{"id":23938,"date":"2022-01-12T20:20:54","date_gmt":"2022-01-12T17:20:54","guid":{"rendered":"https:\/\/zdmaa.com\/how-does-cancer-do-that-sizing-up-cells-and-their-shapes\/"},"modified":"2022-01-12T23:19:08","modified_gmt":"2022-01-12T20:19:08","slug":"how-does-cancer-do-that-sizing-up-cells-and-their-shapes","status":"publish","type":"post","link":"https:\/\/zdmaa.com\/tr\/how-does-cancer-do-that-sizing-up-cells-and-their-shapes\/","title":{"rendered":"Kanser bunu nas\u0131l yap\u0131yor? H\u00fccre boyutland\u0131rma ve \u015fekiller"},"content":{"rendered":"

Kanser bunu nas\u0131l yap\u0131yor? <\/span><\/span><\/span>H\u00fccre boyutland\u0131rma ve \u015fekiller<\/span><\/span><\/span><\/span><\/p>\n

\n

H<\/span><\/span><\/span> \u0130nsan h\u00fccreleri, genellikle h\u00fccre i\u015flevine dair ipu\u00e7lar\u0131 sa\u011flayan bir\u00e7ok boyut ve \u015fekilde gelir. <\/span>\u00d6rne\u011fin makrofaj ad\u0131 verilen ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccreleri, bakteri, vir\u00fcs veya di\u011fer h\u00fccrelere ula\u015fan ve onlar\u0131 t\u00fcketen uzun dokuna\u00e7lara sahiptir. <\/span>N\u00f6ronlar daha iyi ileti\u015fim kurmak ve bilgi iletmek i\u00e7in \u00e7o\u011fal\u0131r. <\/span>Deriyi ve organlar\u0131 kaplayan skuam\u00f6z h\u00fccreler, bal\u0131k pullar\u0131 gibi ince ve d\u00fczd\u00fcr. <\/span>Doktorlar ayr\u0131ca, k\u0131rm\u0131z\u0131 kan h\u00fccrelerini bozan orak h\u00fccreli anemi gibi hastal\u0131klar\u0131n te\u015fhisine yard\u0131mc\u0131 olmak i\u00e7in h\u00fccre formlar\u0131n\u0131 kullan\u0131r. <\/span>Konu kanser oldu\u011funda, h\u00fccrelerin boyutu veya \u015fekli, hastal\u0131\u011f\u0131n tipini ve evresini te\u015fhis etmeye yard\u0131mc\u0131 olmak i\u00e7in kritik olabilir.<\/span><\/span><\/p>\n

Fernando Yu, “Genel olarak kanser h\u00fccrelerinin normal h\u00fccrelerden daha b\u00fcy\u00fck \u00e7ekirdekleri vard\u0131r” diyor. <\/span>“Bu, esas olarak, kanserin geli\u015fmesine yol a\u00e7an DNA’daki de\u011fi\u015fikliklerden kaynaklanmaktad\u0131r. DNA’daki bu de\u011fi\u015fiklik, h\u00fccrelere hiperpigmentasyon ad\u0131 verilen bir \u00f6zellik verir, bu da h\u00fccrelerin normal h\u00fccrelerden daha koyu g\u00f6r\u00fcnmesi anlam\u0131na gelir ve polimorflar, yani farkl\u0131 \u015fekil ve b\u00fcy\u00fckl\u00fckteki h\u00fccreler anlam\u0131na gelir.” “<\/span><\/span><\/p>\n

“\u00d6nemli olan sadece \u015fekil de\u011fil, h\u00fccre say\u0131s\u0131 ve \u015fekillerin \u00e7e\u015fitlili\u011fidir. \u00c7o\u011fu y\u00fcksek dereceli III kanserde, \u00f6rne\u011fin b\u00fcy\u00fck, yuvarlak, kare, \u00fc\u00e7gen h\u00fccreler g\u00f6r\u00fcl\u00fcr. \u00e7e\u015fitli \u015fekil ve boyutlarda.\u201d <\/span><\/span>– Fernando Yu Garcia, patolog<\/span><\/span><\/em><\/p><\/blockquote>\n

Kanser h\u00fccreleri aras\u0131nda ayr\u0131m yap\u0131n<\/span><\/span><\/h2>\n

Dr. Garcia, mutasyona u\u011fram\u0131\u015f ve anormal h\u00fccrelerin bu kaotik koleksiyonunun, patologlar\u0131n bir doku \u00f6rne\u011finin kanserli olup olmad\u0131\u011f\u0131n\u0131 belirlemesine izin verebilece\u011fini s\u00f6yl\u00fcyor. <\/span>“\u00d6nemli olan sadece \u015fekil de\u011fil, h\u00fccre say\u0131s\u0131 ve \u015fekillerin \u00e7e\u015fitlili\u011fidir” diyor. <\/span>“\u00d6rne\u011fin, y\u00fcksek dereceli III kanserlerin \u00e7o\u011funda b\u00fcy\u00fck, yuvarlak, kare, \u00fc\u00e7gen h\u00fccreler g\u00f6r\u00fcrs\u00fcn\u00fcz. \u00c7e\u015fitli \u015fekil ve boyutlara bak\u0131yorsunuz.” <\/span>Bilim adamlar\u0131 ayr\u0131ca bu h\u00fccre \u015fekillerinin size baz\u0131 kanserlerdeki potansiyel genetik mutasyonlar hakk\u0131nda neler s\u00f6yleyebilece\u011fini ve bu \u015fekillerin kanserin v\u00fccutta nas\u0131l dola\u015faca\u011f\u0131n\u0131 tahmin etmeye yard\u0131mc\u0131 olup olmayaca\u011f\u0131n\u0131 ara\u015ft\u0131r\u0131yorlar.<\/span><\/span><\/p>\n

H\u00fccre \u015fekli ayr\u0131ca spesifik kanser tipini belirlemeye yard\u0131mc\u0131 olabilir. <\/span>\u00d6rne\u011fin, h\u00fccrelerin \u015fekli, bir hastan\u0131n lenfomas\u0131n\u0131n Hodgkin mi yoksa Hodgkin olmayan m\u0131 oldu\u011funu belirlemeye yard\u0131mc\u0131 olur. <\/span>Hodgkin lenfoma hastalar\u0131nda, Reed-Sternberg h\u00fccreleri ad\u0131 verilen, bayku\u015f g\u00f6zleri \u015feklinde olan ve Hodgkin d\u0131\u015f\u0131 lenfoma hastalar\u0131nda bulunmayan bin\u00fckleer h\u00fccrelerde geni\u015fleme vard\u0131r. <\/span>Glioblastoma ad\u0131 verilen beyin t\u00fcm\u00f6rleri, y\u0131ld\u0131z h\u00fccreleri ad\u0131 verilen y\u0131ld\u0131z \u015feklindeki h\u00fccrelerde ba\u015flad\u0131klar\u0131 i\u00e7in astrositom olarak da bilinirler.<\/span><\/span><\/p>\n

H\u00fccresel veri<\/span><\/span><\/h2>\n
    \n
  • Mycoplasma gallisepticum’un 0.0001 mm boyutunda d\u00fcnyan\u0131n en k\u00fc\u00e7\u00fck h\u00fccresi oldu\u011funa inan\u0131l\u0131yor. <\/span>Kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, bir tuz tanesi yakla\u015f\u0131k 5 milimetre b\u00fcy\u00fckl\u00fc\u011f\u00fcndedir ve tavuklarda solunum s\u0131k\u0131nt\u0131s\u0131na neden olur.<\/span><\/span><\/li>\n
  • En b\u00fcy\u00fck h\u00fccre olan Caulerpa taxifolia, su yosunlar\u0131nda bulunur ve uzunlu\u011fu 30 cm’ye kadar \u00e7\u0131kabilir.<\/span><\/span><\/li>\n
  • \u0130nsanlardaki en b\u00fcy\u00fck h\u00fccre yumurtad\u0131r, insan yumurtas\u0131d\u0131r. <\/span>En k\u00fc\u00e7\u00fck insan h\u00fccresi spermdir.<\/span><\/span><\/li>\n
  • \u0130nsan v\u00fccudundaki en uzun h\u00fccreler n\u00f6ronlard\u0131r.<\/span><\/span><\/li>\n<\/ul>\n

    Son y\u0131llarda, birka\u00e7 klinik \u00e7al\u0131\u015fma, h\u00fccre \u015fekillerinin, doktorlar\u0131n kanserin uzak organlara yay\u0131lma veya metastaz yapma olas\u0131l\u0131\u011f\u0131n\u0131 tahmin etmelerine yard\u0131mc\u0131 olup olamayaca\u011f\u0131n\u0131 inceledi. <\/span>Bilgisayar algoritmalar\u0131n\u0131 ve dijital g\u00f6r\u00fcnt\u00fc analizini kullanan Dr. Garcia ve Drexel \u00dcniversitesi’nden bir ara\u015ft\u0131rma ekibi, baz\u0131 hastalar\u0131n meme kanserinin lenf bezlerine metastaz yap\u0131p yapmad\u0131\u011f\u0131n\u0131 belirledi. <\/span>Dr. Garcia, “Slayttaki h\u00fccrelere bakarak ve dijital g\u00f6r\u00fcnt\u00fcy\u00fc bir algoritma arac\u0131l\u0131\u011f\u0131yla \u00e7al\u0131\u015ft\u0131rarak lenf nodu metastazlar\u0131n\u0131 tahmin edebiliriz” diyor. <\/span>“Di\u011fer fakt\u00f6rlerin yan\u0131 s\u0131ra h\u00fccrelerin \u015fekline, birbirleriyle ili\u015fkilerine ve normal yap\u0131larla etkile\u015fime bak\u0131yoruz.”<\/span><\/span><\/p>\n

    Cancer Research UK’deki bilim adamlar\u0131 ayr\u0131ca kanser h\u00fccrelerinin \u015fekillerinin genetik mutasyonlarla ba\u011flant\u0131l\u0131 olup olmad\u0131\u011f\u0131n\u0131 ara\u015ft\u0131r\u0131yorlar. <\/span>Ara\u015ft\u0131rmac\u0131lar, farelerde melanom h\u00fccrelerini inceleyerek, h\u00fccrelerin \u015feklini etkileyebilece\u011fine inand\u0131klar\u0131 birka\u00e7 geni tan\u0131mlayabildiler. <\/span>Bunlar\u0131n aras\u0131nda, kapat\u0131ld\u0131\u011f\u0131nda kanser h\u00fccrelerinin yuvarlak veya dikd\u00f6rtgen hale gelmesini sa\u011flayan PTEN adl\u0131 bir gen vard\u0131r – yay\u0131lmalar\u0131na yard\u0131mc\u0131 olmak i\u00e7in m\u00fckemmel \u015fekiller. <\/span>Yuvarlak h\u00fccreler kan dola\u015f\u0131m\u0131nda daha kolay hareket eder; <\/span>Uzat\u0131lm\u0131\u015f h\u00fccreler kemik ili\u011fine daha iyi n\u00fcfuz edebilir veya organlar\u0131 istila edebilir.<\/span><\/span><\/p>\n

    Doktora ba\u015f ara\u015ft\u0131rmac\u0131 Chris Bacall, h\u00fccre \u015fekilleri ve \u015fekillerin kanser h\u00fccrelerinin davran\u0131\u015f\u0131n\u0131 nas\u0131l belirledi\u011fine dahil olan genler hakk\u0131nda daha fazla bilgi edinmenin sonunda yeni tedavilere yol a\u00e7abilece\u011fini s\u00f6yl\u00fcyor. <\/span>Dr. Bacall, “Kanserin \u015feklini de\u011fi\u015ftirerek daha az agresif hale getirmek, di\u011fer tedavilerde etkili olabilir ve onlara daha iyi \u00e7al\u0131\u015fma \u015fans\u0131 verebilir” diyor.<\/span><\/span><\/p>\n

    \u0130yi huylu ve k\u00f6t\u00fc huylu t\u00fcm\u00f6rler aras\u0131ndaki fark hakk\u0131nda daha fazla bilgi edinin.<\/span><\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

    Kanser bunu nas\u0131l yap\u0131yor? H\u00fccre boyutland\u0131rma ve \u015fekiller H \u0130nsan h\u00fccreleri, genellikle h\u00fccre i\u015flevine dair ipu\u00e7lar\u0131 sa\u011flayan bir\u00e7ok boyut ve \u015fekilde gelir. \u00d6rne\u011fin makrofaj ad\u0131 verilen ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccreleri, bakteri, vir\u00fcs veya di\u011fer h\u00fccrelere ula\u015fan ve onlar\u0131 t\u00fcketen uzun dokuna\u00e7lara sahiptir. N\u00f6ronlar daha iyi ileti\u015fim kurmak ve bilgi iletmek i\u00e7in \u00e7o\u011fal\u0131r. Deriyi ve organlar\u0131 kaplayan skuam\u00f6z …<\/p>\n","protected":false},"author":1,"featured_media":23551,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-23938","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-tr"],"yoast_head":"\nKanser bunu nas\u0131l yap\u0131yor? 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