{"id":22500,"date":"2022-01-11T20:15:10","date_gmt":"2022-01-11T17:15:10","guid":{"rendered":"https:\/\/zdmaa.com\/why-do-some-cancer-drugs-work-for-them-and-not-others\/"},"modified":"2022-01-12T00:58:32","modified_gmt":"2022-01-11T21:58:32","slug":"why-do-some-cancer-drugs-work-for-them-and-not-others","status":"publish","type":"post","link":"https:\/\/zdmaa.com\/tr\/why-do-some-cancer-drugs-work-for-them-and-not-others\/","title":{"rendered":"Neden baz\u0131 kanser ila\u00e7lar\u0131 onlarla birlikte \u00e7al\u0131\u015f\u0131yor, di\u011ferleri de\u011fil?"},"content":{"rendered":"

Neden baz\u0131 kanser ila\u00e7lar\u0131 onlarla birlikte \u00e7al\u0131\u015f\u0131yor, di\u011ferleri de\u011fil?<\/span><\/span><\/span><\/span><\/p>\n

\n

W.<\/span><\/span><\/span> Hen ara\u015ft\u0131rmac\u0131lar\u0131 yeni bir kanser ilac\u0131 \u00fczerinde klinik bir deney y\u00fcr\u00fct\u00fcyor ve tedavi \u00e7o\u011fu hasta i\u00e7in \u00e7o\u011fu zaman i\u015fe yaram\u0131yor. <\/span>Ancak bazen belirli bir hasta o kadar iyi tepki verir ki, kanser b\u00fcy\u00fcmeyi durdurur ve hatta tamamen yok olur. <\/span>Bu hastalar o kadar e\u015fsizdir ki bilim adamlar\u0131n\u0131n onlar i\u00e7in \u00f6zel bir ad\u0131 vard\u0131r: gergedan. <\/span>\u0130stisnai m\u00fcdahaleciler olarak da bilinen bu s\u0131ra d\u0131\u015f\u0131 hastalar, di\u011ferleri vermedi\u011finde neden bu kadar olumlu tepkiler verdikleri ve \u00f6\u011frenmenin di\u011fer hastalara nas\u0131l yard\u0131mc\u0131 olabilece\u011fi konusunda art\u0131k kapsaml\u0131 ara\u015ft\u0131rmalar\u0131n konusu.<\/span><\/span><\/p>\n

“Bu, kanser tedavisinin Kutsal K\u00e2sesi – bu hastalar\u0131 benzersiz k\u0131lan \u015feyin bulunmas\u0131. Belirli bir hastada kanserle sava\u015fmaya yard\u0131mc\u0131 olabilecek mucizevi bir \u00e7\u00f6z\u00fcm.” <\/span><\/span>– Arturo Loaiza-Bonilla, MD, MSEd, FACP – Philadelphia’daki Hastanemizde Klinik Onkoloji \u015eefi ve T\u0131bbi Ara\u015ft\u0131rma Direkt\u00f6r\u00fc<\/span><\/span><\/em><\/p><\/blockquote>\n

\u00c7al\u0131\u015fma yeni bir \u0131\u015f\u0131k tutuyor<\/span><\/span><\/h2>\n

Ge\u00e7mi\u015fte, 10 hastadan sadece 1’i yeni bir ilaca yan\u0131t verseydi, ara\u015ft\u0131rmac\u0131lar tedavinin bu kanser t\u00fcr\u00fc i\u00e7in etkili olmad\u0131\u011f\u0131n\u0131 ve bu t\u00fcr ara\u015ft\u0131rmalar\u0131 kesece\u011fini varsay\u0131yordu. <\/span>Ancak 2012’de yay\u0131nlanan bir \u00e7al\u0131\u015fma, istisnai m\u00fcdahaleciler hakk\u0131ndaki geleneksel d\u00fc\u015f\u00fcnceyi de\u011fi\u015ftirdi. <\/span>\u00c7al\u0131\u015fma, klinik bir deneye kat\u0131lan ileri evre mesane kanseri olan bir hastan\u0131n, deneydeki di\u011fer 44 kat\u0131l\u0131mc\u0131dan a\u00e7\u0131k\u00e7a farkl\u0131 olan, hedefe y\u00f6nelik tedaviye “dikkate de\u011fer bir yan\u0131t” verdi\u011fini g\u00f6sterdi. <\/span>B\u00f6ylece ara\u015ft\u0131rmac\u0131lar daha derine inmeye karar verdiler. <\/span>Bir kad\u0131n\u0131n t\u00fcm\u00f6r DNA’s\u0131n\u0131n molek\u00fcler testinden sonra, ara\u015ft\u0131rmac\u0131lar \u00e7o\u011fu mesane kanseri hastas\u0131nda iki nadir gen mutasyonu ke\u015ffettiler. <\/span>Ancak mutasyonlar mevcut oldu\u011funda, t\u00fcm\u00f6r\u00fc tedaviye daha a\u00e7\u0131k hale getirirler.<\/span><\/span><\/p>\n

Ara\u015ft\u0131rmac\u0131lar, istisnai yan\u0131t verenlerdeki t\u00fcm\u00f6rlerin y\u00fczde 10 ila 20’sinin al\u0131\u015f\u0131lmad\u0131k derecede y\u00fcksek say\u0131da genetik mutasyona sahip oldu\u011funu bulmu\u015flard\u0131r; bu, t\u00fcm\u00f6rlerin imm\u00fcnoterapi ila\u00e7lar\u0131na yan\u0131t verme olas\u0131l\u0131\u011f\u0131n\u0131 art\u0131rabilir. <\/span>Biyomark\u0131rlar\u0131n en \u00f6nemli tan\u0131mlar\u0131, t\u00fcm\u00f6r\u00fcn en \u00f6nemli de\u011fi\u015fikliklerinin en \u00f6nemlileridir. <\/span>Dr. Bonilla, “Art\u0131k t\u00fcm\u00f6r\u00fcn\u00fcz\u00fcn belirli bir \u00f6zelli\u011fi oldu\u011funda, imm\u00fcnoterapiye yan\u0131t verme olas\u0131l\u0131\u011f\u0131n\u0131n daha y\u00fcksek oldu\u011funu biliyoruz, bu y\u00fczden \u00e7ok daha iyi sonu\u00e7 verecektir” diyor. <\/span>“Hastalar daha \u00f6nce sahip olmad\u0131klar\u0131 bir avantaja sahipler.”<\/span><\/span><\/p>\n

Geli\u015fmi\u015f genomik testler nas\u0131l yard\u0131mc\u0131 olabilir?<\/span><\/span><\/h2>\n

Bu yeni bilgiyle donanm\u0131\u015f uzmanlar, kanserleri standart tedavilere yan\u0131t vermiyorsa hastalar\u0131 doktorlar\u0131yla geli\u015fmi\u015f genomik testler hakk\u0131nda konu\u015fmaya te\u015fvik ediyor. <\/span>Dr. Bonilla, “Hastalar onlar\u0131n savunucusu olmal\u0131d\u0131r” diyor. <\/span>“\u00d6rne\u011fin kemoterapiye yan\u0131t vermeyen baz\u0131 hastalar\u0131 inceledi\u011fimde, t\u00fcm\u00f6rlerinde belirli bir DNA mutasyonu oldu\u011funu buldum, bu da onlar\u0131n belirli bir t\u00fcr imm\u00fcnoterapi ilac\u0131 i\u00e7in aday olduklar\u0131 anlam\u0131na geliyordu, ki biz bunu yapmazd\u0131k. Aksini bilemeyiz.\u201d Hastalar\u0131n t\u00fcm\u00f6rlerini test etmenin ara\u015ft\u0131rma d\u00fcnyas\u0131na ve muhtemelen di\u011fer hastalara ek bir faydas\u0131 vard\u0131r.<\/span><\/span><\/p>\n

Dr. Bonilla \u015funlar\u0131 ekliyor: Ara\u015ft\u0131rmac\u0131lar biyobelirte\u00e7 testleri ne kadar \u00e7ok ger\u00e7ekle\u015ftirirse, bilim camias\u0131n\u0131n ola\u011fan\u00fcst\u00fc yan\u0131t verenleri belirleme olas\u0131l\u0131\u011f\u0131 o kadar artar. <\/span>Dr. Bonilla, \u201cNe kadar istisnai m\u00fcdahaleci \u00fczerinde \u00e7al\u0131\u015f\u0131rsak, tedavileri daha fazla insana yard\u0131m etmek i\u00e7in o kadar \u00e7ok \u00f6zelle\u015ftirebiliriz\u201d diyor.<\/span><\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Neden baz\u0131 kanser ila\u00e7lar\u0131 onlarla birlikte \u00e7al\u0131\u015f\u0131yor, di\u011ferleri de\u011fil? W. Hen ara\u015ft\u0131rmac\u0131lar\u0131 yeni bir kanser ilac\u0131 \u00fczerinde klinik bir deney y\u00fcr\u00fct\u00fcyor ve tedavi \u00e7o\u011fu hasta i\u00e7in \u00e7o\u011fu zaman i\u015fe yaram\u0131yor. Ancak bazen belirli bir hasta o kadar iyi tepki verir ki, kanser b\u00fcy\u00fcmeyi durdurur ve hatta tamamen yok olur. Bu hastalar o kadar e\u015fsizdir ki …<\/p>\n","protected":false},"author":1,"featured_media":21955,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-22500","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-tr"],"yoast_head":"\nNeden baz\u0131 kanser ila\u00e7lar\u0131 onlarla birlikte \u00e7al\u0131\u015f\u0131yor, di\u011ferleri de\u011fil? - zdmaa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zdmaa.com\/tr\/why-do-some-cancer-drugs-work-for-them-and-not-others\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Neden baz\u0131 kanser ila\u00e7lar\u0131 onlarla birlikte \u00e7al\u0131\u015f\u0131yor, di\u011ferleri de\u011fil? - zdmaa\" \/>\n<meta property=\"og:description\" content=\"Neden baz\u0131 kanser ila\u00e7lar\u0131 onlarla birlikte \u00e7al\u0131\u015f\u0131yor, di\u011ferleri de\u011fil? W. Hen ara\u015ft\u0131rmac\u0131lar\u0131 yeni bir kanser ilac\u0131 \u00fczerinde klinik bir deney y\u00fcr\u00fct\u00fcyor ve tedavi \u00e7o\u011fu hasta i\u00e7in \u00e7o\u011fu zaman i\u015fe yaram\u0131yor. Ancak bazen belirli bir hasta o kadar iyi tepki verir ki, kanser b\u00fcy\u00fcmeyi durdurur ve hatta tamamen yok olur. 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