{"id":20580,"date":"2022-01-10T02:33:51","date_gmt":"2022-01-09T23:33:51","guid":{"rendered":"https:\/\/zdmaa.com\/inflammation-tied-to-cancer-lifestyle-changes-may-help\/"},"modified":"2022-01-10T15:36:42","modified_gmt":"2022-01-10T12:36:42","slug":"inflammation-tied-to-cancer-lifestyle-changes-may-help","status":"publish","type":"post","link":"https:\/\/zdmaa.com\/tr\/inflammation-tied-to-cancer-lifestyle-changes-may-help\/","title":{"rendered":"Kansere ba\u011fl\u0131 iltihaplanma, ya\u015fam tarz\u0131 de\u011fi\u015fiklikleri yard\u0131mc\u0131 olabilir"},"content":{"rendered":"

Kansere ba\u011fl\u0131 iltihaplanma, ya\u015fam tarz\u0131 de\u011fi\u015fiklikleri yard\u0131mc\u0131 olabilir<\/span><\/span><\/span><\/span><\/p>\n

\n

\u00a0Uzmanlar uzun s\u00fcredir inflamasyonun kanser geli\u015fiminde rol oynayabilece\u011finden \u015f\u00fcpheleniyorlar. <\/span>1863’te Alman bilim adam\u0131 ve doktor Rudolf Virchow ilk temas kuran ki\u015fiydi ve kanserin s\u0131kl\u0131kla kronik inflamasyon b\u00f6lgelerinde geli\u015fti\u011fini kaydetti. <\/span>Ancak ara\u015ft\u0131rmac\u0131lar, kronik inflamasyonu kanser ve di\u011fer ciddi sa\u011fl\u0131k durumlar\u0131 i\u00e7in \u00f6nemli bir risk fakt\u00f6r\u00fc olarak daha yeni tan\u0131mlad\u0131lar. <\/span>Bilimin bu ba\u011flant\u0131y\u0131 do\u011frulamas\u0131n\u0131n bu kadar uzun s\u00fcrmesinin sebepleri aras\u0131nda: Kronik inflamasyon, varsa bile \u00e7ok az d\u0131\u015fa d\u00f6n\u00fck semptomlara neden olur. <\/span>Enflamasyonun kendisi v\u00fccudun i\u015fini yapt\u0131\u011f\u0131n\u0131n bir i\u015faretidir.<\/span><\/span><\/p>\n

Enflamasyon kavram\u0131n\u0131 anlamak bazen zordur \u00e7\u00fcnk\u00fc sezgisel g\u00f6r\u00fcnebilir. <\/span>Birincisi, iltihaplanma, v\u00fccudun kendini iyile\u015ftirme yetene\u011fi i\u00e7in gerekli olan sa\u011fl\u0131kl\u0131 bir s\u00fcre\u00e7tir. <\/span>Bir enfeksiyonunuz veya yaralanman\u0131z oldu\u011funda, ba\u011f\u0131\u015f\u0131kl\u0131k sisteminiz enfeksiyonla sava\u015fmak veya hasarl\u0131 dokuyu onarmak i\u00e7in beyaz kan h\u00fccrelerini ve kimyasallar\u0131 serbest b\u0131rak\u0131r. <\/span>Ancak iltihaplanma devam ederse veya ba\u011f\u0131\u015f\u0131kl\u0131k sisteminiz, artrit ve di\u011fer otoimm\u00fcn hastal\u0131klar\u0131n neden oldu\u011fu gibi bir enfeksiyon veya yaralanma olmad\u0131\u011f\u0131nda iltihaplanma tepkisini tetiklerse, sa\u011fl\u0131kl\u0131 dokuya zarar verebilir. <\/span>“Kronik inflamasyona bazen ‘gizli inflamasyon’ denir \u00e7\u00fcnk\u00fc asla ge\u00e7meyen inflamasyondur. V\u00fccudunuzun bakteri ve vir\u00fcslerden kurtulmak i\u00e7in kulland\u0131\u011f\u0131 ‘iyi’ inflamasyonun tam tersidir ve hedefine ula\u015ft\u0131\u011f\u0131nda iyile\u015fir, ” diyor t\u0131p direkt\u00f6r\u00fc MD Eugene Ahn. Klinik ara\u015ft\u0131rma ve hematolog\/onkolog i\u00e7in. <\/span>Chicago Hastanesi.<\/span><\/span><\/p>\n

G\u00fcn\u00fcm\u00fczde ara\u015ft\u0131rmac\u0131lar, inflamasyonun ki\u015fisel b\u00f6l\u00fcnmesi hakk\u0131nda olduk\u00e7a geni\u015f bir anlay\u0131\u015fa sahiptir. <\/span>Bazen kronik inflamasyonun, kronik inflamasyon riskini art\u0131ran kal\u0131tsal genetik mutasyonlar gibi kontrol\u00fcm\u00fcz d\u0131\u015f\u0131ndaki fakt\u00f6rlerden kaynakland\u0131\u011f\u0131n\u0131 \u00f6\u011frendiler. <\/span>Ama ayn\u0131 zamanda de\u011fi\u015febilen ya\u015fam tarz\u0131 se\u00e7imlerinin sonucu da olabilir. <\/span>Bu \u00f6nemlidir, \u00e7\u00fcnk\u00fc s\u00f6zde ya\u015fam tarz\u0131na ba\u011fl\u0131 iltihaplanma y\u00fckseli\u015fte. <\/span>Dr. Ann, “\u0130nflamasyon ve kanser aras\u0131ndaki ba\u011flant\u0131 uzun s\u00fcredir a\u00e7\u0131kt\u0131, ancak ya\u015fam tarz\u0131na ba\u011fl\u0131 inflamasyon art\u0131\u015f\u0131 nedeniyle \u015fimdi daha net bir \u015fekilde odaklan\u0131labilir” diyor Dr.<\/span><\/span><\/p>\n

nedenler<\/span><\/span><\/h2>\n

Kronik inflamasyonun kanser geli\u015fimindeki rol\u00fc k\u00fc\u00e7\u00fck de\u011fildir. <\/span>Be\u015f kanser t\u00fcr\u00fcnden birinin iltihaplanmadan kaynakland\u0131\u011f\u0131 veya bundan etkilendi\u011fi d\u00fc\u015f\u00fcn\u00fclmektedir. <\/span>CTCA’n\u0131n t\u0131bbi direkt\u00f6r\u00fc Cynthia Lynch, bunun bir nedeni, kronik inflamasyonun DNA’ya zarar verebilece\u011fini s\u00f6yl\u00fcyor. <\/span><\/span>\u00ae<\/span><\/span><\/sup> Meme Kanseri Merkezi, Phoenix Hastanesi ve Medikal Onkolog. <\/span>Di\u011fer zamanlarda, iltihaplanma s\u00fcreci, t\u00fcm\u00f6re oksijen ve besin ta\u015f\u0131yan kan damarlar\u0131n\u0131n b\u00fcy\u00fcmesini uyaran sitokin ad\u0131 verilen molek\u00fcller \u00fcretir. <\/span>\u0130\u015flem ayr\u0131ca DNA’ya daha fazla zarar veren serbest radikaller ad\u0131 verilen molek\u00fcller de \u00fcretebilir. <\/span>Enflamasyonun bu yan etkileri, kanser b\u00fcy\u00fcmesini korumaya ve te\u015fvik etmeye yard\u0131mc\u0131 olabilir.<\/span><\/span><\/p>\n

Enflamasyonun kronik bir duruma d\u00f6n\u00fc\u015fmesinin nedeni her zaman net de\u011fildir. <\/span>Ge\u00e7meyen bir enfeksiyon, normal dokulara kar\u015f\u0131 anormal ba\u011f\u0131\u015f\u0131kl\u0131k reaksiyonlar\u0131 veya obezite gibi belirli durumlardan kaynaklanabilir. <\/span>Zamanla kronik inflamasyon DNA’ya zarar verebilir ve kalp hastal\u0131\u011f\u0131, tip 2 diyabet, fel\u00e7 ve kanser gibi hastal\u0131klara yol a\u00e7abilir. <\/span>Tulsa’daki hastanemizde ba\u015f boyun cerrah\u0131 olan Brad Mons, “\u0130ltihaba neden olan her \u015fey h\u00fccrenin DNA’s\u0131n\u0131n daha h\u0131zl\u0131 replikasyonunu sa\u011flayacakt\u0131r” diyor. <\/span>“H\u00fccreleriniz ne kadar \u00e7o\u011fal\u0131rsa, kanser geli\u015ftirme olas\u0131l\u0131\u011f\u0131n\u0131z o kadar artar.”<\/span><\/span><\/span><\/span><\/p>\n

Kansere neden olan kronik inflamasyon, bazen inflamasyonla karakterize bir hastal\u0131ktan kaynaklan\u0131r. <\/span>\u00d6rne\u011fin kolit, pankreatit ve hepatit hastal\u0131klar\u0131 s\u0131ras\u0131yla kolon, pankreas ve karaci\u011fer kanseri riskinin artmas\u0131yla ili\u015fkilidir. <\/span>Bu hastal\u0131klarda, ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccreleri, DNA’ya zarar verebilecek oksijen ve nitrojen i\u00e7eren olduk\u00e7a reaktif molek\u00fcller olu\u015fturur. <\/span>Enflamasyon ayr\u0131ca h\u00fccrelerin b\u00f6l\u00fcnmesine neden olabilir.<\/span><\/span><\/p>\n

Kronik inflamasyon, mide kanseri ile ili\u015fkili H. pylori ve karaci\u011fer kanseri ile ili\u015fkili hepatit B ve hepatit C gibi kronik enfeksiyonlardan da kaynaklanabilir. <\/span>HIV, Kaposi sarkomu, Hodgkin d\u0131\u015f\u0131 lenfoma ve invaziv rahim a\u011fz\u0131 kanseri dahil olmak \u00fczere vir\u00fcsler ve \u00e7ok nadir g\u00f6r\u00fclen kanserler ile enfeksiyon riskini art\u0131r\u0131r.<\/span><\/span><\/p>\n

Di\u011fer durumlarda, su\u00e7lular \u00e7evresel fakt\u00f6rlerdir. <\/span>\u00d6rne\u011fin asbeste maruz kalmak mezotelyoma geli\u015ftirme riskini art\u0131r\u0131r. <\/span>Asl\u0131nda, kansere neden olan bir\u00e7ok \u00e7evresel fakt\u00f6r ve risk fakt\u00f6r\u00fc, bir t\u00fcr kronik inflamasyonla ili\u015fkilidir. <\/span>Ulusal Sa\u011fl\u0131k Enstit\u00fcleri’ne g\u00f6re, kanserlerin y\u00fczde 20’ye kadar\u0131 kronik enfeksiyonla ba\u011flant\u0131l\u0131, y\u00fczde 30’u sigara ve asbest gibi solunan kirleticilerle ba\u011flant\u0131l\u0131 ve y\u00fczde 35’i obezite dahil diyet fakt\u00f6rleriyle ba\u011flant\u0131l\u0131. <\/span>“\u0130ster lupus veya romatoid artrit gibi bir otoimm\u00fcn hastal\u0131ktan, isterse asbest gibi maruz kalabilece\u011finiz bir kimyasal\u0131n tahri\u015finden olsun, \u00e7evremizdeki inflamatuar s\u00fcre\u00e7lerin miktar\u0131n\u0131 azaltabilirsek, kanser riskini azaltabiliriz” dedi. . <\/span>Mons diyor.<\/span><\/span><\/p>\n

Riski azaltmak<\/span><\/span><\/h2>\n

G\u00fcn\u00fcm\u00fczde ara\u015ft\u0131rmac\u0131lar, v\u00fccudun oksijen sens\u00f6rlerinin kronik iltihab\u0131 azaltmak i\u00e7in manip\u00fcle edilip edilemeyece\u011fini ara\u015ft\u0131r\u0131yorlar. <\/span>Bir \u00e7al\u0131\u015fma, ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccrelerini oksijensiz olduklar\u0131n\u0131 d\u00fc\u015f\u00fcnmeleri i\u00e7in kand\u0131rman\u0131n, enerjiyi korumak i\u00e7in iltihaplanma b\u00f6lgesinden \u00e7ekilmelerine neden oldu\u011funu buldu. <\/span>Ara\u015ft\u0131rmac\u0131lar \u015fimdi, aktive edildi\u011finde v\u00fccudun inflamatuar yan\u0131t\u0131n\u0131 azaltan spesifik proteinleri aktive etmek i\u00e7in ila\u00e7lar\u0131n geli\u015ftirilip geli\u015ftirilemeyece\u011fini ara\u015ft\u0131r\u0131yorlar.<\/span><\/span><\/p>\n

Aspirinin kronik inflamasyonu \u00f6nlemeye yard\u0131mc\u0131 olabilece\u011fine dair kan\u0131tlar da art\u0131yor. <\/span>Steroid olmayan bir anti-inflamatuar ila\u00e7, iltihab\u0131, a\u011fr\u0131y\u0131 ve ate\u015fi art\u0131ran kimyasallar olan prostaglandinlerin \u00fcretimini azaltarak \u00e7al\u0131\u015f\u0131r. <\/span><\/span>Amerikan Tabipler Birli\u011fi Dergisi’nde<\/span><\/span><\/em> yay\u0131nlanan 2016 tarihli bir raporda <\/span>, 135.000 hastada aspirin kullan\u0131m\u0131n\u0131 inceleyen ara\u015ft\u0131rmac\u0131lar, “Uzun s\u00fcreli aspirin kullan\u0131m\u0131n\u0131n kanser riskini biraz daha d\u00fc\u015f\u00fck, ancak genel kanser riskinde, \u00f6zellikle gastrointestinal sistemde \u00f6nemli bir azalma ile ili\u015fkili oldu\u011fu sonucuna varm\u0131\u015ft\u0131r. Aspirinin d\u00fczenli kullan\u0131m\u0131 kolorektal kanserlerin \u00f6nemli bir b\u00f6l\u00fcm\u00fcn\u00fc \u00f6nleyebilir. “Zaten Amerika Birle\u015fik Devletleri’nde on milyonlarca yeti\u015fkin kalp krizi veya fel\u00e7 riskini azaltmak i\u00e7in aspirin al\u0131yor.” “Belirli kanser t\u00fcrlerini \u00f6nlemek mant\u0131ks\u0131zd\u0131r. \u201ddiyor Dr. Ann.<\/span><\/span><\/p>\n

Amerika Birle\u015fik Devletleri \u00d6nleyici Hizmetler G\u00f6rev G\u00fcc\u00fc, \u015fimdi 50 ila 59 ya\u015flar\u0131 aras\u0131ndaki baz\u0131 yeti\u015fkinlerin kolorektal kanseri \u00f6nlemeye yard\u0131mc\u0131 olmak i\u00e7in d\u00fc\u015f\u00fck doz aspirin almas\u0131n\u0131 tavsiye ediyor ve ya\u015fl\u0131 yeti\u015fkinlerin de bir aspirin rejimini d\u00fc\u015f\u00fcnmesini \u00f6neriyor. <\/span>Dr. Lynch, “Aspirinin di\u011fer kanser t\u00fcrlerini de tedavi etti\u011fi d\u00fc\u015f\u00fcn\u00fcl\u00fcyor, ancak \u015fu anda kolorektal kanserden ba\u015fka bir \u015fey hakk\u0131nda fazla bilgi yok” diyor.<\/span><\/span><\/p>\n

Ya\u015fam tarz\u0131 de\u011fi\u015fiklikleri<\/span><\/span><\/h2>\n

Obezite, stres ve egzersiz eksikli\u011fi gibi beslenme fakt\u00f6rlerine ba\u011fl\u0131 kanserlerin y\u00fczde 35’i ile ya\u015fam tarz\u0131 al\u0131\u015fkanl\u0131klar\u0131 ve iltihaplanma aras\u0131ndaki ba\u011flant\u0131 endi\u015fe kayna\u011f\u0131 olmaya devam ediyor. <\/span>Bu fakt\u00f6rler, enfeksiyon olmasa bile dokularla sava\u015fmak veya iyile\u015ftirmek i\u00e7in bir ba\u011f\u0131\u015f\u0131kl\u0131k tepkisini tetikler. <\/span>Dr. Ann, “Enflamasyonun \u015fu anda bas\u0131nda bu kadar \u00e7ok dikkat \u00e7ekmesinin nedeni, bu kadar \u00e7ok \u015feyin ya\u015fam tarz\u0131m\u0131za ba\u011fl\u0131 olmas\u0131d\u0131r” diyor. <\/span>“Ne kadar hareketsizseniz ve diyetiniz ne kadar zay\u0131fsa, o kadar fazla iltihaplanmaya neden olursunuz.”<\/span><\/span><\/p>\n

Asl\u0131nda, Amerikan Kanser Ara\u015ft\u0131rmalar\u0131 Enstit\u00fcs\u00fc’n\u00fcn 2016 tarihli bir raporu, sa\u011fl\u0131kl\u0131 bir kiloyu koruman\u0131n, t\u00fct\u00fcn ve a\u015f\u0131r\u0131 g\u00fcne\u015fe maruz kalmaktan ka\u00e7\u0131nmak kadar \u00f6nemli olabilece\u011fini buldu. <\/span>Amerikan Kanser Derne\u011fi, besleyici bir diyet yiyerek, alkol t\u00fcketimini s\u0131n\u0131rlayarak ve di\u011fer \u00f6nemli ad\u0131mlar\u0131 atarak sa\u011fl\u0131kl\u0131 bir ya\u015fam tarz\u0131 s\u00fcrd\u00fcrenlerin kansere yakalanma olas\u0131l\u0131\u011f\u0131n\u0131n y\u00fczde 10 ila 20 daha az oldu\u011funu buldu.<\/span><\/span><\/p>\n

Dr. Lynch, diyet ve egzersizin sa\u011fl\u0131kl\u0131 ya\u015fam tarzlar\u0131 listesinin ba\u015f\u0131nda geldi\u011fini s\u00f6yl\u00fcyor. <\/span>Taba\u011f\u0131n\u0131za iltihap \u00f6nleyici bitkisel besinler i\u00e7eren daha fazla bitkisel g\u0131da eklemek ve do\u011fal iltihaplanmay\u0131 azaltan probiyotikler i\u00e7eren yo\u011furt ve miso gibi daha fazla fermente g\u0131dalar yemek gibi k\u00fc\u00e7\u00fck de\u011fi\u015fiklikler bile fark yaratabilir. <\/span>Ayr\u0131ca asbest, silika ve t\u00fct\u00fcn gibi kanserojen maddelerden uzak durmaya \u00e7al\u0131\u015f\u0131n ve hepatit B veya hepatit C gibi bir durumunuz varsa tedavi aray\u0131n.<\/span><\/span><\/span><\/span><\/p>\n

Uzmanlar ayr\u0131ca g\u0131rtlak kanseri riskini art\u0131rabilecek i\u015flenmi\u015f g\u0131dalar\u0131n s\u0131n\u0131rland\u0131r\u0131lmas\u0131n\u0131 tavsiye ediyor. <\/span>Dr. Mons, “\u00d6nemli de\u011fil, ancak risk, taze \u00fcr\u00fcnler yiyen birininkinden daha fazlad\u0131r, \u00e7\u00fcnk\u00fc bu koruyucular tahri\u015f edici olarak hareket eder” diyor. <\/span>Alkol ayr\u0131ca, \u00f6zellikle yutuldu\u011funda yiyecek veya i\u00e7eceklerin dokunuldu\u011fu b\u00f6lge olan ba\u015f ve boyun i\u00e7in tahri\u015f edici etki g\u00f6sterebilir. <\/span>Ba\u015fka bir endi\u015fe: alkol ve \u00fcr\u00fcnleri karaci\u011fere zarar verebilir ve organda iltihaplanmaya neden olabilir.<\/span><\/span><\/p>\n

Alt sat\u0131r: neyi de\u011fi\u015ftirebilece\u011finize odaklan\u0131n. <\/span>diyor. <\/span>Ah. <\/span>“\u0130\u015fte ya\u015fam tarz\u0131 burada devreye giriyor.”<\/span><\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Kansere ba\u011fl\u0131 iltihaplanma, ya\u015fam tarz\u0131 de\u011fi\u015fiklikleri yard\u0131mc\u0131 olabilir \u00a0Uzmanlar uzun s\u00fcredir inflamasyonun kanser geli\u015fiminde rol oynayabilece\u011finden \u015f\u00fcpheleniyorlar. 1863’te Alman bilim adam\u0131 ve doktor Rudolf Virchow ilk temas kuran ki\u015fiydi ve kanserin s\u0131kl\u0131kla kronik inflamasyon b\u00f6lgelerinde geli\u015fti\u011fini kaydetti. Ancak ara\u015ft\u0131rmac\u0131lar, kronik inflamasyonu kanser ve di\u011fer ciddi sa\u011fl\u0131k durumlar\u0131 i\u00e7in \u00f6nemli bir risk fakt\u00f6r\u00fc olarak daha yeni …<\/p>\n","protected":false},"author":1,"featured_media":20393,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-20580","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-tr"],"yoast_head":"\nKansere ba\u011fl\u0131 iltihaplanma, ya\u015fam tarz\u0131 de\u011fi\u015fiklikleri yard\u0131mc\u0131 olabilir - zdmaa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zdmaa.com\/tr\/inflammation-tied-to-cancer-lifestyle-changes-may-help\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Kansere ba\u011fl\u0131 iltihaplanma, ya\u015fam tarz\u0131 de\u011fi\u015fiklikleri yard\u0131mc\u0131 olabilir - zdmaa\" \/>\n<meta property=\"og:description\" content=\"Kansere ba\u011fl\u0131 iltihaplanma, ya\u015fam tarz\u0131 de\u011fi\u015fiklikleri yard\u0131mc\u0131 olabilir \u00a0Uzmanlar uzun s\u00fcredir inflamasyonun kanser geli\u015fiminde rol oynayabilece\u011finden \u015f\u00fcpheleniyorlar. 1863’te Alman bilim adam\u0131 ve doktor Rudolf Virchow ilk temas kuran ki\u015fiydi ve kanserin s\u0131kl\u0131kla kronik inflamasyon b\u00f6lgelerinde geli\u015fti\u011fini kaydetti. 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