e7\u0131karmak i\u00e7in \u00e7al\u0131\u015ft\u0131\u011f\u0131 bir senaryo” olan T h\u00fccre t\u00fckenmesi ya\u015fayabilir. <\/span>Phoenix Hastanemizde bulun. <\/span>“Zaten me\u015fgul olabilirler veya do\u011fru yerde olmayabilirler ya da ba\u015fka bir \u015fey yan\u0131t vermelerini engelliyor.” <\/span>Ara\u015ft\u0131rmac\u0131lar, s\u00f6zde “maliyet ind\u00fckleyicilerin”, bir ba\u011f\u0131\u015f\u0131kl\u0131k tepkisi ba\u015flatacak kadar diren\u00e7li ve bol hale getirmek i\u00e7in T h\u00fccrelerinin \u00fcretimini nas\u0131l art\u0131rabilece\u011fini ara\u015ft\u0131r\u0131yorlar.<\/span><\/span><\/p>\n

Bu arada, Londra’daki ara\u015ft\u0131rmac\u0131lar, yeni antijenlerin imm\u00fcnoterapinin i\u015fini yapmas\u0131n\u0131 \u00f6nlemede oynayabilece\u011fi rol\u00fc ara\u015ft\u0131r\u0131yorlar. <\/span>Bir antijen, bir h\u00fccrede ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccrelerini \u00e7eken bir molek\u00fcld\u00fcr. <\/span>Neoantijenler, kanser h\u00fccreleri \u00fczerinde geli\u015fen yeni antijenlerdir. <\/span>Ara\u015ft\u0131rmac\u0131lar, baz\u0131 durumlarda kanser h\u00fccrelerinin, bir imm\u00fcnoterapi ilac\u0131na maruz kald\u0131ktan sonra bile, t\u00fcm\u00f6re sald\u0131rmak i\u00e7in T h\u00fccrelerini \u00e7a\u011f\u0131rmak i\u00e7in yeterli yeni antijen \u00fcretmedi\u011fini buldular. <\/span>Londra’daki Francis Crick Enstit\u00fcs\u00fc’nden kanser genetik\u00e7isi Dr Charles Swanton, “\u0130mm\u00fcnoterapi ila\u00e7lar\u0131na en iyi yan\u0131t verece\u011fini d\u00fc\u015f\u00fcnd\u00fc\u011f\u00fcm\u00fcz t\u00fcm\u00f6rlerin belirli bir miktarda yeni antijenleri var, ancak bu yeni antijenler neredeyse t\u00fcm kanser h\u00fccrelerinde olmal\u0131” dedi. . <\/span><\/span>\u0130statistik <\/span><\/span><\/em>Haberleri<\/span><\/span><\/em> .<\/span><\/span><\/p>\n

Yan\u0131ttan sonra n\u00fcksetmeyi anlama<\/span><\/span><\/h2>\n

Ara\u015ft\u0131rmac\u0131lar ayr\u0131ca baz\u0131 hastalar\u0131n imm\u00fcnoterapiye ilk yan\u0131ttan sonra neden n\u00fcksetti\u011fini belirlemeye \u00e7al\u0131\u015f\u0131yorlar. <\/span>Ayr\u0131 \u00e7al\u0131\u015fmalarda, ara\u015ft\u0131rmac\u0131lar, imm\u00fcnoterapi ila\u00e7lar\u0131na diren\u00e7 geli\u015ftiren kanserlerde spesifik gen mutasyonlar\u0131 ke\u015ffettiler. <\/span>\u00d6rne\u011fin MD Anderson’daki bilim adamlar\u0131, belirli mutasyonlar\u0131n ipilimumab’a (CTLA-4 kontrol noktas\u0131 inhibit\u00f6r\u00fc) kar\u015f\u0131 diren\u00e7 geli\u015ftirdi\u011fi sonucuna vard\u0131. <\/span>California \u00dcniversitesi ara\u015ft\u0131rmac\u0131lar\u0131, JAK1 ve JAK2 proteinlerinin pembrolizumab’a (Keytruda olarak sat\u0131lan bir PD-1 kontrol noktas\u0131 inhibit\u00f6r\u00fc) diren\u00e7li oldu\u011fu sonucuna vard\u0131. <\/span><\/span>\u00ae<\/span><\/span><\/sup> ) ilaca erken tepki verdikten sonra n\u00fcksetmi\u015f hastalarda. <\/span>Her iki \u00e7al\u0131\u015fmada da ara\u015ft\u0131rmac\u0131lar, kanserli mutasyonlar\u0131n, ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin kritik bir i\u015flevi olan interferon-gama sinyal yolunu bozdu\u011fu sonucuna vard\u0131. <\/span>\u0130nterferon gama (IFN- <\/span><\/span>p<\/span><\/span><\/em>), yaln\u0131zca kanser h\u00fccrelerine do\u011frudan sald\u0131rmakla kalmayan, ayn\u0131 zamanda ba\u011f\u0131\u015f\u0131kl\u0131k tepkisini y\u00f6nlendirmeye yard\u0131mc\u0131 olan haberci molek\u00fcller olarak hareket eden kanserle sava\u015fan sitokinlerdir. <\/span>Ulusal Kanser Enstit\u00fcs\u00fc (NCI) Kanser Ara\u015ft\u0131rma Merkezi’nden Dr. James Jolly, UCLA \u00e7al\u0131\u015fmas\u0131 hakk\u0131nda Ulusal Kanser Enstit\u00fcs\u00fc blog yaz\u0131s\u0131nda, “Bu, kontrol noktas\u0131 inhibit\u00f6rlerine kar\u015f\u0131 direncin nas\u0131l \u00fcstesinden gelinece\u011fine dair bulmacan\u0131n ek bir par\u00e7as\u0131” diyor.<\/span><\/span><\/p>\n

Dr. Weiss, n\u00fckslerin ve kontrol noktas\u0131 inhibit\u00f6rlerine direncin beklenmedik veya imm\u00fcnoterapilere \u00f6zg\u00fc olmad\u0131\u011f\u0131n\u0131 s\u00f6yl\u00fcyor. <\/span>\u201cAyr\u0131ca hedefe y\u00f6nelik tedavilerle de g\u00f6rebilirsiniz\u201d diyor. <\/span>“Belirli bir s\u00fcre i\u00e7inde yan\u0131t veren hasta bir kanseriniz olabilir ve sonunda kanser bir t\u00fcr diren\u00e7 geli\u015ftirir.” <\/span>Klinik deneyler yoluyla ara\u015ft\u0131rmac\u0131lar, daha iyi yan\u0131tlara kap\u0131 a\u00e7aca\u011f\u0131n\u0131 umduklar\u0131 yeni imm\u00fcnoterapi ila\u00e7lar\u0131 ve ila\u00e7 kombinasyonlar\u0131n\u0131 ke\u015ffediyorlar.<\/span><\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u0130mm\u00fcnoterapi neden baz\u0131lar\u0131nda i\u015fe yararken baz\u0131lar\u0131nda i\u015fe yaramaz? Bir imm\u00fcnoterapi ilac\u0131 kanser kap\u0131s\u0131n\u0131 \u00e7ald\u0131\u011f\u0131nda ve yan\u0131t gelmedi\u011finde, doktorlar ve ara\u015ft\u0131rmac\u0131lar nedeni her zaman bilemeyebilir. Hastan\u0131n ba\u011f\u0131\u015f\u0131kl\u0131k sistemi yan\u0131t vermiyor mu? Yoksa Yenge\u00e7 \u0131\u015f\u0131klar\u0131 kapat\u0131p evde kimse yokmu\u015f gibi mi davrand\u0131? Amerika Kanser Tedavi Merkezlerinde t\u0131bbi onkoloji b\u00f6l\u00fcm\u00fcn\u00fcn direkt\u00f6r\u00fc Dr. Pamela Creely, “\u015eu anda herkes bu …<\/p>\n","protected":false},"author":1,"featured_media":18951,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-19476","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-tr"],"yoast_head":"\n\u0130mm\u00fcnoterapi neden baz\u0131lar\u0131nda i\u015fe yararken baz\u0131lar\u0131nda i\u015fe yaramaz? - zdmaa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zdmaa.com\/tr\/why-does-immunotherapy-work-for-some-but-not-others\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u0130mm\u00fcnoterapi neden baz\u0131lar\u0131nda i\u015fe yararken baz\u0131lar\u0131nda i\u015fe yaramaz? - zdmaa\" \/>\n<meta property=\"og:description\" content=\"\u0130mm\u00fcnoterapi neden baz\u0131lar\u0131nda i\u015fe yararken baz\u0131lar\u0131nda i\u015fe yaramaz? Bir imm\u00fcnoterapi ilac\u0131 kanser kap\u0131s\u0131n\u0131 \u00e7ald\u0131\u011f\u0131nda ve yan\u0131t gelmedi\u011finde, doktorlar ve ara\u015ft\u0131rmac\u0131lar nedeni her zaman bilemeyebilir. Hastan\u0131n ba\u011f\u0131\u015f\u0131kl\u0131k sistemi yan\u0131t vermiyor mu? Yoksa Yenge\u00e7 \u0131\u015f\u0131klar\u0131 kapat\u0131p evde kimse yokmu\u015f gibi mi davrand\u0131? 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Bir imm\u00fcnoterapi ilac\u0131 kanser kap\u0131s\u0131n\u0131 \u00e7ald\u0131\u011f\u0131nda ve yan\u0131t gelmedi\u011finde, doktorlar ve ara\u015ft\u0131rmac\u0131lar nedeni her zaman bilemeyebilir. Hastan\u0131n ba\u011f\u0131\u015f\u0131kl\u0131k sistemi yan\u0131t vermiyor mu? Yoksa Yenge\u00e7 \u0131\u015f\u0131klar\u0131 kapat\u0131p evde kimse yokmu\u015f gibi mi davrand\u0131? 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