{"id":22331,"date":"2022-01-11T20:37:33","date_gmt":"2022-01-11T17:37:33","guid":{"rendered":"https:\/\/zdmaa.com\/less-aggressive-cancer-therapies-more-common\/"},"modified":"2022-01-11T23:19:15","modified_gmt":"2022-01-11T20:19:15","slug":"less-aggressive-cancer-therapies-more-common","status":"publish","type":"post","link":"https:\/\/zdmaa.com\/tr\/less-aggressive-cancer-therapies-more-common\/","title":{"rendered":"Daha az \u015fiddetli kanser tedavileri daha yayg\u0131nd\u0131r"},"content":{"rendered":"

Daha az \u015fiddetli kanser tedavileri daha yayg\u0131nd\u0131r<\/span><\/span><\/span><\/span><\/p>\n

\n

Daha \u00f6nce kanserin yaln\u0131zca kitle imha yoluyla tedavi edilebilecek bir hastal\u0131k oldu\u011funa inan\u0131l\u0131yordu. <\/span><\/span><\/span>Doktorlar ve hastalar, kanseri \u00f6ld\u00fcrmenin tek yolunun, hastan\u0131n sa\u011fl\u0131\u011f\u0131n\u0131 ba\u015fka, bazen \u00f6nemli \u015fekillerde olumsuz etkilemek anlam\u0131na gelse bile, onu h\u0131zl\u0131 ve tamamen tedavi etmek oldu\u011funa inan\u0131rlar. <\/span><\/span><\/span>FACOS DO, CTCA Akci\u011fer Kanseri Enstit\u00fcs\u00fc g\u00f6\u011f\u00fcs cerrahisi direkt\u00f6r\u00fc Peter Baik, \u201cMaliyeti ne olursa olsun kanserden kurtulmak her zaman en b\u00fcy\u00fck \u00f6nceli\u011fimiz olmu\u015ftur\u201d diyor. <\/span><\/span><\/span>“Kanserli olan her \u015feye sald\u0131rmak istedik, bu y\u00fczden genellikle m\u00fcmk\u00fcn olan en agresif yakla\u015f\u0131m\u0131 se\u00e7tik.”<\/span><\/span><\/span><\/span><\/p>\n

Ge\u00e7mi\u015fte bu, bir uzvun amputasyonu, cerrahi kastrasyon veya g\u00f6\u011f\u00fcs kas\u0131n\u0131n tamamen \u00e7\u0131kar\u0131lmas\u0131 anlam\u0131na gelebilirdi. <\/span>Ancak bug\u00fcn, ki\u015fiselle\u015ftirilmi\u015f ve hassas t\u0131p \u00e7a\u011f\u0131nda, bu tek bedene uyan yakla\u015f\u0131m kaybolmu\u015ftur. <\/span>Bunun yerine, kanser tedavisi genellikle se\u00e7enekleri tartmak ve her hasta i\u00e7in neyin anlaml\u0131 oldu\u011funu belirlemek meselesidir. <\/span>\u00c7o\u011fu durumda, asl\u0131nda, kanser tedavisi s\u00f6z konusu oldu\u011funda, art\u0131k daha az\u0131 daha fazlad\u0131r.<\/span><\/span><\/span><\/span><\/p>\n

Hastalara ‘Karaci\u011fer metastaz\u0131n\u0131z var, bu y\u00fczden karaci\u011ferin bir k\u0131sm\u0131n\u0131 \u00e7\u0131karman\u0131z gerekiyor’ derdik. <\/span>” <\/span><\/span><\/span>\u015eimdi onlara s\u00f6yle,” karaci\u011ferde k\u00f6t\u00fc huylu bir t\u00fcm\u00f6r var, bu y\u00fczden sana sunulan <\/span>se\u00e7enekleri s\u0131rala.” ” <\/span><\/span><\/span>Farkl\u0131 se\u00e7eneklerde daha fazla zaman harc\u0131yoruz , <\/span>sadece devam et ve tedaviyi de\u011ferlendir ve bu se\u00e7eneklerin \u00e7o\u011fu daha fazlas\u0131n\u0131 sa\u011fl\u0131yor. Stephen Standford, MD, FACS, CTCA Philadelphia Cerrahi Onkolojisi gibi ge\u00e7mi\u015fte normal dokuyu tedavi eder.Onlarca <\/span><\/span><\/span>y\u0131l s\u00fcren ara\u015ft\u0131rmalardan sonra, bilim adamlar\u0131 ve onkologlar kanserin sadece bir hastal\u0131k olmad\u0131\u011f\u0131n\u0131, her birinin kendine \u00f6zg\u00fc \u00f6zellikleri ve ki\u015fiselle\u015ftirilmi\u015f tedavisi olan bir\u00e7ok hastal\u0131k oldu\u011funu ke\u015ffettiler. se\u00e7enekler. <\/span><\/span><\/span>Kanser, \u00f6rne\u011fin bir yakla\u015f\u0131m “N\u00fckleer” yan\u0131t verebilir, <\/span><\/span><\/span>ancak ba\u015fka bir hastal\u0131\u011f\u0131 kronik ama y\u00f6netilebilir biri olarak hastan\u0131n ya\u015fam\u0131 boyunca tedavi edilebilir.<\/span><\/span><\/span><\/span><\/p>\n

Ayr\u0131ca, kanser h\u00fccrelerinin benzersiz biyobelirte\u00e7lerini belirlemek i\u00e7in tasarlanm\u0131\u015f hedefe y\u00f6nelik terapi ve ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin kanser h\u00fccrelerini tan\u0131mas\u0131na ve sald\u0131rmas\u0131na yard\u0131mc\u0131 olan imm\u00fcnoterapi ila\u00e7lar\u0131 gibi daha hassas odakl\u0131 tedavilerin \u00f6n\u00fcn\u00fc a\u00e7maya yard\u0131mc\u0131 oldular.<\/span><\/span><\/span><\/span><\/p>\n

Kanseri daha iyi hedef alan bu tedaviler, sa\u011fl\u0131kl\u0131 h\u00fccreleri yok etmedikleri i\u00e7in genellikle kemoterapi ve di\u011fer standart y\u00f6ntemlerden daha az yan etkiye sahiptir. <\/span><\/span><\/span>CTCA Phoenix ba\u015f radyasyon onkolo\u011fu M.D., Marnie Spearer, \u201cKemoterapi gibi hedeflenmemi\u015f tedavilerle ilgili sorun, kurslar\u0131ndaki her \u015feyi etkileyebilmeleridir\u201d diyor. <\/span><\/span><\/span>“Tedavimize daha fazla odaklanabilece\u011fimizi ve daha do\u011frudan olabilece\u011fimizi \u00f6\u011freniyoruz ve bu nedenle potansiyel olarak hastalar\u0131 daha k\u0131sa s\u00fcrede, daha az tedavi ve daha az potansiyel yan etki ile tedavi ediyoruz.”<\/span><\/span><\/span><\/span><\/p>\n

Kanser tedavisinin evrimi: daha \u00e7oktan daha az\u0131na<\/span><\/span><\/span><\/span><\/strong><\/p>\n

1882’de Johns Hopkins \u00dcniversitesi’nde cerrahi profes\u00f6r\u00fc olan William Halstead, yakla\u015f\u0131k bir y\u00fczy\u0131l boyunca meme kanseri cerrahisi i\u00e7in bak\u0131m standard\u0131 haline gelen ilk radikal mastektomiyi ger\u00e7ekle\u015ftirdi. <\/span><\/span><\/span>Radikal bir mastektomi s\u0131ras\u0131nda cerrah meme dokusunu meme ba\u015f\u0131, koltuk alt\u0131ndaki lenf d\u00fc\u011f\u00fcmleri ve memenin alt\u0131ndaki g\u00f6\u011f\u00fcs duvar\u0131 kaslar\u0131 ile birlikte \u00e7\u0131kar\u0131r. <\/span><\/span><\/span>Ancak 100 y\u0131l sonra, 1980’lerde, klinik deneyler, lumpektominin e\u015fit derecede uygulanabilir bir se\u00e7enek oldu\u011funu ve hasta i\u00e7in daha az kapsaml\u0131 ve daha kolay oldu\u011funu, memenin kendisini de\u011fil birincil t\u00fcm\u00f6r\u00fc \u00e7\u0131kard\u0131\u011f\u0131n\u0131 buldu. <\/span><\/span><\/span>Dr. Standford, “Uygulama 1980’lerde ba\u015flad\u0131\u011f\u0131nda, mastektomi hemen hemen standartt\u0131 ve lumpektomi i\u00e7in potansiyel bir adaydan bahsediyorduk” diyor. <\/span><\/span><\/span>“\u015eimdi <\/span><\/span><\/span>tam tersi. <\/span><\/span><\/span>Kimin <\/span><\/span><\/span><\/span>olmad\u0131\u011f\u0131<\/span><\/span><\/span><\/em> hakk\u0131nda konu\u015fmak<\/span><\/span><\/span><\/span>Lumpektomi aday\u0131. <\/span><\/span><\/span>B\u00fct\u00fcn bak\u0131\u015f a\u00e7\u0131s\u0131 de\u011fi\u015fti.”<\/span><\/span><\/span><\/span><\/p>\n

Haziran ay\u0131nda, \u00e7\u0131\u011f\u0131r a\u00e7\u0131c\u0131 bir klinik ara\u015ft\u0131rma, erken evre meme kanserli kad\u0131nlar\u0131n \u00fc\u00e7te ikisinin kemoterapi ile tedavi edilmesine mutlaka ihtiya\u00e7 duymad\u0131\u011f\u0131n\u0131 tespit etti\u011finde, meme kanseri tedavi paradigmas\u0131 yeniden de\u011fi\u015fti. <\/span><\/span><\/span><\/span>New England Journal of Medicine’de<\/span><\/span><\/span><\/span><\/em><\/em> yay\u0131nlanan <\/span><\/span><\/span>bulgular <\/span><\/span><\/span>, <\/span><\/span><\/span><\/span>ortalama n\u00fcks riski olan (y\u0131lda yakla\u015f\u0131k 85.000 kad\u0131n) erken evre meme kanserli hastalar\u0131n \u00e7o\u011funun kemoterapi olmadan g\u00fcvenle yapabilece\u011fi sonucuna var\u0131yor.<\/span><\/span><\/span><\/span><\/p>\n

Prostat kanseri tedavisi de benzer bir geli\u015fme g\u00f6stermi\u015ftir. <\/span><\/span><\/span><\/span><\/span>Y\u00fczy\u0131l\u0131 a\u015fk\u0131n bir s\u00fcredir standart tedavi, ameliyat s\u0131ras\u0131nda prostat\u0131n \u00e7\u0131kar\u0131lmas\u0131n\u0131 gerektiriyordu. <\/span><\/span><\/span><\/span><\/span>Ancak ara\u015ft\u0131rmalar, prostat t\u00fcm\u00f6rlerinin \u00e7ok yava\u015f b\u00fcy\u00fcd\u00fc\u011f\u00fc i\u00e7in, \u00e7o\u011fu erke\u011fin kanserden ba\u015fka bir \u015feyden \u00f6lme olas\u0131l\u0131\u011f\u0131n\u0131n y\u00fcksek oldu\u011funu g\u00f6stermi\u015ftir. <\/span><\/span><\/span><\/span><\/span>Dolay\u0131s\u0131yla bug\u00fcn, erken evre prostat kanseri olan bir\u00e7ok erkek, idrar ka\u00e7\u0131rma ve iktidars\u0131zl\u0131k gibi potansiyel yan etkilerden ka\u00e7\u0131narak ameliyat yerine aktif g\u00f6zetimi tercih edebilir.<\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n

Benzer \u015fekilde, mesane kanseri olan hastalarda s\u0131kl\u0131kla sistektomi yap\u0131l\u0131r ve onlar\u0131 kal\u0131c\u0131 bir idrar toplama torbas\u0131 takmaya veya ba\u011f\u0131rsaktan yeni bir mesane olu\u015fturmak i\u00e7in ameliyat olmaya zorlar. <\/span><\/span><\/span><\/span><\/span>Bununla birlikte, belirli tipte mesane kanseri olan hastalar\u0131n mesanenin cerrahi olarak \u00e7\u0131kar\u0131lmas\u0131 i\u00e7in aktif izlemeyi se\u00e7ip se\u00e7emeyeceklerini ara\u015ft\u0131rmak i\u00e7in \u015fu anda bir klinik \u00e7al\u0131\u015fma devam etmektedir.<\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n

Ara\u015ft\u0131rmalar ayr\u0131ca baz\u0131 durumlarda, HPV’nin neden oldu\u011fu g\u0131rtlak kanseri olan hastalar\u0131n, kanseri HPV’nin neden olmad\u0131\u011f\u0131 hastalara g\u00f6re daha az invaziv tedaviler alabildi\u011fini bulmu\u015ftur. <\/span><\/span><\/span>A\u011fustos ay\u0131nda <\/span><\/span><\/span><\/span>New England Journal of Medicine’de<\/span><\/span><\/span><\/span><\/em> yay\u0131nlanan bir ara\u015ft\u0131rma <\/span><\/span><\/span><\/span>, ilerlemi\u015f b\u00f6brek kanserli bir\u00e7ok hastan\u0131n, g\u00fcn\u00fcm\u00fczde hastal\u0131\u011f\u0131 tedavi etmek i\u00e7in yayg\u0131n olarak kullan\u0131lan standart cerrahi ve kemoterapi kombinasyonu yerine tek ba\u015f\u0131na kemoterapi ile tedavi edilebilece\u011fini buldu.<\/span><\/span><\/span><\/span><\/p>\n

‘Az \u00e7oktur’ e\u011filimi radyoterapiye y\u00f6nelik bir\u00e7ok yakla\u015f\u0131m\u0131 da de\u011fi\u015ftirmi\u015ftir. <\/span><\/span><\/span><\/span><\/span>Ara\u015ft\u0131rmalar, daha d\u00fc\u015f\u00fck ancak daha g\u00fc\u00e7l\u00fc radyasyon dozlar\u0131n\u0131n, bir\u00e7ok kanser t\u00fcr\u00fcn\u00fcn tedavisinde daha d\u00fc\u015f\u00fck konsantrasyonlarda verilen ek dozlar kadar etkili oldu\u011funu giderek daha fazla buluyor. <\/span><\/span><\/span><\/span><\/span><\/span>ASCO Post’ta<\/span><\/span><\/span><\/span><\/span><\/span><\/em><\/em> Ekim 2017’de <\/span><\/span><\/span><\/span><\/span>yay\u0131nlanan \u00e7al\u0131\u015fma sonu\u00e7lar\u0131na g\u00f6re <\/span><\/span><\/span><\/span><\/span><\/span>, \u00f6rne\u011fin, “daha k\u0131sa, daha y\u00fcksek dozlu bir radyasyon \u015fekli g\u00fcvenli, etkili kabul edilir ve 50 ya\u015f\u0131ndan k\u00fc\u00e7\u00fck meme kanseri hastalar\u0131nda meme dokusuna veya cilde zarar vermez. ya\u015fl\u0131 hastalar.\u201d ya\u015f”. <\/span><\/span><\/span><\/span><\/span>Baz\u0131 erkekler prostat kanseri i\u00e7in \u00e7ok daha k\u0131sa radyasyon rejimlerini de se\u00e7ebilir. <\/span><\/span><\/span><\/span><\/span>Dr. Sperer, “Ge\u00e7mi\u015fte d\u00fczinelerce radyasyon tedavisi g\u00f6rm\u00fc\u015f belirli t\u00fcm\u00f6r t\u00fcrlerine sahip prostat kanserli hastalar \u015fimdi be\u015fe kadar uygun olabilir” diyor.<\/span><\/span><\/span><\/span><\/span>“Bu, son y\u0131llarda giderek daha fazla norm haline geldi.”<\/span><\/span><\/span><\/span><\/p>\n

ya\u015fam kalitesi fakt\u00f6r\u00fc<\/span><\/span><\/span><\/span><\/strong><\/p>\n

Ya\u015fam kalitesine odaklanma, agresif tedavileri azaltmada \u00f6nemli bir rol oynam\u0131\u015ft\u0131r. <\/span><\/span><\/span>Dr. Standiford, “T\u0131bb\u0131 uygulamaya ba\u015flad\u0131\u011f\u0131mda, ya\u015fam kalitesine bug\u00fcnk\u00fc kadar odaklanm\u0131yordum” diyor. <\/span><\/span><\/span>“Ge\u00e7mi\u015fte birisi ameliyattan sonra d\u00f6rt ay kemoterapi g\u00f6rseydi, onlara d\u00f6rt ay \u00e7al\u0131\u015famayacaklar\u0131n\u0131 <\/span><\/span><\/span>s\u00f6ylerdik <\/span><\/span><\/span>. <\/span><\/span>Bug\u00fcn size, Cuma g\u00fcn\u00fc kemoterapi alm\u0131\u015f olsayd\u0131n\u0131z, \u00e7al\u0131\u015fmaya geri d\u00f6nebilece\u011finizi s\u00f6yl\u00fcyoruz. Pazartesi. <\/span><\/span><\/span>Bug\u00fcn\u00fcn hastalar\u0131 kendi kararlar\u0131n\u0131 verebilmeyi ve m\u00fcmk\u00fcn olan en k\u0131sa s\u00fcrede normal hayata d\u00f6nebilmeyi istiyorlar.\u201d<\/span><\/span><\/span><\/span><\/p>\n

Hastalar\u0131n esenli\u011fine artan odaklanma, klinisyenleri bir \u00f6neride bulunmadan \u00f6nce tedaviyle ilgili risklere daha geni\u015f bir a\u00e7\u0131dan bakma konusunda da etkilemi\u015ftir. <\/span><\/span><\/span>Dr. Standiford, “Art\u0131k kanseri tedavi ederken t\u00fcm fakt\u00f6rleri tart\u0131yoruz” diyor. <\/span><\/span><\/span>“Sadece kanser riskleri de\u011fil, genel sa\u011fl\u0131k riskleri de.” <\/span><\/span><\/span>\u00d6rne\u011fin, sol meme kanseri nedeniyle radyasyon tedavisi g\u00f6ren bir kad\u0131n\u0131n, sa\u011f g\u00f6\u011fs\u00fcne radyasyon alan bir kad\u0131ndan daha y\u00fcksek kalp krizi riski vard\u0131r; bu, g\u00fcn\u00fcm\u00fczde klinisyenler i\u00e7in \u00f6nemli bir husustur. <\/span><\/span><\/span>Ek olarak, bir\u00e7ok cerrahi onkolog, ameliyat\u0131 \u00f6nermeden \u00f6nce akci\u011fer kanserli bir hasta \u00fczerindeki etkileri g\u00fc\u00e7l\u00fc bir \u015fekilde tartar. <\/span><\/span><\/span>“Birisi ameliyat olursa, muhtemelen hayatlar\u0131n\u0131n geri kalan\u0131nda kanserle ya\u015fayacakt\u0131r.<\/span><\/span><\/span>Ameliyattan sonra her g\u00fcn ekstra oksijen alman\u0131z gerekiyor, daha \u00f6nce hi\u00e7 yapmad\u0131\u011f\u0131n\u0131z bir \u015fey, kanseri iyile\u015ftirmi\u015f olabilirsiniz, ancak hastay\u0131 ger\u00e7ekten iyile\u015ftirdiniz mi? <\/span><\/span><\/span>Dr. Pike diyor.<\/span><\/span><\/span><\/span><\/p>\n

Benzer \u015fekilde, k\u00fc\u00e7\u00fck h\u00fccreli olmayan akci\u011fer kanseri olan bir hasta, akci\u011ferin y\u00fczde 40’a kadar\u0131n\u0131n \u00e7\u0131kar\u0131ld\u0131\u011f\u0131 lobektomiye alternatif olarak, kama rezeksiyonu veya akci\u011ferdeki kanserli h\u00fccrelerin cerrahi olarak \u00e7\u0131kar\u0131lmas\u0131n\u0131 se\u00e7ebilir, \u00e7\u00fcnk\u00fc daha az invazivdir. <\/span><\/span><\/span>Dr. Pike, bunun dikkate al\u0131nmas\u0131 gereken tek fakt\u00f6r olmamas\u0131 gerekti\u011fini s\u00f6yl\u00fcyor. <\/span><\/span><\/span>“Kama rezeksiyon ile n\u00fcks oran\u0131 y\u00fcksek olabilir, bu nedenle en az invaziv yolu se\u00e7mek her zaman do\u011fru se\u00e7im de\u011fildir” diyor. <\/span><\/span><\/span>“Dikkatli olmal\u0131s\u0131n. Evet, daha az ameliyat istiyoruz ama karar\u0131 analiz edip hi\u00e7bir \u015feyi ka\u00e7\u0131rmad\u0131\u011f\u0131m\u0131zdan emin olmal\u0131y\u0131z.”<\/span><\/span><\/span><\/span><\/p>\n

Kanser tedavisi se\u00e7eneklerini se\u00e7erken hastan\u0131n ya\u015f\u0131 ve sa\u011fl\u0131\u011f\u0131n\u0131n da g\u00f6z \u00f6n\u00fcnde bulundurulmas\u0131 \u00f6nemlidir. <\/span><\/span><\/span>Erken evre akci\u011fer kanseri olan bir hasta 90 ya\u015f\u0131ndaysa ve ameliyat\u0131 tolere edemiyorsa, \u00f6rne\u011fin radyasyon, sa\u011fl\u0131kl\u0131 doku \u00fczerinde daha az etki ile daha odakl\u0131 tedaviyi i\u00e7erdi\u011finden tercih edilen se\u00e7enek olabilir. <\/span><\/span><\/span>Asl\u0131nda, A\u011fustos ay\u0131nda <\/span><\/span><\/span><\/span>Amerikan Tabipler Birli\u011fi Dergisi’nde<\/span><\/span><\/span><\/span><\/em> yay\u0131nlanan bir ara\u015ft\u0131rma <\/span><\/span><\/span><\/span>, meme kanseri olan ya\u015fl\u0131 kad\u0131nlar i\u00e7in cerrahinin ya\u015fam kalitesini d\u00fc\u015f\u00fcrd\u00fc\u011f\u00fc i\u00e7in \u00f6nerilen se\u00e7enek olmayabilece\u011fini buldu.<\/span><\/span><\/span><\/span><\/p>\n

“<\/span><\/span><\/span><\/strong> Angelina Jolie <\/span><\/span><\/span><\/span>” nin <\/span><\/span><\/span><\/strong>etkisi<\/span><\/span><\/strong><\/span><\/span><\/strong><\/p>\n

Bununla birlikte, tedavi se\u00e7imine ili\u015fkin karar nihayetinde hastaya ba\u011fl\u0131d\u0131r. <\/span><\/span><\/span>Dr. Sperer, “Baz\u0131 hastalara radyoterapinin tedavilerine \u00e7ok az fayda sa\u011flayaca\u011f\u0131 s\u00f6ylendi” diyor. <\/span><\/span><\/span>Ama baz\u0131lar\u0131 yine de bunu yapmay\u0131 se\u00e7ecek. <\/span><\/span><\/span>Her \u015feyi istiyorlar. <\/span><\/span><\/span>Ancak anlamad\u0131klar\u0131 \u015fey, ‘her \u015feyin’ hala iyile\u015fmelerini garanti etmemesi ve tedaviden hala yan etkilerinin olmas\u0131.”<\/span><\/span><\/span><\/span><\/p>\n

Baz\u0131 doktorlar, hakl\u0131 olmasa bile, daha agresif tedaviler isteyenlerin genellikle gen\u00e7 kad\u0131nlar oldu\u011funu s\u00f6yl\u00fcyor. <\/span><\/span><\/span>Bu e\u011filim genellikle “Angelina Jolie etkisi” olarak bilinir; aktris Angelina Jolie’nin <\/span><\/span><\/span>2013 y\u0131l\u0131nda <\/span><\/span><\/span><\/span>New York Times’ta yay\u0131nlanan bir<\/span><\/span><\/span><\/span><\/em> g\u00f6r\u00fc\u015f <\/span><\/span><\/span>yaz\u0131s\u0131nda, bir ta\u015f\u0131y\u0131c\u0131 oldu\u011funu \u00f6\u011frendikten sonra \u00f6nleyici bir \u00e7ift mastektomi ge\u00e7irdi\u011fini <\/span><\/span><\/span>a\u00e7\u0131klamas\u0131n\u0131n yaratt\u0131\u011f\u0131 etkiyi tan\u0131mlamak i\u00e7in kullan\u0131lan bir terimdir <\/span><\/span><\/span><\/span>. gen mutasyonu BRCA1.<\/span><\/span><\/span><\/span><\/p>\n

Dr. Standford, “Gen\u00e7ler genellikle meme kanserine erken yakalan\u0131r, ancak bir daha asla endi\u015felenmemeleri i\u00e7in \u00e7ift mastektomi yap\u0131lmas\u0131n\u0131 isterler” diyor. <\/span><\/span><\/span>“Ya\u015fl\u0131 hastalar\u0131n, yapabildiklerinde daha az tedaviye devam etme olas\u0131l\u0131klar\u0131 daha y\u00fcksektir.” <\/span><\/span><\/span>Ancak, gerek\u00e7elendirilmese bile daha agresif bir tedavi se\u00e7en hastalar, belirli meme kanseri gen mutasyonlar\u0131n\u0131 ta\u015f\u0131d\u0131klar\u0131 i\u00e7in yumurtal\u0131k, pankreas ve kolorektal kanser dahil olmak \u00fczere di\u011fer kanser risklerinin de y\u00fcksek oldu\u011fu ger\u00e7e\u011fini genellikle g\u00f6zden ka\u00e7\u0131r\u0131rlar. <\/span><\/span><\/span>“Kanserle daha agresif olmak sizi sonsuza kadar kanserden kurtarmaz” diyor. <\/span><\/span><\/span>“Tek durak de\u011fil. <\/span><\/span><\/span>\u00d6m\u00fcr boyu kanser te\u015fhisi.”<\/span><\/span><\/span><\/span><\/p>\n

Gerekli olmayan tedavi se\u00e7imi genellikle ki\u015fiden ki\u015fiye de\u011fi\u015febilen bireysel bir karard\u0131r. <\/span><\/span><\/span>Dr. Standiford, “Herkesin farkl\u0131 bir gri alana sahip oldu\u011funu \u00f6\u011frendim” diyor. <\/span><\/span><\/span>“Doktorlar\u0131 onlara sadece y\u00fczde 2 fayda sa\u011flayaca\u011f\u0131n\u0131 s\u00f6ylese bile hala kemoterapi istedi\u011fini s\u00f6yleyenler <\/span><\/span><\/span>var <\/span><\/span><\/span>. <\/span><\/span>Ama y\u00fczde 20 fayda sa\u011fl\u0131yorsa kemoterapiyi reddeden insanlar da var. <\/span><\/span><\/span>Y\u00fczde yirmi yeterince b\u00fcy\u00fck de\u011fil. bu insanlar i\u00e7in say\u0131. . <\/span><\/span><\/span>bug\u00fcn, kimin kemoterapiye ihtiyac\u0131 olmad\u0131\u011f\u0131n\u0131 belirlemekle s\u0131n\u0131rl\u0131 de\u011fil. <\/span><\/span><\/span>Ki\u015filerin <\/span><\/span>kemoterapi <\/span><\/span><\/span>almak isteyip istemedikleri konusunda bilin\u00e7li bir karar vermelerini sa\u011fl\u0131yor <\/span>. “<\/span><\/span><\/span><\/span><\/p>\n

En az a\u015fa\u011f\u0131l\u0131k anlam\u0131na gelmez<\/span><\/span><\/span><\/span><\/strong><\/p>\n

Gelecekte, klinisyenler ara\u015ft\u0131rmac\u0131lar\u0131n belirli bir t\u00fcm\u00f6r\u00fcn tedaviye nas\u0131l yan\u0131t verece\u011fini tahmin etmeye yard\u0131mc\u0131 olacak biyobelirte\u00e7leri ke\u015ffetmeye devam edece\u011fini umuyor, b\u00f6ylece daha hedefe y\u00f6nelik tedaviler geli\u015ftirilebilir. <\/span><\/span><\/span>Dr. Standiford, “Doktor olmak e\u011flenceli, stresli ve zorlu bir d\u00f6nem” diyor. <\/span><\/span><\/span>“30 y\u0131ld\u0131r e\u011fitim al\u0131yorum ve t\u0131p fak\u00fcltesindeyken T h\u00fccreleri ve B h\u00fccreleri hakk\u0131nda \u00f6\u011freniyorduk. Ba\u011f\u0131\u015f\u0131kl\u0131k sistemi hakk\u0131nda bildi\u011fimiz tek \u015fey buydu. <\/span><\/span><\/span>Ara\u015ft\u0131rmac\u0131lar\u0131n \u015fu anda \u00f6\u011frendi\u011fi bir\u00e7ok karma\u015f\u0131k \u015fey var. asla hayal edemeyece\u011fimiz bir \u015feydi.”<\/span><\/span><\/span><\/span><\/p>\n

Bilim insanlar\u0131n\u0131n bug\u00fcn \u00f6\u011frendiklerinin \u00e7o\u011fu, son y\u0131llarda teknolojideki \u00f6nemli geli\u015fmeler sayesinde m\u00fcmk\u00fcn. <\/span><\/span><\/span>Dr. Pike, “Az \u00e7oktur” g\u00fcncel konu \u00e7\u00fcnk\u00fc daha fazlas\u0131n\u0131 biliyoruz, diyor. <\/span><\/span><\/span>“Son 20-30 y\u0131lda \u00e7ok fazla veri g\u00f6rd\u00fck. <\/span><\/span><\/span>Ondan \u00f6nce doktorlar\u0131n yapt\u0131klar\u0131n\u0131n \u00e7o\u011fu kan\u0131ta dayanm\u0131yordu. <\/span><\/span><\/span>Her \u015feyi ka\u011f\u0131da <\/span><\/span><\/span>d\u00f6kmeye <\/span><\/span>devam <\/span><\/span>ediyorduk <\/span><\/span>. <\/span><\/span><\/span>\u015eimdi daha fazla kan\u0131t var ve daha fazla \u00e7al\u0131\u015fma ve ara\u015ft\u0131rma var. . yap\u0131l\u0131yor <\/span><\/span><\/span>. \u015eimdi biz onbinlerce okuyorsan\u0131z “hastalardan ve sonu\u00e7lar\u0131n\u0131 analiz eder. <\/span><\/span><\/span>Biz sonu\u00e7lar\u0131 belli t\u00fcrleri ve kanser a\u015famalar\u0131 i\u00e7in ne olaca\u011f\u0131 daha bilin\u00e7li.”<\/span><\/span><\/span><\/span><\/p>\n

Bununla birlikte, en \u00f6nemli sonu\u00e7, daha az tedavinin daha az tedavi anlam\u0131na gelmedi\u011fi olabilir. <\/span><\/span><\/span>Dr. Pike, “‘Daha az’, belirli \u015feyleri yapmak zorunda olmad\u0131\u011f\u0131m\u0131z\u0131 kan\u0131tlamak i\u00e7in bilimsel kan\u0131t kullanmak anlam\u0131na gelir” diyor. <\/span><\/span><\/span>“Ayn\u0131 sonu\u00e7lar\u0131 elde ederken bununla daha az ba\u015fa \u00e7\u0131kabiliriz.”<\/span><\/span><\/span><\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Daha az \u015fiddetli kanser tedavileri daha yayg\u0131nd\u0131r Daha \u00f6nce kanserin yaln\u0131zca kitle imha yoluyla tedavi edilebilecek bir hastal\u0131k oldu\u011funa inan\u0131l\u0131yordu. Doktorlar ve hastalar, kanseri \u00f6ld\u00fcrmenin tek yolunun, hastan\u0131n sa\u011fl\u0131\u011f\u0131n\u0131 ba\u015fka, bazen \u00f6nemli \u015fekillerde olumsuz etkilemek anlam\u0131na gelse bile, onu h\u0131zl\u0131 ve tamamen tedavi etmek oldu\u011funa inan\u0131rlar. FACOS DO, CTCA Akci\u011fer Kanseri Enstit\u00fcs\u00fc g\u00f6\u011f\u00fcs cerrahisi direkt\u00f6r\u00fc …<\/p>\n","protected":false},"author":1,"featured_media":22045,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-22331","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-tr"],"yoast_head":"\nDaha az \u015fiddetli kanser tedavileri daha yayg\u0131nd\u0131r - zdmaa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zdmaa.com\/tr\/less-aggressive-cancer-therapies-more-common\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Daha az \u015fiddetli kanser tedavileri daha yayg\u0131nd\u0131r - zdmaa\" \/>\n<meta property=\"og:description\" content=\"Daha az \u015fiddetli kanser tedavileri daha yayg\u0131nd\u0131r Daha \u00f6nce kanserin yaln\u0131zca kitle imha yoluyla tedavi edilebilecek bir hastal\u0131k oldu\u011funa inan\u0131l\u0131yordu. Doktorlar ve hastalar, kanseri \u00f6ld\u00fcrmenin tek yolunun, hastan\u0131n sa\u011fl\u0131\u011f\u0131n\u0131 ba\u015fka, bazen \u00f6nemli \u015fekillerde olumsuz etkilemek anlam\u0131na gelse bile, onu h\u0131zl\u0131 ve tamamen tedavi etmek oldu\u011funa inan\u0131rlar. FACOS DO, CTCA Akci\u011fer Kanseri Enstit\u00fcs\u00fc g\u00f6\u011f\u00fcs cerrahisi direkt\u00f6r\u00fc …\" \/>\n<meta property=\"og:url\" content=\"https:\/\/zdmaa.com\/tr\/less-aggressive-cancer-therapies-more-common\/\" \/>\n<meta property=\"og:site_name\" content=\"zdmaa\" \/>\n<meta property=\"article:published_time\" content=\"2022-01-11T17:37:33+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-01-11T20:19:15+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/zdmaa.com\/wp-content\/uploads\/2022\/01\/hospital-gcf9a8679a_640.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"640\" \/>\n\t<meta property=\"og:image:height\" content=\"426\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Yazan:\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tahmini okuma s\u00fcresi\" \/>\n\t<meta name=\"twitter:data2\" content=\"11 dakika\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/zdmaa.com\/tr\/less-aggressive-cancer-therapies-more-common\/\",\"url\":\"https:\/\/zdmaa.com\/tr\/less-aggressive-cancer-therapies-more-common\/\",\"name\":\"Daha az \u015fiddetli kanser tedavileri daha yayg\u0131nd\u0131r - zdmaa\",\"isPartOf\":{\"@id\":\"https:\/\/zdmaa.com\/tr\/ro\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/zdmaa.com\/tr\/less-aggressive-cancer-therapies-more-common\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/zdmaa.com\/tr\/less-aggressive-cancer-therapies-more-common\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/zdmaa.com\/wp-content\/uploads\/2022\/01\/hospital-gcf9a8679a_640.jpg\",\"datePublished\":\"2022-01-11T17:37:33+00:00\",\"dateModified\":\"2022-01-11T20:19:15+00:00\",\"author\":{\"@id\":\"https:\/\/zdmaa.com\/tr\/ro\/#\/schema\/person\/8aad4cf5d562d4ca835487f6149853e3\"},\"breadcrumb\":{\"@id\":\"https:\/\/zdmaa.com\/tr\/less-aggressive-cancer-therapies-more-common\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/zdmaa.com\/tr\/less-aggressive-cancer-therapies-more-common\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/zdmaa.com\/tr\/less-aggressive-cancer-therapies-more-common\/#primaryimage\",\"url\":\"https:\/\/zdmaa.com\/wp-content\/uploads\/2022\/01\/hospital-gcf9a8679a_640.jpg\",\"contentUrl\":\"https:\/\/zdmaa.com\/wp-content\/uploads\/2022\/01\/hospital-gcf9a8679a_640.jpg\",\"width\":640,\"height\":426,\"caption\":\"Less Aggressive Cancer Therapies More Common\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/zdmaa.com\/tr\/less-aggressive-cancer-therapies-more-common\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0629\",\"item\":\"https:\/\/zdmaa.com\/tr\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Daha az \u015fiddetli kanser tedavileri daha yayg\u0131nd\u0131r\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/zdmaa.com\/tr\/ro\/#website\",\"url\":\"https:\/\/zdmaa.com\/tr\/ro\/\",\"name\":\"zdmaa\",\"description\":\"zdmaa\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/zdmaa.com\/tr\/ro\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"tr\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/zdmaa.com\/tr\/ro\/#\/schema\/person\/8aad4cf5d562d4ca835487f6149853e3\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/zdmaa.com\/tr\/ro\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/zdmaa.com\/wp-content\/litespeed\/avatar\/dff6d89ac221c1aaf9366bf5b4cd32de.jpg?ver=1775954700\",\"contentUrl\":\"https:\/\/zdmaa.com\/wp-content\/litespeed\/avatar\/dff6d89ac221c1aaf9366bf5b4cd32de.jpg?ver=1775954700\",\"caption\":\"admin\"},\"sameAs\":[\"https:\/\/zdmaa.com\"],\"url\":\"https:\/\/zdmaa.com\/tr\/author\/admin\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Daha az \u015fiddetli kanser tedavileri daha yayg\u0131nd\u0131r - zdmaa","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/zdmaa.com\/tr\/less-aggressive-cancer-therapies-more-common\/","og_locale":"tr_TR","og_type":"article","og_title":"Daha az \u015fiddetli kanser tedavileri daha yayg\u0131nd\u0131r - zdmaa","og_description":"Daha az \u015fiddetli kanser tedavileri daha yayg\u0131nd\u0131r Daha \u00f6nce kanserin yaln\u0131zca kitle imha yoluyla tedavi edilebilecek bir hastal\u0131k oldu\u011funa inan\u0131l\u0131yordu. Doktorlar ve hastalar, kanseri \u00f6ld\u00fcrmenin tek yolunun, hastan\u0131n sa\u011fl\u0131\u011f\u0131n\u0131 ba\u015fka, bazen \u00f6nemli \u015fekillerde olumsuz etkilemek anlam\u0131na gelse bile, onu h\u0131zl\u0131 ve tamamen tedavi etmek oldu\u011funa inan\u0131rlar. FACOS DO, CTCA Akci\u011fer Kanseri Enstit\u00fcs\u00fc g\u00f6\u011f\u00fcs cerrahisi direkt\u00f6r\u00fc …","og_url":"https:\/\/zdmaa.com\/tr\/less-aggressive-cancer-therapies-more-common\/","og_site_name":"zdmaa","article_published_time":"2022-01-11T17:37:33+00:00","article_modified_time":"2022-01-11T20:19:15+00:00","og_image":[{"width":640,"height":426,"url":"https:\/\/zdmaa.com\/wp-content\/uploads\/2022\/01\/hospital-gcf9a8679a_640.jpg","type":"image\/jpeg"}],"author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Yazan:":"admin","Tahmini okuma s\u00fcresi":"11 dakika"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/zdmaa.com\/tr\/less-aggressive-cancer-therapies-more-common\/","url":"https:\/\/zdmaa.com\/tr\/less-aggressive-cancer-therapies-more-common\/","name":"Daha az \u015fiddetli kanser tedavileri daha yayg\u0131nd\u0131r - zdmaa","isPartOf":{"@id":"https:\/\/zdmaa.com\/tr\/ro\/#website"},"primaryImageOfPage":{"@id":"https:\/\/zdmaa.com\/tr\/less-aggressive-cancer-therapies-more-common\/#primaryimage"},"image":{"@id":"https:\/\/zdmaa.com\/tr\/less-aggressive-cancer-therapies-more-common\/#primaryimage"},"thumbnailUrl":"https:\/\/zdmaa.com\/wp-content\/uploads\/2022\/01\/hospital-gcf9a8679a_640.jpg","datePublished":"2022-01-11T17:37:33+00:00","dateModified":"2022-01-11T20:19:15+00:00","author":{"@id":"https:\/\/zdmaa.com\/tr\/ro\/#\/schema\/person\/8aad4cf5d562d4ca835487f6149853e3"},"breadcrumb":{"@id":"https:\/\/zdmaa.com\/tr\/less-aggressive-cancer-therapies-more-common\/#breadcrumb"},"inLanguage":"tr","potentialAction":[{"@type":"ReadAction","target":["https:\/\/zdmaa.com\/tr\/less-aggressive-cancer-therapies-more-common\/"]}]},{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/zdmaa.com\/tr\/less-aggressive-cancer-therapies-more-common\/#primaryimage","url":"https:\/\/zdmaa.com\/wp-content\/uploads\/2022\/01\/hospital-gcf9a8679a_640.jpg","contentUrl":"https:\/\/zdmaa.com\/wp-content\/uploads\/2022\/01\/hospital-gcf9a8679a_640.jpg","width":640,"height":426,"caption":"Less Aggressive Cancer Therapies More Common"},{"@type":"BreadcrumbList","@id":"https:\/\/zdmaa.com\/tr\/less-aggressive-cancer-therapies-more-common\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0629","item":"https:\/\/zdmaa.com\/tr\/"},{"@type":"ListItem","position":2,"name":"Daha az \u015fiddetli kanser tedavileri daha yayg\u0131nd\u0131r"}]},{"@type":"WebSite","@id":"https:\/\/zdmaa.com\/tr\/ro\/#website","url":"https:\/\/zdmaa.com\/tr\/ro\/","name":"zdmaa","description":"zdmaa","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/zdmaa.com\/tr\/ro\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"tr"},{"@type":"Person","@id":"https:\/\/zdmaa.com\/tr\/ro\/#\/schema\/person\/8aad4cf5d562d4ca835487f6149853e3","name":"admin","image":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/zdmaa.com\/tr\/ro\/#\/schema\/person\/image\/","url":"https:\/\/zdmaa.com\/wp-content\/litespeed\/avatar\/dff6d89ac221c1aaf9366bf5b4cd32de.jpg?ver=1775954700","contentUrl":"https:\/\/zdmaa.com\/wp-content\/litespeed\/avatar\/dff6d89ac221c1aaf9366bf5b4cd32de.jpg?ver=1775954700","caption":"admin"},"sameAs":["https:\/\/zdmaa.com"],"url":"https:\/\/zdmaa.com\/tr\/author\/admin\/"}]}},"_links":{"self":[{"href":"https:\/\/zdmaa.com\/tr\/wp-json\/wp\/v2\/posts\/22331","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zdmaa.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zdmaa.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zdmaa.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/zdmaa.com\/tr\/wp-json\/wp\/v2\/comments?post=22331"}],"version-history":[{"count":2,"href":"https:\/\/zdmaa.com\/tr\/wp-json\/wp\/v2\/posts\/22331\/revisions"}],"predecessor-version":[{"id":22351,"href":"https:\/\/zdmaa.com\/tr\/wp-json\/wp\/v2\/posts\/22331\/revisions\/22351"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/zdmaa.com\/tr\/wp-json\/wp\/v2\/media\/22045"}],"wp:attachment":[{"href":"https:\/\/zdmaa.com\/tr\/wp-json\/wp\/v2\/media?parent=22331"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zdmaa.com\/tr\/wp-json\/wp\/v2\/categories?post=22331"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zdmaa.com\/tr\/wp-json\/wp\/v2\/tags?post=22331"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}