{"id":23974,"date":"2022-01-12T20:14:47","date_gmt":"2022-01-12T17:14:47","guid":{"rendered":"https:\/\/zdmaa.com\/five-things-you-should-know-about-car-t-cell-therapy\/"},"modified":"2022-01-12T23:36:52","modified_gmt":"2022-01-12T20:36:52","slug":"five-things-you-should-know-about-car-t-cell-therapy","status":"publish","type":"post","link":"https:\/\/zdmaa.com\/tr\/five-things-you-should-know-about-car-t-cell-therapy\/","title":{"rendered":"CAR-T-h\u00fccre tedavisi hakk\u0131nda bilmeniz gereken be\u015f \u015fey"},"content":{"rendered":"

CAR-T-h\u00fccre tedavisi hakk\u0131nda bilmeniz gereken be\u015f \u015fey<\/span><\/span><\/span><\/span><\/p>\n

\n

W<\/span><\/span><\/span> ABD G\u0131da ve \u0130la\u00e7 Dairesi (FDA) ge\u00e7en y\u0131l l\u00f6semi i\u00e7in yeni bir tedaviyi onaylad\u0131\u011f\u0131nda, Emily Whitehead ad\u0131nda 12 ya\u015f\u0131ndaki bir k\u0131z \u00f6nemli duyuruya tan\u0131k olmak i\u00e7in haz\u0131rd\u0131. <\/span>Alt\u0131 y\u0131l \u00f6nce, ailesi onu CAR T-h\u00fccre tedavisi ad\u0131 verilen yeni bir kanser tedavisinin klinik denemesine kaydettirdi\u011finde, Emily \u00f6l\u00fcm\u00fcn e\u015fi\u011findeydi. <\/span>Ortaya \u00e7\u0131kan bu imm\u00fcnoterapi bi\u00e7imi, kansere sald\u0131rmak i\u00e7in hastan\u0131n kendi yeniden tasarlanm\u0131\u015f h\u00fccrelerini kullan\u0131r. <\/span>Bug\u00fcn, CAR-T-h\u00fccre tedavisi alan ilk pediatrik hasta olan Emily, o zamandan beri tedavi g\u00f6ren d\u00fczinelerce hastal\u0131k kan\u0131t\u0131na sahip de\u011fil. <\/span>Penn Medicine’de onkolog olan Stephen Schuster, \u201c\u00dc\u00e7 veya d\u00f6rt y\u0131l \u00f6nce hayatta kalmaya \u00e7al\u0131\u015fmak i\u00e7in zekam\u0131z\u0131n s\u0131n\u0131r\u0131nda olan hastalar\u0131 kurtar\u0131yoruz\u201d dedi. <\/span>CAR T-h\u00fccre tedavisi \u00fczerine <\/span><\/span>Washington Post<\/span><\/span><\/em> .<\/span><\/span><\/p>\n

Bununla birlikte, iyimserli\u011fe ra\u011fmen, CAR T-h\u00fccre tedavisinin \u00f6nemli dezavantajlar\u0131 oldu\u011funu bilmek \u00f6nemlidir: \u00e7o\u011fu hasta i\u00e7in mevcut de\u011fildir, onaylar\u0131 \u00e7ok s\u0131n\u0131rl\u0131d\u0131r ve genellikle baz\u0131 hastalarda ciddi yan etkilere neden olur.<\/span><\/span><\/p>\n

Bir\u00e7ok kanser tedavisi, h\u00fccrelerin kansere sald\u0131rmas\u0131n\u0131 sa\u011flayarak \u00e7al\u0131\u015f\u0131r. <\/span>CAR T h\u00fccre tedavisi, bir hastan\u0131n ba\u011f\u0131\u015f\u0131kl\u0131k fonksiyonu i\u00e7in gerekli olan beyaz kan h\u00fccreleri olan T h\u00fccrelerini \u00e7\u0131kar\u0131r, daha sonra bunlar\u0131 laboratuvarda de\u011fi\u015ftirir ve hastan\u0131n v\u00fccuduna geri d\u00f6nd\u00fcr\u00fcr. <\/span>Yeniden tasarlanan T h\u00fccreleri, kanser h\u00fccrelerini tan\u0131mak ve onlara sald\u0131rmak \u00fczere tasarlanm\u0131\u015ft\u0131r. <\/span>Amerikan Klinik Onkoloji Derne\u011fi (ASCO), tedaviyi 2018 i\u00e7in at\u0131l\u0131m olarak nitelendirdi. Asco, “Kanseri tedavi etmenin yeni ve benzersiz bir yolu olan CAR T-h\u00fccresi tedavisi, baz\u0131 tedavi edilemez hastal\u0131klar\u0131 olan \u00e7ocuklar ve yeti\u015fkinler i\u00e7in g\u00f6r\u00fcn\u00fcm\u00fc de\u011fi\u015ftirmeye haz\u0131rlan\u0131yor” dedi. Bir a\u00e7\u0131klamada. <\/span>kanserler”.<\/span><\/span><\/p>\n

CAR (kimerik antijen resept\u00f6r\u00fc), ad\u0131n\u0131 farkl\u0131 hayvanlar\u0131n par\u00e7alar\u0131ndan olu\u015fan efsanevi bir yarat\u0131k olan kimeradan alm\u0131\u015ft\u0131r: bir aslan ba\u015f\u0131 ve bir ke\u00e7i g\u00f6vdesi. <\/span>CAR T h\u00fccrelerinin adlar\u0131na uygun olarak y\u00fczeylerinde ek anahtar par\u00e7alar bulunur: kanser h\u00fccrelerine ba\u011flanmak ve onlar\u0131 \u00f6ld\u00fcrmek i\u00e7in tasarlanm\u0131\u015f sentetik h\u00fccre resept\u00f6rleri. <\/span>Phoenix yak\u0131nlar\u0131ndaki hastanemizde hematoloji ve imm\u00fcnoterapi t\u0131bbi direkt\u00f6r\u00fc ve bir onkolog ve hematolog olan Alan Tan, \u201cCAR T h\u00fccre tedavisinin potansiyeli konusunda \u00e7ok heyecanl\u0131y\u0131m\u201d diyor. <\/span>“Bu, gelecekte ka\u00e7 kanserin tedavi edilece\u011fi konusunda \u00f6nemli bir kilometre ta\u015f\u0131d\u0131r.”<\/span><\/span><\/p>\n

“CAR-T h\u00fccre tedavisinin potansiyeli konusunda \u00e7ok heyecanl\u0131y\u0131m. Bu, gelecekte bir\u00e7ok kanseri nas\u0131l tedavi edece\u011fimiz konusunda \u00f6nemli bir kilometre ta\u015f\u0131.” <\/span><\/span>– Alan Tan, onkolog ve hematolog<\/span><\/span><\/em><\/p><\/blockquote>\n

CAR-T h\u00fccre tedavisi hakk\u0131nda bilmeniz gereken be\u015f \u015fey:<\/span><\/span><\/p>\n

Sadece az say\u0131da hastay\u0131 tedavi etmek i\u00e7in onaylanm\u0131\u015ft\u0131r.<\/span><\/span><\/h2>\n

Tedavi \u015fu ana kadar sadece iki kanser t\u00fcr\u00fcn\u00fc tedavi etmek i\u00e7in onayland\u0131: l\u00f6semi ve Hodgkin d\u0131\u015f\u0131 lenfoma. <\/span>Ve her iki ba\u011f\u0131ml\u0131l\u0131k da tedavi g\u00f6rebilecek hasta t\u00fcrlerini \u00f6nemli \u00f6l\u00e7\u00fcde s\u0131n\u0131rlar:<\/span><\/span><\/p>\n

    \n
  • Tisagenlecleucel<\/span><\/span><\/strong> (Kimraa <\/span><\/span>\u00ae<\/span><\/span><\/sup> etti edilmi\u015f <\/span>olarak onaylanan bir <\/span>kanser i\u00e7in tedavi se\u00e7ene\u011fi , <\/span>akut lenfoblastik l\u00f6semi (ALL) enfekte ya\u015fl\u0131 hastalarda 25 y\u0131l veya daha k\u0131sa s\u00fcrede sahip <\/span>tekrarlayan kanser ya da kim tedaviye diren\u00e7li hastal\u0131k var. G\u00f6re g\u00f6re <\/span>Ulusal Kanser Enstit\u00fcs\u00fc, 50’den fazla y\u00fczde T\u00fcm yeni ALL vakalar\u0131n\u0131n tamam\u0131 20 ya\u015f\u0131ndan k\u00fc\u00e7\u00fck hastalarda ortaya \u00e7\u0131kar.<\/span><\/span><\/li>\n
  • Oksikaptagen-sel\u00fclozil<\/span><\/span><\/strong> (evet, mesaj <\/span><\/span>\u00ae<\/span><\/span><\/sup> ) Hodgkin d\u0131\u015f\u0131 b\u00fcy\u00fck B h\u00fccreli lenfomal\u0131 yeti\u015fkin hastalar i\u00e7in ve yaln\u0131zca kanserin geri gelmesi veya hastal\u0131klar\u0131n\u0131n en az iki tedaviden sonra yan\u0131t vermemesi durumunda bir tedavi se\u00e7ene\u011fi olarak.<\/span><\/span><\/li>\n<\/ul>\n

    Kan kanserleri i\u00e7in en iyi \u015fekilde \u00e7al\u0131\u015f\u0131yor gibi g\u00f6r\u00fcn\u00fcyor.<\/span><\/span><\/h2>\n

    CAR T-h\u00fccre tedavisi yaln\u0131zca l\u00f6semiler i\u00e7in onaylanm\u0131\u015ft\u0131r ve kat\u0131 t\u00fcm\u00f6rlerdeki performans\u0131n\u0131 \u00f6l\u00e7en klinik deneyler cesaret verici olmam\u0131\u015ft\u0131r. <\/span>CAR T h\u00fccreleri, belirli bir B h\u00fccre tipini (enfeksiyonla sava\u015fan antikorlar \u00fcreten beyaz kan h\u00fccreleri) hedefleyerek l\u00f6semiyi tedavi eder. <\/span>Ancak bir\u00e7ok kat\u0131 t\u00fcm\u00f6r, ila\u00e7lar\u0131n bir ba\u011f\u0131\u015f\u0131kl\u0131k tepkisi ortaya \u00e7\u0131karmak i\u00e7in hedeflemeye \u00e7al\u0131\u015fabilece\u011fi \u00e7oklu gen mutasyonlar\u0131na sahiptir ve t\u00fcm\u00f6r b\u00fcy\u00fcmesini y\u00f6nlendiren tek bir hedef belirlemek zordur. <\/span>Ek olarak, baz\u0131 kat\u0131 t\u00fcm\u00f6rler, y\u0131k\u0131c\u0131 davran\u0131\u015flar sergilemek i\u00e7in ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccrelerini toplayarak t\u00fcm\u00f6r\u00fc tedaviye daha diren\u00e7li hale getirir. <\/span>“Kat\u0131 t\u00fcm\u00f6rlerle ilgili zorluk, neyi hedefliyor ve bu hedefin T h\u00fccresine nas\u0131l programland\u0131\u011f\u0131?” <\/span>Dr. Tan, “Bu biraz zaman alacak.”<\/span><\/span><\/p>\n

    CAR T h\u00fccre tedavisi ciddi yan etkilere neden olabilir.<\/span><\/span><\/h2>\n

    CAR T h\u00fccre tedavisinin yan etkileri, \u00f6zellikle sitokin sal\u0131n\u0131m sendromu (CRS) olarak bilinen bir durum, ya\u015fam\u0131 tehdit edebilir. <\/span>Sitokinler, ba\u011f\u0131\u015f\u0131kl\u0131k sistemini d\u00fczenlemeye yard\u0131mc\u0131 olan proteinlerdir. <\/span>Baz\u0131 durumlarda, CAR T-h\u00fccre tedavisi hastalar\u0131, sa\u011fl\u0131kl\u0131 h\u00fccrelere ve dokulara sald\u0131rmaya ba\u015flayan ve grip benzeri semptomlar, y\u00fcksek ate\u015f, ya\u015fam\u0131 tehdit eden n\u00f6rolojik yan etkiler ve di\u011fer ciddi durumlarla sonu\u00e7lanan sitokinler taraf\u0131ndan bo\u011fulur. <\/span>ABD G\u0131da ve \u0130la\u00e7 Dairesi (FDA), CAR T-h\u00fccre tedavisi kullanan hastanelerin CRS’yi tan\u0131mak ve y\u00f6netmek i\u00e7in sertifikal\u0131 ve e\u011fitimli personele sahip olmas\u0131n\u0131 \u015fart ko\u015far. <\/span>CAR T h\u00fccreleri, baz\u0131 hastalarda enfeksiyon riskini art\u0131rarak sa\u011fl\u0131kl\u0131 B h\u00fccrelerine de sald\u0131rabilir.<\/span><\/span><\/p>\n

    Tam tedaviyi tamamlamak haftalar s\u00fcrer.<\/span><\/span><\/h2>\n

    CAR-T h\u00fccrelerinin \u00fcretim s\u00fcreci \u00e7ok karma\u015f\u0131kt\u0131r. <\/span>T h\u00fccreleri kan dola\u015f\u0131m\u0131ndan \u00e7\u0131kar\u0131ld\u0131ktan sonra dondurulur ve bir laboratuvara g\u00f6nderilir. <\/span>Orada, T h\u00fccreleri i\u015flenir, yeniden tasarlan\u0131r, \u00e7o\u011falt\u0131l\u0131r, tekrar dondurulur ve ard\u0131ndan hastaya yeniden reddedilir. <\/span>Ba\u015ftan sona, s\u00fcre\u00e7 \u00fc\u00e7 hafta kadar s\u00fcrebilir. <\/span>S\u00fcrecin karma\u015f\u0131kl\u0131\u011f\u0131, tedavinin kullan\u0131labilirli\u011fini s\u0131n\u0131rlad\u0131 ve daha fazla hasta i\u00e7in kullan\u0131labilir hale getirmek i\u00e7in daha b\u00fcy\u00fck \u00f6l\u00e7ekte tekrarlan\u0131p uygulanamayaca\u011f\u0131na dair sorular\u0131 g\u00fcndeme getirdi.<\/span><\/span><\/p>\n

    CAR T h\u00fccreleri sonsuza kadar \u00e7al\u0131\u015facak \u015fekilde tasarlanm\u0131\u015ft\u0131r.<\/span><\/span><\/h2>\n

    T h\u00fccreleri zararl\u0131 h\u00fccrelere veya vir\u00fcslere sald\u0131rd\u0131\u011f\u0131nda, tekrar sald\u0131rd\u0131klar\u0131nda onlar\u0131 hat\u0131rlamaya programlanm\u0131\u015ft\u0131r. <\/span>CAR T h\u00fccreleri de farkl\u0131 de\u011fil, e\u011fer s\u00fcre\u00e7 d\u00fczg\u00fcn \u00e7al\u0131\u015f\u0131yorsa, hastan\u0131n \u00f6mr\u00fc boyunca 7\/24 g\u00f6rev ba\u015f\u0131nda olmalar\u0131 gerekir. <\/span>Teoride, kanser h\u00fccreleri yeniden ortaya \u00e7\u0131karsa, CAR T h\u00fccreleri, hastan\u0131n bilgisi olmadan bile onlar\u0131 tan\u0131yacak ve \u00f6ld\u00fcrecektir. <\/span>Tan, “CAR-T h\u00fccreleri, tek bir tedaviyle uzun s\u00fcreli etkilere sahip olacak \u015fekilde tasarlanm\u0131\u015ft\u0131r. Genel olarak konu\u015fursak, modifiye edilmi\u015f T h\u00fccreleri bir kez inf\u00fcze edildikten sonra v\u00fccudunuzda kal\u0131rlar. Bu, ‘canl\u0131 bir ilaca’ benzer. hayat\u0131n\u0131n geri kalan\u0131 i\u00e7in v\u00fccudun.”<\/span><\/span><\/span><\/span><\/p>\n

    L\u00f6semi ve Hodgkin olmayan lenfoma hakk\u0131nda daha fazla bilgi edinin<\/span><\/span><\/span><\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

    CAR-T-h\u00fccre tedavisi hakk\u0131nda bilmeniz gereken be\u015f \u015fey W ABD G\u0131da ve \u0130la\u00e7 Dairesi (FDA) ge\u00e7en y\u0131l l\u00f6semi i\u00e7in yeni bir tedaviyi onaylad\u0131\u011f\u0131nda, Emily Whitehead ad\u0131nda 12 ya\u015f\u0131ndaki bir k\u0131z \u00f6nemli duyuruya tan\u0131k olmak i\u00e7in haz\u0131rd\u0131. Alt\u0131 y\u0131l \u00f6nce, ailesi onu CAR T-h\u00fccre tedavisi ad\u0131 verilen yeni bir kanser tedavisinin klinik denemesine kaydettirdi\u011finde, Emily \u00f6l\u00fcm\u00fcn e\u015fi\u011findeydi. …<\/p>\n","protected":false},"author":1,"featured_media":23533,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-23974","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-tr"],"yoast_head":"\nCAR-T-h\u00fccre tedavisi hakk\u0131nda bilmeniz gereken be\u015f \u015fey - zdmaa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zdmaa.com\/tr\/five-things-you-should-know-about-car-t-cell-therapy\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CAR-T-h\u00fccre tedavisi hakk\u0131nda bilmeniz gereken be\u015f \u015fey - zdmaa\" \/>\n<meta property=\"og:description\" content=\"CAR-T-h\u00fccre tedavisi hakk\u0131nda bilmeniz gereken be\u015f \u015fey W ABD G\u0131da ve \u0130la\u00e7 Dairesi (FDA) ge\u00e7en y\u0131l l\u00f6semi i\u00e7in yeni bir tedaviyi onaylad\u0131\u011f\u0131nda, Emily Whitehead ad\u0131nda 12 ya\u015f\u0131ndaki bir k\u0131z \u00f6nemli duyuruya tan\u0131k olmak i\u00e7in haz\u0131rd\u0131. 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