{"id":20515,"date":"2022-01-10T02:39:22","date_gmt":"2022-01-09T23:39:22","guid":{"rendered":"https:\/\/zdmaa.com\/common-medicines-to-avoid-while-undergoing-oral-chemo\/"},"modified":"2022-01-10T15:17:40","modified_gmt":"2022-01-10T12:17:40","slug":"common-medicines-to-avoid-while-undergoing-oral-chemo","status":"publish","type":"post","link":"https:\/\/zdmaa.com\/tr\/common-medicines-to-avoid-while-undergoing-oral-chemo\/","title":{"rendered":"Oral Kemoterapi Al\u0131rken Ka\u00e7\u0131n\u0131lmas\u0131 Gereken Yayg\u0131n \u0130la\u00e7lar"},"content":{"rendered":"

Oral Kemoterapi Al\u0131rken Ka\u00e7\u0131n\u0131lmas\u0131 Gereken Yayg\u0131n \u0130la\u00e7lar<\/span><\/span><\/span><\/span><\/p>\n

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Meters,<\/span><\/span><\/span> herkese ayn\u0131 anda a\u011fr\u0131 kesici ve antihistaminik almas\u0131n\u0131n a\u015f\u0131r\u0131 uyu\u015fuklu\u011fa neden olabilece\u011fini veya Advil <\/span><\/span>\u00ae<\/span><\/span><\/sup> , pet <\/span><\/span>\u00ae<\/span><\/span><\/sup> veya Motrin <\/span>\u00ae<\/span><\/sup> gibi NSAID’leri alman\u0131n \u00f6\u011fretir.<\/span><\/span>Kan suland\u0131r\u0131c\u0131 kullan\u0131rken kanama riski artar. <\/span>Ancak t\u0131p camias\u0131ndaki ve kamuoyundaki baz\u0131 ki\u015filer, yayg\u0131n kullan\u0131lan ila\u00e7lar\u0131n baz\u0131 oral kemoterapi ila\u00e7lar\u0131n\u0131n (s\u0131v\u0131 veya hap \u015feklinde al\u0131nan) etkinli\u011fini azaltabilece\u011finin veya v\u00fccutta toksik ko\u015fullara neden olabilece\u011finin daha az fark\u0131ndad\u0131r. <\/span>Bu ciddi etkile\u015fimler genellikle s\u0131v\u0131 kemoterapi veya do\u011fum kontrol haplar\u0131, 2014’ten beri patlayan ve \u015fu anda yakla\u015f\u0131k 400 deneysel kemoterapi ilac\u0131n\u0131n y\u00fczde 25’ini olu\u015fturan bir ila\u00e7 s\u0131n\u0131f\u0131 i\u00e7erir. <\/span>Amerika Kanser Merkezlerinde ayaktan t\u0131p \u015fefi Anthony Berry, “Hassas t\u0131bb\u0131n geli\u015fiyle, gelecekteki kemoterapi ajanlar\u0131n\u0131n b\u00fcy\u00fck \u00e7o\u011funlu\u011fu oral olacak” diyor. <\/span><\/span>\u00ae<\/span><\/span><\/sup>(CTCA). <\/span>“Ge\u00e7mi\u015fte, bir hastan\u0131n intraven\u00f6z kemoterapi alabilmesi i\u00e7in hastanede olmas\u0131 gerekiyordu ve ila\u00e7 etkile\u015fimleri herkesin radar\u0131nda \u00e7ok y\u00fcksekti. Art\u0131k hastalar bu oral kemoterapi tedavilerini evde alabilirler. A\u011f\u0131zdan al\u0131nan ila\u00e7lar\u0131n g\u00fcvenli bir rejimleri olmayabilir. . , \u00f6zellikle hasta k\u0131rsal bir ortamda ya\u015f\u0131yorsa ve elektronik kay\u0131tlar\u0131 onaylamam\u0131\u015f bir sa\u011fl\u0131k kurulu\u015fu g\u00f6r\u00fcyorsa Eczac\u0131 veya aile doktoru risklerin fark\u0131nda olmayabilir.\u201d<\/span><\/span><\/p>\n

Oral kemoterapi, belirli ila\u00e7lar, do\u011fal takviyeler veya g\u0131dalar dahil olmak \u00fczere bir dizi \u015feyle birle\u015ftirildi\u011finde ciddi etkile\u015fimler meydana gelebilir. <\/span>Bir \u00e7al\u0131\u015fma, oral kemoterapi ila\u00e7lar\u0131 alan hastalar\u0131n y\u00fczde 13’\u00fcnde etkile\u015fimlerin meydana geldi\u011fini ve bunlar\u0131n y\u00fczde 20’sinden fazlas\u0131n\u0131n \u00f6nemli olarak s\u0131n\u0131fland\u0131r\u0131ld\u0131\u011f\u0131n\u0131 buldu.<\/span><\/span><\/p>\n

“Hastalar y\u0131llarca a\u011f\u0131z kanseri tedavisi alabilirler ve korkular\u0131, doktorlar\u0131n\u0131n baz\u0131 ila\u00e7lara ba\u015flad\u0131klar\u0131n\u0131 s\u00f6ylemesini g\u00f6rmezden gelmeleri ve g\u00f6rmezden gelmeleridir. Hastalara buna devam etmelerini s\u00f6yl\u00fcyorum. Herkesin ne oldu\u011funuzu bilmesini istiyorsunuz. al\u0131yor. Re\u00e7ete yazan ki\u015filerin ortak deneyimine g\u00fcvenin. \u0130la\u00e7lar”. <\/span><\/span>\u2014 Stephen Lynch, MD – Phoenix Hastanesinde birinci basamak ve kabul doktoru<\/span><\/span><\/em><\/p><\/blockquote>\n

Dr. Perry, ila\u00e7lar\u0131n re\u00e7etelenmesinde bir etkile\u015fimi tetikleyebilecek \u00e7ok fazla fakt\u00f6r oldu\u011fundan, hata i\u00e7in bolca yer oldu\u011funu s\u00f6yl\u00fcyor. <\/span>Ba\u015flang\u0131\u00e7 \u200b\u200bolarak, t\u00fcm hastanelerde ve doktor muayenehanelerinde, di\u011fer sa\u011fl\u0131k kurulu\u015flar\u0131 taraf\u0131ndan eri\u015filebilen elektronik t\u0131bbi kay\u0131tlar olarak i\u015flev g\u00f6ren ve hastalar\u0131n ald\u0131klar\u0131 veya ald\u0131klar\u0131 ila\u00e7lar da dahil olmak \u00fczere tam t\u0131bbi ge\u00e7mi\u015flerini i\u00e7eren elektronik t\u0131bbi kay\u0131tlar\u0131 yoktur. <\/span>T\u0131p uzmanlar\u0131n\u0131 re\u00e7eteler, g\u00fcvenlik bilgileri, etkile\u015fimler ve kara kutu uyar\u0131lar\u0131 hakk\u0131nda e\u011fitmek i\u00e7in birden fazla elektronik veri taban\u0131 geli\u015ftirilmi\u015f olsa da, t\u00fcm sa\u011fl\u0131k hizmetleri tesisleri ayn\u0131 veri taban\u0131n\u0131 kullanmaz. <\/span>Birden \u00e7ok veritaban\u0131yla, etkile\u015fimlerin ciddiyeti hakk\u0131nda \u00e7eli\u015fkili g\u00f6r\u00fc\u015fler ortaya \u00e7\u0131k\u0131yor, bu da klinisyenlerin kar\u0131\u015f\u0131k mesajlar ald\u0131\u011f\u0131 anlam\u0131na geliyor.<\/span><\/span><\/p>\n

\u0130la\u00e7 etkile\u015fimleri potansiyeli, bir hastan\u0131n tedavi s\u00fcrecinde birden fazla noktada fark edilmeyebilir, diyor Dr. Perry: “Ya onkolog hastaya ba\u015fka bir ila\u00e7la etkile\u015fime giren bir ila\u00e7 verdiyse ve hasta birinci basamak doktoruna gidip etkile\u015fime girerse ne olur? Daha \u00f6nce re\u00e7ete edilen ila\u00e7la m\u0131?” Onkolog birinci basamak hekiminin kulland\u0131\u011f\u0131 veritaban\u0131nda yok mu? Ya da pratisyen hekimin elektronik veritaban\u0131 yoksa? O zaman hasta birinci basamak hekimine ve\/veya eczac\u0131ya g\u00fcvenerek tedavi hakk\u0131nda bilgi sahibi olmal\u0131d\u0131r. etkile\u015fim.”<\/span><\/span><\/p>\n

Etkile\u015fime neden olan ila\u00e7lar.<\/span><\/span><\/h2>\n

Antidepresanlar, kemoterapi hastalar\u0131nda, \u00f6zellikle meme kanseri olanlarda bir tak\u0131m rahats\u0131z edici reaksiyonlara neden olan ila\u00e7lar aras\u0131ndad\u0131r. <\/span>ABD Hastal\u0131k Kontrol ve \u00d6nleme Merkezlerine g\u00f6re, sekiz Amerikal\u0131dan biri antidepresan al\u0131yor; bu, Amerika Birle\u015fik Devletleri’nde ya\u015famlar\u0131 boyunca invaziv meme kanseri geli\u015ftirecek kad\u0131nlar\u0131n y\u00fczdesiyle ayn\u0131 y\u00fczdeye sahip. <\/span>Bu nedenle bu hem hastalar hem de doktorlar i\u00e7in \u00e7ok \u00f6nemlidir, bir\u00e7ok \u00e7al\u0131\u015fman\u0131n kad\u0131nlar\u0131n meme kanseri kemoterapisi i\u00e7in tamoksifen ald\u0131\u011f\u0131n\u0131 g\u00f6sterdi\u011fini bilir <\/span><\/span>\u00ae<\/span><\/span><\/sup>Ayn\u0131 zamanda belirli antidepresanlar\u0131 alanlar\u0131n \u00f6l\u00fcm riski (bir ara\u015ft\u0131rmaya g\u00f6re y\u00fczde 91), y\u00fcksek riskli antidepresanlar almayan tamoksifen hastalar\u0131na g\u00f6re \u00f6nemli \u00f6l\u00e7\u00fcde daha y\u00fcksektir. <\/span>Tamoksifen, belirli bir enzim (sitokrom P-450 2D6 veya CYP2D6) karaci\u011ferde metabolize edildi\u011finde \u00e7al\u0131\u015facak \u015fekilde tasarlanm\u0131\u015ft\u0131r. <\/span>En yayg\u0131n antidepresanlardan baz\u0131lar\u0131, tamoksifen aktivasyonunu \u00f6nleyerek CYP2D6’y\u0131 bloke eder. <\/span>diyor. <\/span>Lin\u00e7.<\/span><\/span><\/p>\n

“Meme kanseri aras\u0131ndaki benzerliklere bakt\u0131\u011f\u0131n\u0131zda, kad\u0131nlar\u0131n tamoksifen i\u00e7in harcad\u0131klar\u0131 s\u00fcre (\u015fu anki tavsiye 10 y\u0131ld\u0131r) ve bir noktada ba\u015fka bir doktorun antidepresan re\u00e7ete etme olas\u0131l\u0131\u011f\u0131 potansiyel olarak \u00f6nemli bir sorun” diyor. Doktor Lynch.<\/span><\/span><\/p>\n

Oral kemoterapi ile birlikte al\u0131nd\u0131\u011f\u0131nda tehlikeli etkile\u015fimlere neden olabilecek di\u011fer ila\u00e7lar \u015funlar\u0131 i\u00e7erir (ancak bunlarla s\u0131n\u0131rl\u0131 de\u011fildir):<\/span><\/span><\/p>\n

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  • Varfarin: Bu antikoag\u00fclan kemoterapi gibi ila\u00e7larla birlikte al\u0131nd\u0131\u011f\u0131nda, bunlar\u0131n kombinasyonu istenmeyen kanama veya p\u0131ht\u0131la\u015fma olas\u0131l\u0131\u011f\u0131n\u0131 art\u0131rabilir.<\/span><\/span><\/li>\n
  • Bulant\u0131 \u00f6nleyici ila\u00e7lar – Genellikle antiemetikler olarak bilinen bu ila\u00e7lar genellikle kemoterapinin yan etkilerini tedavi etmek i\u00e7in kullan\u0131l\u0131r. <\/span>\u00c7al\u0131\u015fmalar, baz\u0131 oral kemoterapi tedavileri ile birlikte alman\u0131n artan kusmaya yol a\u00e7abilece\u011fini bulmu\u015ftur.<\/span><\/span><\/li>\n
  • Antasitler: Tirozin kinaz inhibit\u00f6rleri (TKI’ler) olarak bilinen hedefe y\u00f6nelik tedavilerle birlikte al\u0131nd\u0131\u011f\u0131nda, bu kombinasyon v\u00fccudun antikanser ilac\u0131 emme yetene\u011fini etkileyebilir. <\/span>Bu yan etki \u00f6zellikle ilgilidir, \u00e7\u00fcnk\u00fc genellikle kusmaya veya di\u011fer belirgin semptomlara neden olan toksisite gibi genellikle bariz komplikasyonlar\u0131n aksine, v\u00fccudun kemoterapi ilac\u0131n\u0131 emmedeki ba\u015far\u0131s\u0131zl\u0131\u011f\u0131 \u00e7ok ge\u00e7 olana ve hasta kritik bir pencereyi ka\u00e7\u0131rana kadar belirgin olmayabilir, Dr Lynch, tedavi rejiminde diyor. <\/span>Dr. Lynch, “Hastan\u0131n bariz ve ezici bir yan etkisi olmad\u0131\u011f\u0131 i\u00e7in, biz klinisyenler olarak kanser tedavisinin etkinli\u011fini azaltarak elimizden gelenin en iyisini yapabiliriz” diyor.<\/span><\/span><\/li>\n
  • Trimetoprim ve s\u00fclfametosoksazol\u00fcn pop\u00fcler antibiyotik kombinasyonu: \u0130drar yolu enfeksiyonlar\u0131n\u0131, orta kulak enfeksiyonlar\u0131n\u0131 ve bron\u015fiti tedavi etmek i\u00e7in kullan\u0131l\u0131r.Bu antibiyotik, meme, deri, ba\u015f ve boyun kanserlerini tedavi etmek i\u00e7in yayg\u0131n olarak kullan\u0131lan bir kemoterapi ilac\u0131 olan metotreksat ile birlikte al\u0131nmamal\u0131d\u0131r. <\/span>Akci\u011ferin yan\u0131 s\u0131ra. <\/span>Baz\u0131 l\u00f6semi ve lenfoma t\u00fcrleri gibi.<\/span><\/span><\/li>\n
  • Steroid olmayan anti-inflamatuar ila\u00e7lar (Motrin, Aleve, Advil): Metotreksat ile kombinasyon, v\u00fccudun kemoterapi ilac\u0131n\u0131 at\u0131k olarak d\u0131\u015far\u0131 atma kabiliyetine m\u00fcdahale ederek ya\u015fam\u0131 tehdit eden toksisiteye neden olabilir.<\/span><\/span><\/li>\n
  • Baz\u0131 antibiyotikler, antifungaller, antiviraller, bulant\u0131 \u00f6nleyici ila\u00e7lar, g\u00fc\u00e7l\u00fc narkotik metadon ve baz\u0131 antihistaminikler: Bunlar\u0131, KML tedavisinde yayg\u0131n olarak kullan\u0131lan hedefe y\u00f6nelik kemoterapi ila\u00e7lar\u0131 dasatinib ve nilotinib ile birle\u015ftirmek, fel\u00e7ten ani \u00f6l\u00fcme neden olabilir.<\/span><\/span><\/li>\n<\/ul>\n

    Ka\u00e7\u0131n\u0131lmas\u0131 gereken takviyeler<\/span><\/span><\/h2>\n

    Atlanta hastanemizdeki do\u011fal t\u0131p ve rehabilitasyon hizmetleri direkt\u00f6r\u00fc FABNO’dan Daniel Keelman, baz\u0131 besin takviyelerinin kemoterapi ila\u00e7lar\u0131yla etkile\u015fime girerek v\u00fccutta toksisiteye yol a\u00e7t\u0131\u011f\u0131 veya kemoterapinin etkilerini azaltt\u0131\u011f\u0131n\u0131n da g\u00f6sterildi\u011fini s\u00f6yl\u00fcyor. , takviye, tedavi g\u00f6ren kanser hastalar\u0131n\u0131n ya\u015fam kalitesini iyile\u015ftirmek i\u00e7in b\u00fcy\u00fck bir potansiyele sahiptir.” <\/span>“Bu, klinik uygulamadaki deneyimin ve bu maddelerin biyokimyas\u0131 ve farmakolojisinin anla\u015f\u0131lmas\u0131n\u0131n ger\u00e7ekten \u00f6nemli hale geldi\u011fi yerdir.”<\/span><\/span><\/p>\n

    Dr. Kellman’a g\u00f6re, ginseng, ginkgo biloba ve deve dikeninin yan\u0131 s\u0131ra depresyon tedavisinde kullan\u0131lan bitkisel bir takviye olan St. John’s wort, bir\u00e7ok kemoterapi ilac\u0131yla birlikte kullan\u0131lmamal\u0131d\u0131r. <\/span>Baz\u0131 antidepresanlar gibi, bu re\u00e7etesiz sat\u0131lan takviyeler, v\u00fccudun CYP2D6 enzimini par\u00e7alama bi\u00e7imine m\u00fcdahale ederek, bir kemoterapi ilac\u0131n\u0131n \u00e7ok h\u0131zl\u0131 par\u00e7alanmas\u0131na neden olarak veya ilac\u0131n par\u00e7alanmas\u0131n\u0131 \u00f6nleyerek v\u00fccudu zehirleyerek etkinli\u011fini azalt\u0131r. a\u015fa\u011f\u0131. <\/span>alt\u0131nda. <\/span>Meyan \u00f6z\u00fc ve greyfurt suyu da karaci\u011ferde metabolize edildi\u011finden Dr. Kellman, baz\u0131 kemoterapi ila\u00e7lar\u0131 alan hastalar\u0131n bunlar\u0131 almamas\u0131 gerekti\u011fini s\u00f6yl\u00fcyor.<\/span><\/span><\/p>\n

    Kemoterapi s\u0131ras\u0131nda takviye almakla ilgili sonucu: \u201cKendinize re\u00e7ete yazmay\u0131n. <\/span>\u0130nternetten bir \u015feyler sat\u0131n almadan veya bir sa\u011fl\u0131kl\u0131 g\u0131da ma\u011fazas\u0131na gitmeden \u00f6nce neyin i\u015fe yarad\u0131\u011f\u0131 konusunda profesyonel tavsiye almaya \u00e7al\u0131\u015f\u0131n. <\/span>B\u00fct\u00fcnsel bir doktor veya fizyoterapist ile g\u00f6r\u00fc\u015fmek iyi bir fikirdir. <\/span>Ne ald\u0131\u011f\u0131n\u0131z konusunda onkolo\u011funuza kar\u015f\u0131 \u00e7ok a\u00e7\u0131k ve d\u00fcr\u00fcst olman\u0131z da \u00f6nemlidir, \u00e7\u00fcnk\u00fc hastalar genellikle onlar\u0131 azarlamaktan veya bir \u015feylerin yanl\u0131\u015f oldu\u011funu s\u00f6ylemekten endi\u015fe duyduklar\u0131 i\u00e7in onkolo\u011funa s\u00f6ylemezler. <\/span>Ama bu bir g\u00fcvenlik sorunudur. <\/span>Ancak Dr. Kellman, hastalar\u0131n “mide rahats\u0131zl\u0131\u011f\u0131n\u0131 \u00f6nleyerek kanser tedavisi deneyimini b\u00fcy\u00fck \u00f6l\u00e7\u00fcde iyile\u015ftirmesine” yard\u0131mc\u0131 olmak i\u00e7in bir dizi do\u011fal maddenin g\u00fcvenle al\u0131nabilece\u011fini s\u00f6yl\u00fcyor. <\/span>enerji seviyelerine yard\u0131mc\u0131 olur, n\u00f6ropatiyi azaltmaya yard\u0131mc\u0131 olur ve kan say\u0131mlar\u0131n\u0131 iyile\u015ftirmeye yard\u0131mc\u0131 olur.\u201d<\/span><\/span><\/p>\n

    Dr. Berry hastalara, re\u00e7etesiz sat\u0131lan takviyeler ve ila\u00e7lar da dahil olmak \u00fczere ald\u0131klar\u0131 her \u015feyin g\u00fcncel bir listesini tutmalar\u0131n\u0131 tavsiye ediyor. <\/span>“Her zaman cebinizde veya \u00e7antan\u0131zda ta\u015f\u0131y\u0131n ve g\u00fcncel tutun” diyor. <\/span>T\u00fcm doktorlar\u0131n her zaman ne ald\u0131\u011f\u0131n\u0131z\u0131 bildi\u011finden emin olun. <\/span>Sa\u011fl\u0131k uzman\u0131n\u0131z\u0131n onay\u0131 olmadan herhangi bir takviye, vitamin veya bitki almay\u0131n. <\/span>Dr. Lynch, “Sorunun k\u00f6k\u00fc ileti\u015fimdir” diyor. <\/span>Hastalar ancak doktorlar\u0131na kar\u015f\u0131 d\u00fcr\u00fcst olmad\u0131klar\u0131nda sorun ararlar, “Hastan\u0131n karar\u0131na sayg\u0131 duymak doktorun g\u00f6revidir. Bizim i\u015fimiz onlar\u0131 e\u011fitmek ama g\u00fcn\u00fcn sonunda neyin ne oldu\u011funu bilmek zorunday\u0131z. yap\u0131yor.”<\/span><\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

    Oral Kemoterapi Al\u0131rken Ka\u00e7\u0131n\u0131lmas\u0131 Gereken Yayg\u0131n \u0130la\u00e7lar Meters, herkese ayn\u0131 anda a\u011fr\u0131 kesici ve antihistaminik almas\u0131n\u0131n a\u015f\u0131r\u0131 uyu\u015fuklu\u011fa neden olabilece\u011fini veya Advil \u00ae , pet \u00ae veya Motrin \u00ae gibi NSAID’leri alman\u0131n \u00f6\u011fretir.Kan suland\u0131r\u0131c\u0131 kullan\u0131rken kanama riski artar. Ancak t\u0131p camias\u0131ndaki ve kamuoyundaki baz\u0131 ki\u015filer, yayg\u0131n kullan\u0131lan ila\u00e7lar\u0131n baz\u0131 oral kemoterapi ila\u00e7lar\u0131n\u0131n (s\u0131v\u0131 veya hap …<\/p>\n","protected":false},"author":1,"featured_media":20411,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-20515","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-tr"],"yoast_head":"\nOral Kemoterapi Al\u0131rken Ka\u00e7\u0131n\u0131lmas\u0131 Gereken Yayg\u0131n \u0130la\u00e7lar - zdmaa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zdmaa.com\/tr\/common-medicines-to-avoid-while-undergoing-oral-chemo\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Oral Kemoterapi Al\u0131rken Ka\u00e7\u0131n\u0131lmas\u0131 Gereken Yayg\u0131n \u0130la\u00e7lar - zdmaa\" \/>\n<meta property=\"og:description\" content=\"Oral Kemoterapi Al\u0131rken Ka\u00e7\u0131n\u0131lmas\u0131 Gereken Yayg\u0131n \u0130la\u00e7lar Meters, herkese ayn\u0131 anda a\u011fr\u0131 kesici ve antihistaminik almas\u0131n\u0131n a\u015f\u0131r\u0131 uyu\u015fuklu\u011fa neden olabilece\u011fini veya Advil \u00ae , pet \u00ae veya Motrin \u00ae gibi NSAID’leri alman\u0131n \u00f6\u011fretir.Kan suland\u0131r\u0131c\u0131 kullan\u0131rken kanama riski artar. 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