{"id":24014,"date":"2022-01-12T20:05:06","date_gmt":"2022-01-12T17:05:06","guid":{"rendered":"https:\/\/zdmaa.com\/fat-cells-may-hinder-chemotherapys-impact\/"},"modified":"2022-01-12T23:52:00","modified_gmt":"2022-01-12T20:52:00","slug":"fat-cells-may-hinder-chemotherapys-impact","status":"publish","type":"post","link":"https:\/\/zdmaa.com\/tr\/fat-cells-may-hinder-chemotherapys-impact\/","title":{"rendered":"Ya\u011f h\u00fccreleri kemoterapinin etkisini engelleyebilir"},"content":{"rendered":"

Ya\u011f h\u00fccreleri kemoterapinin etkisini engelleyebilir<\/span><\/span><\/span><\/span><\/p>\n

\n

Obezitenin kalp hastal\u0131\u011f\u0131 ve y\u00fcksek tansiyondan diyabet, uyku apnesi ve kansere kadar bir dizi sa\u011fl\u0131k sorununa yol a\u00e7mas\u0131 haber de\u011feri ta\u015f\u0131maz. <\/span>Ancak kanser hastalar\u0131 i\u00e7in yeni bir \u00e7al\u0131\u015fma, obezitenin hastal\u0131\u011f\u0131 tedavi etme \u00e7abalar\u0131na m\u00fcdahale ederek daha fazla t\u0131bbi komplikasyona neden olabilece\u011fini \u00f6ne s\u00fcr\u00fcyor. <\/span><\/span>Molecular Cancer Research’te<\/span><\/span><\/em> yay\u0131nlanan ara\u015ft\u0131rmadan elde edilen bulgulara at\u0131fta <\/span>bulunan Ulusal Kanser Enstit\u00fcs\u00fc’nden bir rapor, ya\u011f h\u00fccrelerinin kemoterapi ila\u00e7lar\u0131n\u0131n etkinli\u011fini nas\u0131l azaltabilece\u011fini g\u00f6steriyor. <\/span>NCI personeli, \u00e7al\u0131\u015fma hakk\u0131nda yak\u0131n tarihli bir blog yaz\u0131s\u0131nda, “Ara\u015ft\u0131rmac\u0131lar, ya\u011f h\u00fccrelerinin yayg\u0131n olarak kullan\u0131lan iki kemoterapi ilac\u0131n\u0131 emebildi\u011fini ve kimyasal olarak onlar\u0131 daha az toksik formlara ay\u0131rabildi\u011fini ve bu da ila\u00e7lar\u0131n baz\u0131 kanserlerde etkinli\u011fini azaltabilece\u011fini g\u00f6sterdi” diyor.<\/span><\/span><\/p>\n

Ara\u015ft\u0131rmaya g\u00f6re, “ila\u00e7lar\u0131n al\u0131nmas\u0131 ve par\u00e7alanmas\u0131 yoluyla, ya\u011f h\u00fccreleri, kemik ili\u011findeki veya v\u00fccudun ya\u011f h\u00fccrelerinin bol oldu\u011fu di\u011fer b\u00f6lgelerindeki kanser h\u00fccrelerini \u00e7evreleyen ortamdan ila\u00e7lar\u0131 \u00e7\u0131karabilir.” <\/span>“Bu bulgu, obezitenin neden farkl\u0131 kanser t\u00fcrlerinde daha k\u00f6t\u00fc sonu\u00e7larla ili\u015fkili oldu\u011funu a\u00e7\u0131klamaya yard\u0131mc\u0131 olabilir.” <\/span>\u00c7al\u0131\u015fman\u0131n ba\u015f yazar\u0131, ara\u015ft\u0131rman\u0131n, ya\u011f h\u00fccrelerinin “metabolize ve inaktive” olabilece\u011fine dair kan\u0131t sa\u011flayan ilk ki\u015fi gibi g\u00f6r\u00fcnd\u00fc\u011f\u00fcn\u00fc belirtiyor. <\/span>Terap\u00f6tik ila\u00e7 <\/span><\/span>numaras\u0131<\/span><\/span><\/em> .<\/span><\/span><\/p>\n

\u00c7al\u0131\u015fma \u00f6nceki bulgulara nas\u0131l katk\u0131da bulunuyor?<\/span><\/span><\/h2>\n

Doktorlar daha \u00f6nce akut lenfoblastik l\u00f6semili obez \u00e7ocuklar\u0131n obez olmayan muadillerine g\u00f6re tekrarlama olas\u0131l\u0131\u011f\u0131n\u0131n y\u00fczde 50 daha fazla oldu\u011funu belirtmi\u015fti. <\/span>Meme, kolon, yumurtal\u0131k ve prostat kanseri olan obez hastalar, obez olmayanlara g\u00f6re daha k\u00f6t\u00fcyd\u00fc. <\/span>Metro Atlanta’daki hastanemizde t\u0131bbi onkolog olan Damien Hansra, kemoterapi ila\u00e7lar\u0131n\u0131n kanser h\u00fccrelerinin b\u00f6l\u00fcnme yetene\u011fini etkileyerek \u00e7al\u0131\u015ft\u0131\u011f\u0131n\u0131 ve b\u00f6ylece t\u00fcm\u00f6rlerin b\u00fcy\u00fcy\u00fcp yay\u0131lmad\u0131\u011f\u0131n\u0131 a\u00e7\u0131kl\u0131yor. <\/span>Ancak ara\u015ft\u0131rmac\u0131lar, obezitenin, t\u00fcm\u00f6r\u00fcn mikro\u00e7evresini veya t\u00fcm\u00f6r h\u00fccresini \u00e7evreleyen ve besleyen h\u00fccreleri, molek\u00fclleri ve kan damarlar\u0131n\u0131 de\u011fi\u015ftirerek ila\u00e7lar\u0131n etkisini karma\u015f\u0131kla\u015ft\u0131rd\u0131\u011f\u0131n\u0131 ke\u015ffediyorlar. <\/span>Bu s\u00fcre\u00e7, obez hastalar i\u00e7in t\u00fcm\u00f6r b\u00fcy\u00fcmesine yol a\u00e7abilecek biyolojik bir ortam yarat\u0131r.<\/span><\/span><\/p>\n

Obezite, \u00e7e\u015fitli kanserlerle ba\u011flant\u0131l\u0131 olan iltihab\u0131 art\u0131r\u0131r. <\/span>2017’de yay\u0131nlanan bir Miami \u00dcniversitesi ara\u015ft\u0131rmas\u0131, “obezitenin, \u00f6zellikle menopoz sonras\u0131 kad\u0131nlarda meme kanseri riskinin artmas\u0131 ve her ya\u015ftan kad\u0131nda daha k\u00f6t\u00fc hastal\u0131k sonu\u00e7lar\u0131 ile ili\u015fkili oldu\u011funu” buldu.<\/span><\/span><\/p>\n

Fazla kilolu ve obez olan ki\u015filerin, baz\u0131 kanser riskini art\u0131ran kronik iltihaplanmaya neden olan t\u0131bbi durumlar\u0131 olma olas\u0131l\u0131\u011f\u0131 daha y\u00fcksektir. <\/span>L\u00f6semi \u00e7al\u0131\u015fmas\u0131nda ara\u015ft\u0131rmac\u0131lar, y\u00fcksek d\u00fczeyde belirli enzimler \u00fcreten ya\u011f h\u00fccrelerinin antrasiklinler olarak bilinen bir kemoterapi ila\u00e7 s\u0131n\u0131f\u0131n\u0131 par\u00e7alayabildi\u011fini buldular. <\/span>Bu enzimlerin baz\u0131lar\u0131, akut lenfoblastik l\u00f6semi tedavisi g\u00f6ren \u00e7ocuklar\u0131n kemik ili\u011findeki ya\u011f h\u00fccrelerinde bulunur. <\/span>Ara\u015ft\u0131rmaya g\u00f6re, belirli kanser \u00f6nleyici ila\u00e7lar\u0131n al\u0131m\u0131 veya konsantrasyonunun azalt\u0131lmas\u0131 “ilaca diren\u00e7li kanser h\u00fccrelerinin geli\u015fimine” katk\u0131da bulunabilir.<\/span><\/span><\/p>\n

\u00d6nlenebilir bir hastal\u0131k<\/span><\/span><\/h2>\n

Dr. Hansra, y\u0131llar i\u00e7inde, kardiyotoksisite (kemoterapi ila\u00e7lar\u0131n\u0131n neden oldu\u011fu kalp hasar\u0131) ile ilgili endi\u015feler nedeniyle obez kanser hastalar\u0131nda d\u00fc\u015f\u00fck doz verilmesinin tart\u0131\u015fmalara yol a\u00e7t\u0131\u011f\u0131n\u0131 s\u00f6yl\u00fcyor. <\/span>Ancak 2012’de Amerikan Klinik Onkoloji Derne\u011fi konuyu inceledikten sonra, \u00f6zellikle tedavi s\u00f6z konusu oldu\u011funda obez kanserli hastalar\u0131n tedavisi i\u00e7in kiloya ba\u011fl\u0131 toplam sitotoksik kemoterapi dozlar\u0131n\u0131n kullan\u0131lmas\u0131n\u0131 \u00f6nerdi. toksisite, kilo baz\u0131nda tam doz alan obez hastalarda k\u0131sa veya uzun vadeli art\u0131\u015flard\u0131r.<\/span><\/span><\/p>\n

Dr. Hensra, hastalar\u0131n\u0131 obezitenin ciddi sa\u011fl\u0131k riskleri konusunda e\u011fitme konusunda tutkulu.<\/span><\/span><\/p>\n

“Obezite \u00f6nlenebilir, poligenik sistemik inflamatuar bir hastal\u0131kt\u0131r”. <\/span><\/span>Damien Hansra, t\u0131bbi onkolog<\/span><\/span><\/em><\/p><\/blockquote>\n

\u201cBu, k\u00f6t\u00fc sa\u011fl\u0131\u011f\u0131n kesin bir i\u015fareti\u201d diyor. <\/span>“Obezite ile ili\u015fkili ana sendromlar kardiyovask\u00fcler hastal\u0131k, serebrovask\u00fcler hastal\u0131k (beyni, kan damarlar\u0131n\u0131 ve arterleri etkileyen), diyabet, y\u00fcksek kolesterol, y\u00fcksek tansiyon, b\u00f6brek rahats\u0131zl\u0131klar\u0131 ve kas-iskelet sistemi rahats\u0131zl\u0131klar\u0131d\u0131r ve bunlar\u0131n hepsi daha fazla ila\u00e7 almay\u0131 gerektirir. Kemoterapiyi ekleyin. zaten hasta bir hastaya hormonal tedavi ve\/veya radyoterapi ve bu bir hastal\u0131k f\u0131rt\u0131nas\u0131 olacak ve giderek daha fazla ters ila\u00e7 reaksiyonu g\u00f6receksiniz.<\/span><\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Ya\u011f h\u00fccreleri kemoterapinin etkisini engelleyebilir Obezitenin kalp hastal\u0131\u011f\u0131 ve y\u00fcksek tansiyondan diyabet, uyku apnesi ve kansere kadar bir dizi sa\u011fl\u0131k sorununa yol a\u00e7mas\u0131 haber de\u011feri ta\u015f\u0131maz. Ancak kanser hastalar\u0131 i\u00e7in yeni bir \u00e7al\u0131\u015fma, obezitenin hastal\u0131\u011f\u0131 tedavi etme \u00e7abalar\u0131na m\u00fcdahale ederek daha fazla t\u0131bbi komplikasyona neden olabilece\u011fini \u00f6ne s\u00fcr\u00fcyor. Molecular Cancer Research’te yay\u0131nlanan ara\u015ft\u0131rmadan elde edilen …<\/p>\n","protected":false},"author":1,"featured_media":23515,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-24014","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-tr"],"yoast_head":"\nYa\u011f h\u00fccreleri kemoterapinin etkisini engelleyebilir - zdmaa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zdmaa.com\/tr\/fat-cells-may-hinder-chemotherapys-impact\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ya\u011f h\u00fccreleri kemoterapinin etkisini engelleyebilir - zdmaa\" \/>\n<meta property=\"og:description\" content=\"Ya\u011f h\u00fccreleri kemoterapinin etkisini engelleyebilir Obezitenin kalp hastal\u0131\u011f\u0131 ve y\u00fcksek tansiyondan diyabet, uyku apnesi ve kansere kadar bir dizi sa\u011fl\u0131k sorununa yol a\u00e7mas\u0131 haber de\u011feri ta\u015f\u0131maz. 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Ancak kanser hastalar\u0131 i\u00e7in yeni bir \u00e7al\u0131\u015fma, obezitenin hastal\u0131\u011f\u0131 tedavi etme \u00e7abalar\u0131na m\u00fcdahale ederek daha fazla t\u0131bbi komplikasyona neden olabilece\u011fini \u00f6ne s\u00fcr\u00fcyor. 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