{"id":24315,"date":"2022-01-12T14:59:18","date_gmt":"2022-01-12T11:59:18","guid":{"rendered":"https:\/\/zdmaa.com\/hereditary-cancer-risks-ctca\/"},"modified":"2022-01-13T02:01:37","modified_gmt":"2022-01-12T23:01:37","slug":"hereditary-cancer-risks-ctca","status":"publish","type":"post","link":"https:\/\/zdmaa.com\/tr\/hereditary-cancer-risks-ctca\/","title":{"rendered":"Kal\u0131tsal kanser riski CTCA"},"content":{"rendered":"

Kal\u0131tsal kanser riski <\/span><\/span><\/span>CTCA<\/span><\/span><\/span><\/span><\/p>\n

\n

Kanser, gelecek olmad\u0131\u011f\u0131n\u0131 bilmek m\u00fcmk\u00fcn de\u011fildir ne zaman ve v\u00fccudun hangi k\u0131sm\u0131nda. <\/span>Ya\u015f, ya\u015fam tarz\u0131 se\u00e7imleri, \u00e7evresel maruziyet ve di\u011fer fakt\u00f6rlerle birlikte kanser riskleri artar, ancak bir\u00e7ok kanserin kesin nedenleri ve neden baz\u0131 insanlar\u0131 etkileyip di\u011ferlerini etkilemedi\u011fi bir s\u0131r olarak kal\u0131r. <\/span>\u00d6rne\u011fin, ya\u015fam boyu sigara i\u00e7en bir ki\u015fi asla hastal\u0131\u011fa yakalanmayabilirken, fiziksel olarak zinde olan baz\u0131 sigara i\u00e7meyenlerde g\u00f6r\u00fcl\u00fcr. <\/span>Ancak baz\u0131 insanlar i\u00e7in kanser riski, ya\u015fam tarz\u0131 kararlar\u0131 veya di\u011fer risk fakt\u00f6rleri nedeniyle de\u011fil, onkologda aileden ge\u00e7en bir genin neden oldu\u011fu kal\u0131tsal kanser sendromu olarak bilinen \u015feye sahip olduklar\u0131 i\u00e7in bilinen ve devam eden bir tehdittir. . <\/span>\u2014 Te\u015fhis g\u00f6z korkutucu olabilir ve m\u00fcdahale i\u00e7in cevaplar ve f\u0131rsatlar sunarak g\u00fc\u00e7lendiricidir.<\/span><\/span><\/p>\n

“Kansere yakalanma konusunda genetik bir riske sahip olduklar\u0131n\u0131 \u00f6\u011frenen insanlar, korku ve endi\u015feden su\u00e7luluk ve \u00f6fkeye kadar \u00e7e\u015fitli duygusal tepkilere sahip olabilir. Kanserin kal\u0131tsal risklerini bilmek, kanserin neden yay\u0131ld\u0131\u011f\u0131na dair cevaplar \u015feklinde rahatl\u0131k sa\u011flayabilir. Umutlu ve g\u00fc\u00e7lendirici hissetmenin yan\u0131 s\u0131ra, hastalara kanseri erken evrelerde bulmak i\u00e7in daha yak\u0131ndan taranma, daha y\u00f6netilebilir veya baz\u0131 durumlarda kanseri tamamen \u00f6nlemek i\u00e7in ameliyat gibi ad\u0131mlar atma \u015fans\u0131 vermekle ilgilidir.” <\/span><\/span>Eric Fowler, sertifikal\u0131 genetik dan\u0131\u015fman<\/span><\/span><\/em><\/p><\/blockquote>\n

Basit\u00e7e s\u00f6ylemek gerekirse, kal\u0131tsal kanser sendromu, ailede g\u00f6r\u00fclen kanser riskidir. <\/span>Risk, nesilden nesile ge\u00e7en kusurlu veya mutasyona u\u011fram\u0131\u015f bir genden kaynaklan\u0131r. <\/span>Kal\u0131tsal kanser sendromlar\u0131, t\u00fcm kanser te\u015fhislerinin y\u00fczde 10’una kadar ili\u015fkilidir. <\/span>Sendromdan kaynaklanan kanser t\u00fcr\u00fc, kusurlu veya mutasyona u\u011fram\u0131\u015f gene ba\u011fl\u0131d\u0131r. <\/span>\u00d6rne\u011fin, kal\u0131tsal meme ve yumurtal\u0131k kanseri sendromuna BRCA1 ve\/veya BRCA2 genlerindeki mutasyonlar neden olur. <\/span>Bu sendrom, bir ki\u015finin meme, yumurtal\u0131k, prostat ve di\u011fer kanser t\u00fcrlerini geli\u015ftirme \u015fans\u0131n\u0131 b\u00fcy\u00fck \u00f6l\u00e7\u00fcde art\u0131r\u0131r. <\/span>TP53 genindeki bir mutasyonla karakterize edilen Li-Fraumeni sendromuna sahip ki\u015filerin 30’lu ya\u015flar\u0131nda kansere yakalanma riski y\u00fcksektir ve 60’l\u0131 ya\u015flar\u0131nda kansere yakalanma olas\u0131l\u0131\u011f\u0131 neredeyse kesindir.<\/span><\/span>\u00ae<\/span><\/span><\/sup> .<\/span><\/span><\/p>\n

En s\u0131k g\u00f6r\u00fclen sendromlar nelerdir?<\/span><\/span><\/h2>\n

Yayg\u0131n sendromlar ve ili\u015fkili kanserler:<\/span><\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
kanser sendromu<\/span><\/span><\/th>\ngenler<\/span><\/span><\/th>\nili\u015fkili kanserler<\/span><\/span><\/th>\n<\/tr>\n<\/thead>\n
Kal\u0131tsal meme kanseri ve yumurtal\u0131k kanseri sendromu<\/span><\/span><\/td>\nBRCA1 ve BRCA2<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/td>\nMeme, yumurtal\u0131k, prostat ve pankreas<\/span><\/span><\/td>\n<\/tr>\n
Li-Fraumeni sendromu<\/span><\/span><\/td>\nTP53<\/span><\/span><\/td>\nMeme, yumu\u015fak doku ve kemik sarkomu, l\u00f6semi, beyin ve adrenal kortikal karsinom<\/span><\/span><\/td>\n<\/tr>\n
Cowden sendromu<\/span><\/span><\/td>\nPTEN<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/td>\nMeme, tiroid ve endometrium<\/span><\/span><\/td>\n<\/tr>\n
Lynch sendromu<\/span><\/span><\/td>\nMSH2 \u060c MLH1 \u060c MSH6 \u060c PMS2 \u060c EPCAM<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/td>\nBa\u011f\u0131rsak, endometrium, yumurtal\u0131k, renal pelvis, pankreas, karaci\u011fer, mide, beyin, meme<\/span><\/span><\/td>\n<\/tr>\n
ailesel adenomat\u00f6z polipoz<\/span><\/span><\/td>\nAPC<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/td>\n\u0130yi huylu, k\u00f6t\u00fc huylu, k\u00f6t\u00fc huylu ba\u011f\u0131rsak, beyin, mide, kemik ve deri t\u00fcm\u00f6rleri<\/span><\/span><\/td>\n<\/tr>\n
retinoblastom<\/span><\/span><\/td>\nRB1<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/td>\nG\u00f6z (retina), melanom ve yumu\u015fak doku sarkomu<\/span><\/span><\/td>\n<\/tr>\n
\u00c7oklu endokrin neoplazi tip 2<\/span><\/span><\/td>\nemekli \u0648<\/span><\/span><\/td>\nTiroid bezi (medulla), adrenal bezin iyi huylu t\u00fcm\u00f6rleri<\/span><\/span><\/td>\n<\/tr>\n
von Hippel-Lindau sendromu<\/span><\/span><\/td>\nVHL<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/td>\nB\u00f6brek, \u00e7oklu kanserli olmayan t\u00fcm\u00f6rler<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Kaynak: Ulusal Kanser Enstit\u00fcs\u00fc<\/span><\/span><\/p>\n

\u00c7o\u011fu kanser sendromu te\u015fhisi konan hastalar mutlaka kanser geli\u015ftirmeyecektir. <\/span>Ancak sendromlar\u0131n\u0131n durumunu bilmek, kritik ad\u0131mlar atmalar\u0131n\u0131 sa\u011flayabilir: kanseri erken evrelerinde tespit etmeye yard\u0131mc\u0131 olur, kanser geli\u015fimini \u00f6nlemeye yard\u0131mc\u0131 olur ve sevdiklerinin m\u00fcteakip m\u00fcdahaleler hakk\u0131nda kendi kararlar\u0131n\u0131 vermelerine yard\u0131mc\u0131 olur. <\/span>\u00d6rne\u011fin baz\u0131 hastalar yo\u011fun tarama programlar\u0131n\u0131 tercih edebilir. <\/span>Meme kanseri riskini art\u0131ran sendromlar\u0131 olan hastalar, alt\u0131 ayda bir mamogram ve mamogram aras\u0131nda ge\u00e7i\u015f yapmaya karar verebilir. <\/span>Di\u011fer hastalar i\u00e7in daha \u015fiddetli koruyucu ameliyatlar tercih edilen se\u00e7enek olabilir.<\/span><\/span><\/p>\n

Philadelphia’daki hastanemizde y\u00fcksek riskli program\u0131 y\u00f6neten Korpman, “Birisi ameliyat\u0131 tercih etmeye haz\u0131r de\u011filse, de\u011ferlendirmeye ba\u015flamalar\u0131n\u0131 ve nas\u0131l gitti\u011fini g\u00f6rmelerini s\u00f6yl\u00fcyorum” diyor. <\/span>“Riskler ya\u015fla birlikte artar, bu nedenle 25 ya\u015f\u0131ndaki biri daha d\u00fc\u015f\u00fck risk alt\u0131ndad\u0131r ve isterse baz\u0131 kararlar\u0131 erteleyebilir.” <\/span>Aktris Angelina Jolie en agresif yolu se\u00e7ti. <\/span>BRCA1 meme kanseri mutasyonu oldu\u011funu \u00f6\u011frendikten sonra 2013 y\u0131l\u0131nda \u00f6nleyici \u00e7ift mastektomi ameliyat\u0131 ge\u00e7irdi\u011finde 37 ya\u015f\u0131ndayd\u0131. <\/span>Julie, The <\/span><\/span>New York Times’da<\/span><\/span><\/em> yazd\u0131 <\/span>. <\/span>Annesi 56 ya\u015f\u0131nda yumurtal\u0131k kanserinden \u00f6len Julie, daha sonra yumurtal\u0131klar\u0131n\u0131 ve fallop t\u00fcplerini ald\u0131rd\u0131.<\/span><\/span><\/p>\n

Kanser sendromundan \u015f\u00fcphelenilen bir\u00e7ok hasta i\u00e7in ana karar, tan\u0131y\u0131 do\u011frulamak i\u00e7in genetik test yapt\u0131rmakt\u0131r. <\/span>“Herhangi bir genetik test yapt\u0131rmadan bir sendromun klinik te\u015fhisini koyabilirsiniz. Ancak \u00e7o\u011fu durumda, baz\u0131 sendromlar\u0131 kesin olarak te\u015fhis etmenin tek yolu genetik testtir. Genetik testlerin sonu\u00e7lar\u0131, kanserin k\u00f6keninin gizemlerini \u00e7\u00f6zmeye yard\u0131mc\u0131 olabilir. Atalar , karde\u015fler ve \u00e7ocuklar kanser riskini art\u0131r\u0131r, Di\u011fer hastalar i\u00e7in tedavi kararlar\u0131n\u0131 \u015fekillendirmeye yard\u0131mc\u0131 olabilirler. \u00d6rne\u011fin, bir meme kanseri hastas\u0131 i\u00e7in, ailesel bir sendromunuz oldu\u011funun do\u011frulanmas\u0131, lumpektomi veya \u00e7ift mastektomi aras\u0131ndaki fark anlam\u0131na gelebilir. Ayr\u0131ca yumurtal\u0131k kanseri riskinizi belirlemenize yard\u0131mc\u0131 olur.<\/span><\/span><\/p>\n

Ne zaman test yapt\u0131rmal\u0131s\u0131n\u0131z?<\/span><\/span><\/h2>\n
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A\u015fa\u011f\u0131daki durumlarda genetik testi d\u00fc\u015f\u00fcnebilirsiniz:<\/span><\/span><\/p>\n

    \n
  • Kanserli birden fazla ebeveyn, karde\u015f veya torun.<\/span><\/span><\/li>\n
  • Ailenin bir taraf\u0131ndaki akrabalar ayn\u0131 kanser t\u00fcr\u00fcnden muzdarip<\/span><\/span><\/li>\n
  • Birden fazla kanser t\u00fcr\u00fc olan bir aile \u00fcyesi.<\/span><\/span><\/li>\n
  • Aile \u00fcyelerine erken ya\u015fta kanser te\u015fhisi kondu.<\/span><\/span><\/li>\n
  • Kal\u0131tsal kanser sendromu ile ili\u015fkili kanserleri olan aile \u00fcyeleri<\/span><\/span><\/li>\n
  • \u00c7ok nadir g\u00f6r\u00fclen kanserli bir aile \u00fcyesi.<\/span><\/span><\/li>\n
  • A\u015fkenazi Yahudisi veya Afrikal\u0131 Amerikal\u0131<\/span><\/span><\/li>\n
  • Bilinen bir genetik mutasyona sahip aile \u00fcyeleri<\/span><\/span><\/li>\n<\/ul>\n

    Corbman ve Fowler, hastalar\u0131n tedavi kararlar\u0131 vermeden \u00f6nce onkologlarla birlikte bir genetik dan\u0131\u015fmana dan\u0131\u015fmas\u0131n\u0131 tavsiye ediyor. <\/span>Korpman, “Yak\u0131n zamanda meme kanseri te\u015fhisi konan bir hastam vard\u0131. Bu y\u00fczden genetik testlerden elde edilen bilgilerin baz\u0131 cerrahi kararlar vermede nas\u0131l yard\u0131mc\u0131 olabilece\u011fi hakk\u0131nda konu\u015ftuk” diyor. <\/span>“Bir\u00e7ok hasta bu bilgiyi istedi\u011fini s\u00f6yl\u00fcyor. Ama bu hasta hen\u00fcz haz\u0131r de\u011fildi. O s\u0131rada kanser te\u015fhisinin kendisine yetti\u011fini s\u00f6yledi. Ameliyat olacak, tedavi olacak, ne zaman \u00e7\u0131kacakt\u0131. hepsini tamamlay\u0131n, testleri yapt\u0131r\u0131n ve bu \u00e7ok d\u00fcr\u00fcst bir cevapt\u0131.\u201d<\/span><\/span><\/p>\n<\/div>\n

    Genetik testler hakk\u0131nda daha fazla bilgi edinin<\/span><\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

    Kal\u0131tsal kanser riski CTCA Kanser, gelecek olmad\u0131\u011f\u0131n\u0131 bilmek m\u00fcmk\u00fcn de\u011fildir ne zaman ve v\u00fccudun hangi k\u0131sm\u0131nda. Ya\u015f, ya\u015fam tarz\u0131 se\u00e7imleri, \u00e7evresel maruziyet ve di\u011fer fakt\u00f6rlerle birlikte kanser riskleri artar, ancak bir\u00e7ok kanserin kesin nedenleri ve neden baz\u0131 insanlar\u0131 etkileyip di\u011ferlerini etkilemedi\u011fi bir s\u0131r olarak kal\u0131r. \u00d6rne\u011fin, ya\u015fam boyu sigara i\u00e7en bir ki\u015fi asla hastal\u0131\u011fa yakalanmayabilirken, …<\/p>\n","protected":false},"author":1,"featured_media":23349,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-24315","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-tr"],"yoast_head":"\nKal\u0131tsal kanser riski CTCA - zdmaa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zdmaa.com\/tr\/hereditary-cancer-risks-ctca\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Kal\u0131tsal kanser riski CTCA - zdmaa\" \/>\n<meta property=\"og:description\" content=\"Kal\u0131tsal kanser riski CTCA Kanser, gelecek olmad\u0131\u011f\u0131n\u0131 bilmek m\u00fcmk\u00fcn de\u011fildir ne zaman ve v\u00fccudun hangi k\u0131sm\u0131nda. Ya\u015f, ya\u015fam tarz\u0131 se\u00e7imleri, \u00e7evresel maruziyet ve di\u011fer fakt\u00f6rlerle birlikte kanser riskleri artar, ancak bir\u00e7ok kanserin kesin nedenleri ve neden baz\u0131 insanlar\u0131 etkileyip di\u011ferlerini etkilemedi\u011fi bir s\u0131r olarak kal\u0131r. \u00d6rne\u011fin, ya\u015fam boyu sigara i\u00e7en bir ki\u015fi asla hastal\u0131\u011fa yakalanmayabilirken, …\" \/>\n<meta property=\"og:url\" content=\"https:\/\/zdmaa.com\/tr\/hereditary-cancer-risks-ctca\/\" \/>\n<meta property=\"og:site_name\" content=\"zdmaa\" \/>\n<meta property=\"article:published_time\" content=\"2022-01-12T11:59:18+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-01-12T23:01:37+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/zdmaa.com\/wp-content\/uploads\/2022\/01\/skull-g085b924db_640.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"640\" \/>\n\t<meta property=\"og:image:height\" content=\"454\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Yazan:\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tahmini okuma s\u00fcresi\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 dakika\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/zdmaa.com\/tr\/hereditary-cancer-risks-ctca\/\",\"url\":\"https:\/\/zdmaa.com\/tr\/hereditary-cancer-risks-ctca\/\",\"name\":\"Kal\u0131tsal kanser riski CTCA - zdmaa\",\"isPartOf\":{\"@id\":\"https:\/\/zdmaa.com\/tr\/ro\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/zdmaa.com\/tr\/hereditary-cancer-risks-ctca\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/zdmaa.com\/tr\/hereditary-cancer-risks-ctca\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/zdmaa.com\/wp-content\/uploads\/2022\/01\/skull-g085b924db_640.jpg\",\"datePublished\":\"2022-01-12T11:59:18+00:00\",\"dateModified\":\"2022-01-12T23:01:37+00:00\",\"author\":{\"@id\":\"https:\/\/zdmaa.com\/tr\/ro\/#\/schema\/person\/8aad4cf5d562d4ca835487f6149853e3\"},\"breadcrumb\":{\"@id\":\"https:\/\/zdmaa.com\/tr\/hereditary-cancer-risks-ctca\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/zdmaa.com\/tr\/hereditary-cancer-risks-ctca\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/zdmaa.com\/tr\/hereditary-cancer-risks-ctca\/#primaryimage\",\"url\":\"https:\/\/zdmaa.com\/wp-content\/uploads\/2022\/01\/skull-g085b924db_640.jpg\",\"contentUrl\":\"https:\/\/zdmaa.com\/wp-content\/uploads\/2022\/01\/skull-g085b924db_640.jpg\",\"width\":640,\"height\":454,\"caption\":\"Hereditary cancer risks | CTCA\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/zdmaa.com\/tr\/hereditary-cancer-risks-ctca\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0629\",\"item\":\"https:\/\/zdmaa.com\/tr\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Kal\u0131tsal kanser riski CTCA\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/zdmaa.com\/tr\/ro\/#website\",\"url\":\"https:\/\/zdmaa.com\/tr\/ro\/\",\"name\":\"zdmaa\",\"description\":\"zdmaa\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/zdmaa.com\/tr\/ro\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"tr\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/zdmaa.com\/tr\/ro\/#\/schema\/person\/8aad4cf5d562d4ca835487f6149853e3\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/zdmaa.com\/tr\/ro\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/zdmaa.com\/wp-content\/litespeed\/avatar\/dff6d89ac221c1aaf9366bf5b4cd32de.jpg?ver=1775954700\",\"contentUrl\":\"https:\/\/zdmaa.com\/wp-content\/litespeed\/avatar\/dff6d89ac221c1aaf9366bf5b4cd32de.jpg?ver=1775954700\",\"caption\":\"admin\"},\"sameAs\":[\"https:\/\/zdmaa.com\"],\"url\":\"https:\/\/zdmaa.com\/tr\/author\/admin\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Kal\u0131tsal kanser riski CTCA - zdmaa","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/zdmaa.com\/tr\/hereditary-cancer-risks-ctca\/","og_locale":"tr_TR","og_type":"article","og_title":"Kal\u0131tsal kanser riski CTCA - zdmaa","og_description":"Kal\u0131tsal kanser riski CTCA Kanser, gelecek olmad\u0131\u011f\u0131n\u0131 bilmek m\u00fcmk\u00fcn de\u011fildir ne zaman ve v\u00fccudun hangi k\u0131sm\u0131nda. 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