{"id":21054,"date":"2022-01-10T00:30:49","date_gmt":"2022-01-09T21:30:49","guid":{"rendered":"https:\/\/zdmaa.com\/attacking-cancer-cells-where-they-hide\/"},"modified":"2022-01-10T23:09:49","modified_gmt":"2022-01-10T20:09:49","slug":"attacking-cancer-cells-where-they-hide","status":"publish","type":"post","link":"https:\/\/zdmaa.com\/tr\/attacking-cancer-cells-where-they-hide\/","title":{"rendered":"Sakland\u0131klar\u0131 kanser h\u00fccrelerine sald\u0131rmak"},"content":{"rendered":"

Sakland\u0131klar\u0131 kanser h\u00fccrelerine sald\u0131rmak<\/span><\/span><\/span><\/span><\/p>\n

\n

B filmindeki gangsterlerin polisten ka\u00e7mas\u0131 gibi bazen kanser h\u00fccreleri de ka\u00e7\u0131yor. <\/span>Yakalanmaktan (cerrah\u0131n b\u0131\u00e7a\u011f\u0131ndan ka\u00e7\u0131nmaktan) veya \u00f6l\u00fcmden (hayatta kalan kemoterapi ila\u00e7lar\u0131) ka\u00e7\u0131n\u0131rlar ve \u0131s\u0131 kapanana kadar molek\u00fcler topuklar\u0131n\u0131 so\u011futmak i\u00e7in saklanacak bir yer bulurlar. <\/span>Aylar ya da y\u0131llar sonra yuvalar\u0131ndan \u00e7\u0131kt\u0131klar\u0131nda bu h\u00fccreler eskisinden daha g\u00fc\u00e7l\u00fc olabilir ve orijinal kanserden daha diren\u00e7li metastaz olu\u015fturabilirler. <\/span>May\u0131s ay\u0131nda yay\u0131nlanan bir makalede Duke \u00dcniversitesi ara\u015ft\u0131rmac\u0131lar\u0131, laboratuvar farelerinde hormon pozitif meme kanseri h\u00fccrelerinin ka\u00e7mas\u0131na, kemik ili\u011fine ba\u011flanmas\u0131na ve tedaviden saklanmas\u0131na izin veren iki protein tan\u0131mlad\u0131klar\u0131n\u0131 s\u00f6yledi. <\/span>Duke’den Dr. Dorothy A. Sipkins sonu\u00e7lar\u0131 a\u00e7\u0131klarken “Art\u0131k nas\u0131l girdiklerini biliyoruz” diyor. <\/span>“Ayr\u0131ca kemik ili\u011finde sa\u011flam bir \u015fekilde yerle\u015fmelerini sa\u011flayan \u00f6nemli bir mekanizma belirledik.”<\/span><\/span><\/p>\n

Meme kanseri h\u00fccreleri yay\u0131ld\u0131\u011f\u0131nda<\/span><\/span><\/h2>\n

Meme kanseri h\u00fccrelerinin g\u00f6\u00e7ebe oldu\u011fu ve kemiklere, beyine, karaci\u011fere ve akci\u011ferlere yerle\u015fti\u011fi bilinmektedir. <\/span>Baz\u0131 durumlarda, kanser h\u00fccreleri hastaya te\u015fhis konmadan \u00f6nce birincil t\u00fcm\u00f6rden ka\u00e7abilir. <\/span>Bu h\u00fccreler, bir hasta aylarca tedavi g\u00f6rse ve ard\u0131ndan doktorlara herhangi bir kanser belirtisi bulamad\u0131klar\u0131 s\u00f6ylense bile uykuda kalabilir veya inlerinde yava\u015f b\u00fcy\u00fcyebilir. <\/span>Phoenix yak\u0131nlar\u0131ndaki hastanemizde t\u0131bbi onkolog olan Cynthia Lynch, “Bu h\u00fccreler \u00e7ok yava\u015f b\u00fcy\u00fcd\u00fc\u011f\u00fc i\u00e7in birinin metastatik hastal\u0131\u011f\u0131 oldu\u011funu anlaman\u0131z uzun zaman alabilir” diyor.<\/span><\/span><\/p>\n

Duke ara\u015ft\u0131rmac\u0131lar\u0131, bu metastatik h\u00fccrelerin baz\u0131lar\u0131n\u0131n, genellikle kemik ili\u011finde bulunan E-selektin molek\u00fcl\u00fcn\u00fc arad\u0131\u011f\u0131n\u0131 s\u00f6yl\u00fcyor. <\/span>Kanser h\u00fccreleri E-selektine ba\u011flanarak ili\u011fe girmesine izin verir. <\/span>Orada, CXCR4 ad\u0131 verilen ba\u015fka bir protein, h\u00fccrelerin y\u0131llarca saklanabilecekleri kemik ili\u011finde yuvalanmas\u0131na izin verir. <\/span>E-selektin inhibit\u00f6r\u00fc GMI-1271, metastatik h\u00fccrelerin kemik ili\u011fine girmesini \u00f6nleyebilir. <\/span>Ara\u015ft\u0131rmac\u0131lar ayr\u0131ca <\/span>multipl miyelom t\u00fcm\u00f6r\u00fc ve lenfoma lenfomas\u0131n\u0131 tedavi etmek i\u00e7in kullan\u0131labilen <\/span>ila\u00e7 Plerixafor’un (Mozobil <\/span><\/span>\u00ae<\/span><\/span><\/sup> ) CXCR4 i\u00e7in bir <\/span>engelleyici g\u00f6revi g\u00f6rebilece\u011fine ve gizli h\u00fccreleri \u00f6ld\u00fcrebilece\u011fine ve bunlar\u0131 tedavi i\u00e7in g\u00f6sterdi\u011fine inan\u0131yorlar. <\/span>Makalenin ba\u015f yazar\u0131 Dr. Sipkins, “Bu meme kanseri h\u00fccrelerinin v\u00fccutta nas\u0131l g\u00f6\u00e7 etti\u011fini ve ya\u015fam d\u00f6ng\u00fclerini anlayarak, onlar\u0131 daha savunmas\u0131z ve tedavi edilebilir hale getirmenin yollar\u0131n\u0131 ke\u015ffedebilece\u011fimizi umuyoruz” diyor. <\/span><\/span>Bilimsel \u00e7eviri t\u0131bb\u0131<\/span><\/span><\/em> .<\/span><\/span><\/p>\n

tedaviden ka\u00e7\u0131nmak<\/span><\/span><\/h2>\n

Bu gizleme ve tedaviden ka\u00e7\u0131nma yetene\u011fi , <\/span>meme hastalar\u0131n\u0131n tamoksifen (Nolvadex) Cancer <\/span><\/span>\u00ae<\/span><\/span><\/sup> ) veya hormonlar\u0131 inhibe eden bir hormon inhibit\u00f6rleri <\/span>gibi tedavilere devam <\/span>etmesini, testler v\u00fccudun art\u0131k kanser kan\u0131t\u0131 olmad\u0131\u011f\u0131n\u0131 g\u00f6sterdikten sonra bile <\/span>gerekli k\u0131lar. <\/span>diyor Dr. Lynch. <\/span>Aktif olmayan veya yava\u015f b\u00fcy\u00fcyen meme kanseri h\u00fccreleri, zor yan etkilere sahip olabilen kemoterapiye her zaman yan\u0131t vermez. <\/span>Ve hormon tedavisi on y\u0131la kadar s\u00fcrebilir. <\/span>“Yan etkileri de olan bir ilac\u0131 almak i\u00e7in uzun bir zaman” diyor.<\/span><\/span><\/p>\n

Tedavi yorgunlu\u011fu ya\u015fayan baz\u0131 hastalar da kanser tedavi rejimlerini s\u00fcrd\u00fcrmekte zorluk \u00e7ekerler. <\/span>\u201cBazen hastalar bunun, prognozlar\u0131n\u0131n o kadar iyi oldu\u011funu ve hormon tedavisi g\u00f6rmeden ondan kurtulabileceklerini d\u00fc\u015f\u00fcn\u00fcyor\u201d diyor. <\/span>“Ama g\u00f6r\u00fcyoruz ki hormon pozitif meme kanserinde, tekrarlama riskinin 5-10. y\u0131llarda oldu\u011fu gibi 1-5. y\u0131llarda da ayn\u0131 oldu\u011funu g\u00f6r\u00fcyoruz. Bunu hastalar\u0131 korkutmak i\u00e7in de\u011fil, ila\u00e7lar\u0131m\u0131z oldu\u011fu i\u00e7in s\u00f6yl\u00fcyorum. hormon \u00fcretimini azaltabilir ve etkisi, tekrarlama riskini azaltmada \u00e7ok g\u00fc\u00e7l\u00fcd\u00fcr.\u201d<\/span><\/span><\/p>\n

Daha iyi tedaviler ve \u00f6nleme stratejileri aray\u0131\u015f\u0131nda olan bilim adamlar\u0131, en zorlu ortamlarda bile kanserin nas\u0131l b\u00fcy\u00fcd\u00fc\u011f\u00fc ve hayatta kald\u0131\u011f\u0131 hakk\u0131nda daha fazla \u015fey \u00f6\u011freniyor. <\/span>Bu blog, Kanser Nas\u0131l Yapar? adl\u0131 ara s\u0131ra yay\u0131nlanan bir dizinin par\u00e7as\u0131d\u0131r. <\/span>B\u00fcy\u00fcyen anlay\u0131\u015f\u0131m\u0131za katk\u0131da bulunan, yak\u0131n zamanda ke\u015ffedilen kanserle ilgili davran\u0131\u015flar\u0131 vurgulamak i\u00e7in tasarlanm\u0131\u015ft\u0131r.<\/span><\/span><\/em><\/p>\n

Meme kanseri i\u00e7in geli\u015fmi\u015f tedaviler hakk\u0131nda daha fazla bilgi edinin.<\/span><\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Sakland\u0131klar\u0131 kanser h\u00fccrelerine sald\u0131rmak B filmindeki gangsterlerin polisten ka\u00e7mas\u0131 gibi bazen kanser h\u00fccreleri de ka\u00e7\u0131yor. Yakalanmaktan (cerrah\u0131n b\u0131\u00e7a\u011f\u0131ndan ka\u00e7\u0131nmaktan) veya \u00f6l\u00fcmden (hayatta kalan kemoterapi ila\u00e7lar\u0131) ka\u00e7\u0131n\u0131rlar ve \u0131s\u0131 kapanana kadar molek\u00fcler topuklar\u0131n\u0131 so\u011futmak i\u00e7in saklanacak bir yer bulurlar. Aylar ya da y\u0131llar sonra yuvalar\u0131ndan \u00e7\u0131kt\u0131klar\u0131nda bu h\u00fccreler eskisinden daha g\u00fc\u00e7l\u00fc olabilir ve orijinal kanserden daha …<\/p>\n","protected":false},"author":1,"featured_media":20150,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-21054","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-tr"],"yoast_head":"\nSakland\u0131klar\u0131 kanser h\u00fccrelerine sald\u0131rmak - zdmaa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zdmaa.com\/tr\/attacking-cancer-cells-where-they-hide\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sakland\u0131klar\u0131 kanser h\u00fccrelerine sald\u0131rmak - zdmaa\" \/>\n<meta property=\"og:description\" content=\"Sakland\u0131klar\u0131 kanser h\u00fccrelerine sald\u0131rmak B filmindeki gangsterlerin polisten ka\u00e7mas\u0131 gibi bazen kanser h\u00fccreleri de ka\u00e7\u0131yor. Yakalanmaktan (cerrah\u0131n b\u0131\u00e7a\u011f\u0131ndan ka\u00e7\u0131nmaktan) veya \u00f6l\u00fcmden (hayatta kalan kemoterapi ila\u00e7lar\u0131) ka\u00e7\u0131n\u0131rlar ve \u0131s\u0131 kapanana kadar molek\u00fcler topuklar\u0131n\u0131 so\u011futmak i\u00e7in saklanacak bir yer bulurlar. 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