{"id":21349,"date":"2022-01-09T23:27:40","date_gmt":"2022-01-09T20:27:40","guid":{"rendered":"https:\/\/zdmaa.com\/positive-news-in-triple-negative-breast-cancer-research\/"},"modified":"2022-01-11T01:25:18","modified_gmt":"2022-01-10T22:25:18","slug":"positive-news-in-triple-negative-breast-cancer-research","status":"publish","type":"post","link":"https:\/\/zdmaa.com\/tr\/positive-news-in-triple-negative-breast-cancer-research\/","title":{"rendered":"\u00dc\u00e7l\u00fc negatif meme kanseri ara\u015ft\u0131rmas\u0131nda olumlu haberler"},"content":{"rendered":"

\u00dc\u00e7l\u00fc negatif meme kanseri ara\u015ft\u0131rmas\u0131nda olumlu haberler<\/span><\/span><\/span><\/span><\/p>\n

\n

Scripps Ara\u015ft\u0131rma Enstit\u00fcs\u00fc’ndeki ara\u015ft\u0131rmac\u0131lar taraf\u0131ndan yak\u0131n zamanda yap\u0131lan bir ara\u015ft\u0131rma, tedavisi en zor kanser t\u00fcrlerinden biri olan \u00fc\u00e7l\u00fc negatif meme kanserinin tedavisine \u0131\u015f\u0131k tutuyor. <\/span>Ara\u015ft\u0131rma, gen ekspresyonunu ve protein geli\u015fimini d\u00fczenlemeye yard\u0131mc\u0131 olan mikroRNA’lar ad\u0131 verilen molek\u00fcllere odakland\u0131. <\/span>Bilim adamlar\u0131, baz\u0131 \u00e7al\u0131\u015fmalarda birden fazla kanser t\u00fcr\u00fc ve di\u011fer hastal\u0131klarla ba\u011flant\u0131l\u0131 olan zahmetli bir molek\u00fcl olan microRNA-96 ile \u00f6zellikle ilgilendiler.<\/span><\/span><\/p>\n

Scripps’in ara\u015ft\u0131rmas\u0131, meme kanseri h\u00fccrelerinde mikroRNA-96’y\u0131 hedefleyen ve hasarl\u0131 veya mutasyona u\u011fram\u0131\u015f h\u00fccrelerin kapat\u0131ld\u0131\u011f\u0131 bir s\u00fcre\u00e7 olan apoptoza yol a\u00e7an targaprimir-96 adl\u0131 bir bile\u015fik kulland\u0131. <\/span>Laboratuar hayvanlar\u0131nda 21 g\u00fcnl\u00fck bir \u00e7al\u0131\u015fman\u0131n ard\u0131ndan ara\u015ft\u0131rmac\u0131lar, bile\u015fi\u011fin, k\u00f6t\u00fc h\u00fccreleri kendilerini \u00f6ld\u00fcrmeye te\u015fvik eden ve t\u00fcm\u00f6r b\u00fcy\u00fcmesini yava\u015flatan mikroRNA-96 \u00fcretimini azaltt\u0131\u011f\u0131 sonucuna vard\u0131lar. <\/span>Ara\u015ft\u0131rmac\u0131lar, normal h\u00fccrelerin bile\u015fik taraf\u0131ndan zarar g\u00f6rmedi\u011fini s\u00f6yledi. <\/span>Scripps ara\u015ft\u0131rmac\u0131s\u0131 Matthew Disney yapt\u0131\u011f\u0131 a\u00e7\u0131klamada, “\u00c7al\u0131\u015fma, hassas t\u0131pta a\u00e7\u0131k bir ilerlemeyi temsil ediyor, \u00e7\u00fcnk\u00fc bu molek\u00fcl, sa\u011fl\u0131kl\u0131 h\u00fccreleri de\u011fil, yaln\u0131zca kansere neden olan geni ifade eden kanser h\u00fccrelerini \u00f6ld\u00fcr\u00fcyor.” Dedi.<\/span><\/span><\/p>\n

\u0130lgili meme kanseri formlar\u0131.<\/span><\/span><\/h2>\n

\u00c7o\u011fu meme kanseri \u00f6strojen resept\u00f6r\u00fc pozitif (ER pozitif), progesteron resept\u00f6r\u00fc pozitif (PR pozitif) veya insan epidermal b\u00fcy\u00fcme fakt\u00f6r\u00fc resept\u00f6r\u00fc 2 (HER2 pozitif) genini ifade eder. <\/span>Meme kanseri pozitif HER2 tedavisi i\u00e7in <\/span>monoklonal Trastuzumab (Herceptin) <\/span><\/span>\u00ae<\/span><\/span><\/sup> ) <\/span>antikor tedavisi, meme t\u00fcm malign t\u00fcm\u00f6rlerin yakla\u015f\u0131k \u00fc\u00e7te ikisini temsil eden, hormon tedavisi, genellikle pozitif ER ve pozitif PR meme kanserleri tedavi edilir <\/span>. <\/span>Bu tedaviler genellikle kemoterapi ve\/veya meme kanseri cerrahisi gibi di\u011fer tedavilerle birle\u015ftirilir.<\/span><\/span><\/p>\n

\u00dc\u00e7l\u00fc negatif meme kanseri, ad\u0131n\u0131 ER, PR ve HER2 meme kanseri belirte\u00e7lerinin yoklu\u011fundan al\u0131r. <\/span>Genellikle kemoterapi, cerrahi ve\/veya radyoterapi kombinasyonu ile tedavi edilir. <\/span>Ancak bu belirte\u00e7ler olmadan, onkologlar\u0131n daha kesin bir tedavi rejiminin par\u00e7as\u0131 olarak hedef alacak belirli bir hormonu veya geni yoktur, bu da kanser t\u00fcr\u00fcn\u00fc tedavi etmeyi zorla\u015ft\u0131r\u0131r. <\/span>\u00dc\u00e7l\u00fc negatif meme kanseri, 50 ya\u015f\u0131n alt\u0131ndaki kad\u0131nlarda ve BRCA1 gen mutasyonunu kal\u0131tsal olarak ta\u015f\u0131yan bir\u00e7ok kad\u0131nda daha yayg\u0131nd\u0131r. <\/span>Ayr\u0131ca Afrikal\u0131 Amerikal\u0131 kad\u0131nlar aras\u0131nda beyaz veya Asyal\u0131 kad\u0131nlardan daha yayg\u0131nd\u0131r.<\/span><\/span><\/p>\n

Atlanta yak\u0131nlar\u0131ndaki hastanemizde kanser ara\u015ft\u0131rmalar\u0131 direkt\u00f6r\u00fc ve bir meme onkolo\u011fu olan MD, MSc Ricardo Alvarez diyor. <\/span>“Tek tip bir hastal\u0131k olmad\u0131\u011f\u0131n\u0131 \u00f6\u011frendik. En az sekiz farkl\u0131 hastal\u0131k var ve baz\u0131 durumlarda \u00e7ok ilgin\u00e7 yan\u0131tlar\u0131 olabiliyor. Yani \u015fu anda alt tiplerini belirlemeye \u00e7al\u0131\u015fan bir\u00e7ok klinik \u00e7al\u0131\u015fma var. Baz\u0131 ila\u00e7lar i\u00e7in meme kanserine kimlerin olumsuz yan\u0131t verece\u011fi.<\/span><\/span><\/p>\n

MicroRNA-96, d\u00fcnyadaki hastal\u0131k ara\u015ft\u0131rmac\u0131lar\u0131n\u0131n radar\u0131nda. <\/span>Programlanm\u0131\u015f h\u00fccre \u00f6l\u00fcm\u00fcn\u00fc engelledi\u011fi i\u00e7in kanser h\u00fccreleri de dahil olmak \u00fczere k\u00f6t\u00fc h\u00fccrelerin b\u00fcy\u00fcmesine ve \u00e7o\u011falmas\u0131na izin verebilir. <\/span>Japonya’daki bilim adamlar\u0131, molek\u00fcl\u00fcn pankreas kanserindeki rol\u00fcn\u00fc ara\u015ft\u0131r\u0131yorlar. <\/span>\u00c7in’deki ara\u015ft\u0131rmac\u0131lar, mikroRNA-96’y\u0131 karma\u015f\u0131k bir beyin kanseri formu olan glioblastoma multiforme’ye ba\u011flad\u0131lar. <\/span>Scripps bilim adamlar\u0131, mikroRNA’lar \u00fczerindeki erken ara\u015ft\u0131rmalar\u0131n\u0131n kanser i\u00e7in yeni tedavilere ve di\u011fer hastal\u0131klara da sald\u0131rma stratejilerine yol a\u00e7aca\u011f\u0131n\u0131 umuyor. <\/span>Scripps Ara\u015ft\u0131rma G\u00f6revlisi Sai Pradeep Velagapudi yapt\u0131\u011f\u0131 a\u00e7\u0131klamada, “Gelecekte, bu stratejiyi, diren\u00e7li kanserlerden Zika ve Ebola gibi \u00f6nemli viral patojenlere kadar, hastal\u0131\u011fa neden olan di\u011fer RNA t\u00fcrlerini hedef almak i\u00e7in uygulamay\u0131 umuyoruz.” Dedi.<\/span><\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u00dc\u00e7l\u00fc negatif meme kanseri ara\u015ft\u0131rmas\u0131nda olumlu haberler Scripps Ara\u015ft\u0131rma Enstit\u00fcs\u00fc’ndeki ara\u015ft\u0131rmac\u0131lar taraf\u0131ndan yak\u0131n zamanda yap\u0131lan bir ara\u015ft\u0131rma, tedavisi en zor kanser t\u00fcrlerinden biri olan \u00fc\u00e7l\u00fc negatif meme kanserinin tedavisine \u0131\u015f\u0131k tutuyor. Ara\u015ft\u0131rma, gen ekspresyonunu ve protein geli\u015fimini d\u00fczenlemeye yard\u0131mc\u0131 olan mikroRNA’lar ad\u0131 verilen molek\u00fcllere odakland\u0131. Bilim adamlar\u0131, baz\u0131 \u00e7al\u0131\u015fmalarda birden fazla kanser t\u00fcr\u00fc ve di\u011fer …<\/p>\n","protected":false},"author":1,"featured_media":20004,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-21349","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-tr"],"yoast_head":"\n\u00dc\u00e7l\u00fc negatif meme kanseri ara\u015ft\u0131rmas\u0131nda olumlu haberler - zdmaa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zdmaa.com\/tr\/positive-news-in-triple-negative-breast-cancer-research\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00dc\u00e7l\u00fc negatif meme kanseri ara\u015ft\u0131rmas\u0131nda olumlu haberler - zdmaa\" \/>\n<meta property=\"og:description\" content=\"\u00dc\u00e7l\u00fc negatif meme kanseri ara\u015ft\u0131rmas\u0131nda olumlu haberler Scripps Ara\u015ft\u0131rma Enstit\u00fcs\u00fc’ndeki ara\u015ft\u0131rmac\u0131lar taraf\u0131ndan yak\u0131n zamanda yap\u0131lan bir ara\u015ft\u0131rma, tedavisi en zor kanser t\u00fcrlerinden biri olan \u00fc\u00e7l\u00fc negatif meme kanserinin tedavisine \u0131\u015f\u0131k tutuyor. 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Ara\u015ft\u0131rma, gen ekspresyonunu ve protein geli\u015fimini d\u00fczenlemeye yard\u0131mc\u0131 olan mikroRNA’lar ad\u0131 verilen molek\u00fcllere odakland\u0131. 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