{"id":22917,"date":"2022-01-11T17:11:21","date_gmt":"2022-01-11T14:11:21","guid":{"rendered":"https:\/\/zdmaa.com\/tiny-chromosome-tips-say-youre-older-than-you-are\/"},"modified":"2022-01-12T04:10:26","modified_gmt":"2022-01-12T01:10:26","slug":"tiny-chromosome-tips-say-youre-older-than-you-are","status":"publish","type":"post","link":"https:\/\/zdmaa.com\/tr\/tiny-chromosome-tips-say-youre-older-than-you-are\/","title":{"rendered":"K\u00fc\u00e7\u00fck kromozom u\u00e7lar\u0131, sizden b\u00fcy\u00fck oldu\u011funuzu g\u00f6sterir."},"content":{"rendered":"

K\u00fc\u00e7\u00fck kromozom u\u00e7lar\u0131, sizden b\u00fcy\u00fck oldu\u011funuzu g\u00f6sterir.<\/span><\/span><\/span><\/span><\/p>\n

\n

W<\/span><\/span><\/span>Hepimiz kronolojik olarak ka\u00e7 ya\u015f\u0131nda oldu\u011fumuzu biliyoruz. <\/span>Ama biyolojik olarak ka\u00e7 ya\u015f\u0131nda oldu\u011fumuzu biliyor muyuz? <\/span>Herkes farkl\u0131 oranlarda ya\u015flan\u0131r. <\/span>Ya\u015fam tarz\u0131, genetik, stres ve di\u011fer fakt\u00f6rler, g\u00f6r\u00fcnd\u00fc\u011f\u00fcm\u00fczden daha gen\u00e7 kalmam\u0131za veya ya\u015f\u0131m\u0131z\u0131n \u00f6tesinde ya\u015flanmam\u0131za katk\u0131da bulunur. <\/span>\u0130\u00e7 ya\u015flanma s\u00fcrecinin a\u00e7\u0131klay\u0131c\u0131 bir i\u015fareti, her birimizin derinliklerinde, her kromozomun ucundaki \u00e7ok k\u00fc\u00e7\u00fck DNA protein dizilerinde bulunabilir. <\/span>Bilim adamlar\u0131 y\u0131llard\u0131r telomer ad\u0131 verilen bu kromozomal u\u00e7lar\u0131n biyolojik ya\u015f\u0131m\u0131z\u0131 \u00f6l\u00e7mede oynad\u0131\u011f\u0131 rol\u00fc ve kanser dahil hastal\u0131klar\u0131n geli\u015fimini nas\u0131l etkiledi\u011fini ara\u015ft\u0131r\u0131yorlar. <\/span>Ara\u015ft\u0131rmas\u0131n\u0131n edindi\u011fi i\u00e7g\u00f6r\u00fclerden biri, telomerlerin h\u00fccresel sa\u011fl\u0131\u011f\u0131 besledi\u011fi ve h\u00fccrelerin b\u00fcy\u00fcmesine izin verdi\u011fidir. <\/span>Phoenix yak\u0131nlar\u0131ndaki hastanemizde resepsiyonist ve birinci basamak hekimi olan Stephen Lynch, “DNA’n\u0131n ucundaki k\u00fc\u00e7\u00fck parmaklar gibiler” diyor. <\/span>\u201cH\u00fccreleri korur ve h\u00fccre b\u00f6l\u00fcnmesi s\u00fcrecinde h\u00fccrelerin DNA’daki hatalar\u0131 d\u00fczeltmesini sa\u011flar.<\/span><\/span><\/span><\/span><\/p>\n

Telomerler nedir?<\/span><\/span><\/h2>\n

Telomerler, ayakkab\u0131 ba\u011fc\u0131\u011f\u0131n\u0131n ucundaki y\u0131pranmay\u0131 \u00f6nleyen plastik veya metal u\u00e7lar olan akite benzetilmi\u015ftir. <\/span>\u0130plik hasar g\u00f6rd\u00fc\u011f\u00fcnde veya y\u0131prand\u0131\u011f\u0131nda ip kopmaya ba\u015flar. <\/span>Telomerler, her h\u00fccre b\u00f6l\u00fcnmesi veya replikasyonu ile k\u00fc\u00e7\u00fcl\u00fcr. <\/span>Ya\u015fland\u0131k\u00e7a, telomerler kromozomu koruyamayacak kadar k\u00fc\u00e7\u00fcl\u00fcr ve h\u00fccre hasar\u0131n\u0131n olu\u015fmas\u0131n\u0131 art\u0131k engelleyemez ve bu, kanser h\u00fccreleri i\u00e7in bir \u00fcreme alan\u0131 olu\u015fturabilir. <\/span>Amerika Kanser Tedavi Merkezlerinde t\u0131p ve bilim \u015fefi olan Murray Markman, \u201cKanser, ya\u015flanma ad\u0131 verilen evrimsel bir s\u00fcrecin sonucudur\u201d diyor. <\/span><\/span>\u00ae<\/span><\/span><\/sup> (CTCA). <\/span>“Bu, uzun y\u0131llar boyunca meydana gelen t\u00fcm h\u00fccre b\u00f6l\u00fcnmelerinin, kopyalar\u0131n\u0131n ve mutasyonlar\u0131n sonucudur.”<\/span><\/span><\/p>\n

\u00d6yleyse telomerler ya\u015fla birlikte k\u00fc\u00e7\u00fcl\u00fcyorsa ve ya\u015f \u00f6nemli bir kanser risk fakt\u00f6r\u00fcyse, daha uzun telomerler kanser riskini azalt\u0131r m\u0131? <\/span>Boston’daki Dana-Farber Kanser Enstit\u00fcs\u00fc’ndeki ara\u015ft\u0131rmac\u0131lar, cevab\u0131n evet olabilece\u011fine inan\u0131yorlar \u00e7\u00fcnk\u00fc telomer uzunlu\u011funun “ya\u015flanma oran\u0131n\u0131 ve ya\u015fa ba\u011fl\u0131 hastal\u0131klar\u0131n ba\u015flang\u0131c\u0131n\u0131 etkileyebilece\u011fini” varsay\u0131yorlar. <\/span>Bu arada, Houston’daki MD Anderson Kanser Merkezi’ndeki bilim adamlar\u0131, k\u0131sa telomerlerin kanser hastalar\u0131nda daha s\u0131k g\u00f6r\u00fcld\u00fc\u011f\u00fc sonucuna vard\u0131lar. <\/span>Ara\u015ft\u0131rmac\u0131lar, \u00e7e\u015fitli kanser te\u015fhisi konan d\u00fczinelerce hastada telomer uzunlu\u011funu inceledi. <\/span>Vard\u0131klar\u0131 sonu\u00e7: “Daha k\u0131sa telomerler, artan mesane, ba\u015f ve boyun, akci\u011fer ve b\u00f6brek h\u00fccre kanseri riski ile ili\u015fkili g\u00f6r\u00fcn\u00fcyor.”<\/span><\/span><\/p>\n

Telomer Ger\u00e7ekleri<\/span><\/span><\/h2>\n
    \n
  • Telomerler, insan kromozomlar\u0131n\u0131n u\u00e7lar\u0131nda bulunan DNA dizilerini kopyalar.<\/span><\/span><\/li>\n
  • Telomerler, DNA sarmal\u0131ndaki merdivenin basamaklar\u0131n\u0131 olu\u015fturan \u00f6zde\u015f n\u00fckleotit gruplar\u0131 olan baz \u00e7iftlerinden yap\u0131l\u0131r. <\/span>Telomerler 15.000 baz \u00e7iftine kadar uzunlukta olabilir.<\/span><\/span><\/li>\n
  • Bir h\u00fccre her b\u00f6l\u00fcnd\u00fc\u011f\u00fcnde, DNA’s\u0131 200’e kadar baz \u00e7iftini kaybeder. <\/span>Kaybedilen baz \u00e7iftlerinin say\u0131s\u0131, strese ve di\u011fer ya\u015fam tarz\u0131 etkilerine ba\u011fl\u0131 olabilir.<\/span><\/span><\/li>\n<\/ul>\n

    Nas\u0131l daha k\u0131sa telomerler ya\u015flanma, hastal\u0131k ve k\u00f6t\u00fc sa\u011fl\u0131kla ili\u015fkilendiriliyorsa, daha uzun telomerler de kanser riskini azaltabilecek daha sa\u011fl\u0131kl\u0131 bir ya\u015fam tarz\u0131yla ili\u015fkilendiriliyor. <\/span>Dr. Lynch, “Ara\u015ft\u0131rmalar, \u00e7ok yol kat eden insanlar\u0131n daha uzun telomerlere sahip olma e\u011filiminde oldu\u011funu g\u00f6steriyor” diyor. <\/span>“Egzersizin iyi oldu\u011funu ve sizi sa\u011fl\u0131kl\u0131 tuttu\u011funu biliyoruz. Belki bunun nedenlerinden biri telomerlerin DNA’n\u0131z\u0131 sa\u011fl\u0131kl\u0131 tutman\u0131za yard\u0131mc\u0131 olabilmesidir.” <\/span>California \u00dcniversitesi, San Francisco (UCSF) taraf\u0131ndan yap\u0131lan bir ara\u015ft\u0131rma, daha fazla egzersiz ve daha iyi bir diyet dahil olmak \u00fczere ya\u015fam tarz\u0131 de\u011fi\u015fikliklerinin telomerleri uzatabilece\u011fi sonucuna varm\u0131\u015ft\u0131r. <\/span>San Francisco California \u00dcniversitesi’nde klinik t\u0131p profes\u00f6r\u00fc olan yazar Dean Ornish, \u00e7al\u0131\u015fmayla ilgili bir makalede, “Bu bulgular, insanlar ya\u015fam tarzlar\u0131n\u0131 de\u011fi\u015ftirdi\u011finde telomerlerin uzayabilece\u011fini g\u00f6steriyor” diyor. <\/span>“<\/span><\/span><\/p>\n

    \u015ea\u015f\u0131rt\u0131c\u0131 olmayan bir \u015fekilde, bu bilim, telomerlerin ya\u015flanmay\u0131 tersine \u00e7evirmek i\u00e7in manip\u00fcle edilebilece\u011fi teorilerine yol a\u00e7t\u0131. <\/span><\/span>Harvard Gazette’de<\/span><\/span><\/em> yay\u0131nlanan 2010 tarihli bir makalede <\/span>bilim adamlar\u0131, farelerde ya\u015flanma s\u00fcrecini tersine \u00e7evirmek i\u00e7in telomerleri besleyen enzim olan telomeraz kulland\u0131klar\u0131n\u0131 s\u00f6ylediler. <\/span>Ara\u015ft\u0131rmac\u0131lara g\u00f6re, enzim verildi\u011finde fareler \u00f6nemli \u00f6l\u00e7\u00fcde daha sa\u011fl\u0131kl\u0131 hale geldi. <\/span>Organlar yenilendi, beyin h\u00fccreleri daha aktif hale geldi ve erkekler do\u011furganl\u0131klar\u0131n\u0131 yeniden kazand\u0131. <\/span>Harvard ara\u015ft\u0131rmac\u0131s\u0131 ve MD Anderson’\u0131n eski ba\u015fkan\u0131 Ronald DePinho, \u201cBizi ger\u00e7ekten \u015fa\u015f\u0131rtan \u015fey, bu hayvanlar \u00fczerinde g\u00f6rd\u00fc\u011f\u00fcm\u00fcz etkilerin dramatik bir \u015fekilde tersine \u00e7evrilmesiydi\u201d diyor.<\/span><\/span><\/p>\n

    Telomerleri beslemenin yan\u0131 s\u0131ra telomeraz, embriyonik h\u00fccreler ve aktif ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccreleri de dahil olmak \u00fczere bir\u00e7ok h\u00fccrede bulunabilen g\u00fc\u00e7l\u00fc bir enzimdir. <\/span>Ancak bu enzim kanser h\u00fccrelerinde de bulunur ve ya\u015fa ba\u011fl\u0131 kanseri \u00f6nlemek yerine t\u00fcm\u00f6rleri uyarabilece\u011fi endi\u015felerini art\u0131rmaktad\u0131r. <\/span>Telomerlerin sa\u011fl\u0131kl\u0131 ya\u015famdaki rol\u00fcn\u00fc destekleyen ara\u015ft\u0131rmalara ve kanser ve di\u011fer hastal\u0131klardaki rollerini ara\u015ft\u0131ran \u00e7ok say\u0131da klinik ara\u015ft\u0131rmaya ra\u011fmen, telomer ara\u015ft\u0131rmalar\u0131n\u0131n \u00f6l\u00fcms\u00fczl\u00fc\u011fe veya mucizevi tedavilere yol a\u00e7aca\u011f\u0131na dair hi\u00e7bir kan\u0131t bulunamad\u0131. <\/span>Bug\u00fcne kadar, Gen\u00e7lik \u00c7e\u015fmesi belirsizli\u011fini koruyor. <\/span>Dr. Lynch, “Sonsuza kadar dayanacak \u015fekilde tasarlanmad\u0131k” diyor. <\/span>“Baba Zaman\u0131 hala yenilmez.”<\/span><\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

    K\u00fc\u00e7\u00fck kromozom u\u00e7lar\u0131, sizden b\u00fcy\u00fck oldu\u011funuzu g\u00f6sterir. WHepimiz kronolojik olarak ka\u00e7 ya\u015f\u0131nda oldu\u011fumuzu biliyoruz. Ama biyolojik olarak ka\u00e7 ya\u015f\u0131nda oldu\u011fumuzu biliyor muyuz? Herkes farkl\u0131 oranlarda ya\u015flan\u0131r. Ya\u015fam tarz\u0131, genetik, stres ve di\u011fer fakt\u00f6rler, g\u00f6r\u00fcnd\u00fc\u011f\u00fcm\u00fczden daha gen\u00e7 kalmam\u0131za veya ya\u015f\u0131m\u0131z\u0131n \u00f6tesinde ya\u015flanmam\u0131za katk\u0131da bulunur. \u0130\u00e7 ya\u015flanma s\u00fcrecinin a\u00e7\u0131klay\u0131c\u0131 bir i\u015fareti, her birimizin derinliklerinde, her kromozomun ucundaki …<\/p>\n","protected":false},"author":1,"featured_media":21736,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-22917","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-tr"],"yoast_head":"\nK\u00fc\u00e7\u00fck kromozom u\u00e7lar\u0131, sizden b\u00fcy\u00fck oldu\u011funuzu g\u00f6sterir. - zdmaa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zdmaa.com\/tr\/tiny-chromosome-tips-say-youre-older-than-you-are\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"K\u00fc\u00e7\u00fck kromozom u\u00e7lar\u0131, sizden b\u00fcy\u00fck oldu\u011funuzu g\u00f6sterir. - zdmaa\" \/>\n<meta property=\"og:description\" content=\"K\u00fc\u00e7\u00fck kromozom u\u00e7lar\u0131, sizden b\u00fcy\u00fck oldu\u011funuzu g\u00f6sterir. WHepimiz kronolojik olarak ka\u00e7 ya\u015f\u0131nda oldu\u011fumuzu biliyoruz. Ama biyolojik olarak ka\u00e7 ya\u015f\u0131nda oldu\u011fumuzu biliyor muyuz? Herkes farkl\u0131 oranlarda ya\u015flan\u0131r. Ya\u015fam tarz\u0131, genetik, stres ve di\u011fer fakt\u00f6rler, g\u00f6r\u00fcnd\u00fc\u011f\u00fcm\u00fczden daha gen\u00e7 kalmam\u0131za veya ya\u015f\u0131m\u0131z\u0131n \u00f6tesinde ya\u015flanmam\u0131za katk\u0131da bulunur. \u0130\u00e7 ya\u015flanma s\u00fcrecinin a\u00e7\u0131klay\u0131c\u0131 bir i\u015fareti, her birimizin derinliklerinde, her kromozomun ucundaki …\" \/>\n<meta property=\"og:url\" content=\"https:\/\/zdmaa.com\/tr\/tiny-chromosome-tips-say-youre-older-than-you-are\/\" \/>\n<meta property=\"og:site_name\" content=\"zdmaa\" \/>\n<meta property=\"article:published_time\" content=\"2022-01-11T14:11:21+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-01-12T01:10:26+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/zdmaa.com\/wp-content\/uploads\/2022\/01\/mitosis-gbaf4d2bb2_640.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"640\" \/>\n\t<meta property=\"og:image:height\" content=\"360\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Yazan:\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tahmini okuma s\u00fcresi\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 dakika\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/zdmaa.com\/tr\/tiny-chromosome-tips-say-youre-older-than-you-are\/\",\"url\":\"https:\/\/zdmaa.com\/tr\/tiny-chromosome-tips-say-youre-older-than-you-are\/\",\"name\":\"K\u00fc\u00e7\u00fck kromozom u\u00e7lar\u0131, sizden b\u00fcy\u00fck oldu\u011funuzu g\u00f6sterir. - 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WHepimiz kronolojik olarak ka\u00e7 ya\u015f\u0131nda oldu\u011fumuzu biliyoruz. Ama biyolojik olarak ka\u00e7 ya\u015f\u0131nda oldu\u011fumuzu biliyor muyuz? Herkes farkl\u0131 oranlarda ya\u015flan\u0131r. 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