{"id":24635,"date":"2022-01-12T13:49:46","date_gmt":"2022-01-12T10:49:46","guid":{"rendered":"https:\/\/zdmaa.com\/how-cancer-cells-find-ways-to-resist-treatment\/"},"modified":"2022-01-13T17:56:09","modified_gmt":"2022-01-13T14:56:09","slug":"how-cancer-cells-find-ways-to-resist-treatment","status":"publish","type":"post","link":"https:\/\/zdmaa.com\/tr\/how-cancer-cells-find-ways-to-resist-treatment\/","title":{"rendered":"Kanser h\u00fccreleri tedaviye direnmenin yollar\u0131n\u0131 nas\u0131l bulur?"},"content":{"rendered":"

Kanser h\u00fccreleri tedaviye direnmenin yollar\u0131n\u0131 nas\u0131l bulur?<\/span><\/span><\/span><\/span><\/p>\n

\n

Tedaviye diren\u00e7, hastalar i\u00e7in y\u0131k\u0131c\u0131 ve klinisyenler i\u00e7in sinir bozucudur ve bir\u00e7ok kanser t\u00fcr\u00fcnde \u00e7ok yayg\u0131nd\u0131r. <\/span>Bir hasta tedaviye haftalar, aylar veya bir y\u0131ldan uzun s\u00fcre olumlu yan\u0131t verebilir, ard\u0131ndan tedavinin art\u0131k iyi \u00e7al\u0131\u015fmad\u0131\u011f\u0131 veya t\u00fcm\u00f6r\u00fcn yeniden b\u00fcy\u00fcmeye ba\u015flad\u0131\u011f\u0131 bir duvara \u00e7arpabilir. <\/span>Philadelphia hastanemizdeki t\u0131bbi onkoloji \u015fefi ve t\u0131bbi ara\u015ft\u0131rma direkt\u00f6r\u00fc MD, MSEd, FACP Arturo Loaiza-Bonilla, \u201cBa\u015flang\u0131\u00e7ta, t\u00fcm\u00f6r tamamen gitti\u201d diyor. <\/span>“Fakat hareket etmeyen h\u00fccrelerin \u00e7ekirde\u011fine ula\u015ft\u0131\u011f\u0131n\u0131zda, bu h\u00fccrelerin diren\u00e7li oldu\u011funu ve b\u00fcy\u00fcmeye ba\u015flayacaklar\u0131n\u0131 anlayacaks\u0131n\u0131z. Bu \u00e7ok sinir bozucu.”<\/span><\/span><\/p>\n

“Hareket etmeyen h\u00fccrelerin \u00e7ekirde\u011fine ula\u015ft\u0131\u011f\u0131n\u0131zda, bu h\u00fccrelerin diren\u00e7li oldu\u011funu ve b\u00fcy\u00fcmeye ba\u015flayacaklar\u0131n\u0131 anlayacaks\u0131n\u0131z. Bu \u00e7ok sinir bozucu.” <\/span><\/span>– Arturo Loaiza-Bonilla, MD, MSED, FACP<\/span><\/span><\/em><\/p><\/blockquote>\n

Bir t\u00fcm\u00f6r bir\u00e7ok nedenden dolay\u0131 tedaviye diren\u00e7li olabilir. <\/span>Baz\u0131 durumlarda, t\u00fcm\u00f6r yap\u0131s\u0131 hemen hemen her zaman diren\u00e7li t\u00fcm\u00f6r h\u00fccreleri i\u00e7eriyordu, ancak genomik testler veya patolojik inceleme ile bile tespit edilmedi. <\/span>Ancak di\u011fer durumlarda kanser, ya do\u011fal seyrinin bir par\u00e7as\u0131 olarak ya da devam eden tedaviye yan\u0131t olarak yeni mutasyonlar geli\u015ftirerek veya koruyucu genleri \u00e7o\u011faltarak uyum sa\u011flar.<\/span><\/span><\/p>\n

Kanser mutasyonun s\u00fcr\u00fcc\u00fcs\u00fcn\u00fc de\u011fi\u015ftirdi\u011finde<\/span><\/span><\/h2>\n

Yenge\u00e7’i \u00f6n\u00fcn\u00fczde baz\u0131 engellerle yolda h\u0131zla ilerleyen bir otob\u00fcs olarak hayal edin. <\/span>Zamanla, yol boyunca yeni h\u00fccreler toplar ve yak\u0131t ikmali yapman\u0131n yollar\u0131n\u0131 bulur. <\/span>T\u0131bbi bir onkolog ve CTCA’n\u0131n t\u0131bbi direkt\u00f6r\u00fc olan Ashish Sangal, “O otob\u00fcs\u00fc s\u00fcren bir s\u00fcr\u00fcc\u00fc patlaman\u0131z var” diyor. <\/span><\/span>\u00ae<\/span><\/span><\/sup> Akci\u011fer Kanseri Merkezi Phoenix yak\u0131nlar\u0131ndaki hastanemizde. <\/span>S\u00fcr\u00fc\u015f mutasyonu, bu t\u00fcm\u00f6r\u00fcn h\u00fccrelerinde b\u00fcy\u00fcmelerine izin veren bask\u0131n genetik \u00f6zelliktir. <\/span>Bu s\u00fcr\u00fcc\u00fcy\u00fc tan\u0131mlayarak doktorlar, belirli mutasyonlar\u0131 hedefleyen bir antikanser ilac\u0131 e\u015fle\u015ftirebilir. <\/span>“S\u00fcr\u00fcc\u00fcy\u00fc tan\u0131mlamal\u0131 ve o s\u00fcr\u00fcc\u00fcy\u00fc hedef almal\u0131y\u0131z. Zamanla kontrol\u00fcn\u00fc kaybeder, gaz s\u00f6ner ve bazen otob\u00fcs \u00f6l\u00fcr.” <\/span>Di\u011fer zamanlarda, bir yolcu devral\u0131r ve yeni bir s\u00fcr\u00fcc\u00fc t\u00fcm\u00f6r\u00fcn hayatta kalmas\u0131na ve b\u00fcy\u00fcmesine izin verir. <\/span>Dr. Sangal, “Kanserin adapte oldu\u011fu yer buras\u0131d\u0131r ve yeni bir \u015fey denemeniz gerekir” diyor.<\/span><\/span><\/p>\n

Mutasyonlar mutasyon geli\u015ftirdi\u011finde<\/span><\/span><\/h2>\n

Sa\u011fl\u0131kl\u0131 h\u00fccreler, epidermal b\u00fcy\u00fcme fakt\u00f6r\u00fc resept\u00f6r\u00fc (EGFR) dahil olmak \u00fczere b\u00fcy\u00fcme ve b\u00f6l\u00fcnmeyi d\u00fczenlemeye yard\u0131mc\u0131 olmak i\u00e7in birka\u00e7 gene g\u00fcvenir. <\/span>Ancak bu gen mutasyona u\u011frad\u0131\u011f\u0131nda, t\u00fcm\u00f6rlerin olu\u015fmas\u0131na neden olan kontrols\u00fcz h\u00fccre b\u00fcy\u00fcmesine neden olabilir. <\/span>EGFR mutasyonuna sahip baz\u0131 kanserler, diren\u00e7 geli\u015fmeden birka\u00e7 ay \u00f6nce erlotinib ( <\/span><\/span>Tarceva\u00ae<\/span><\/span><\/sup> ), aftinib (Glotrif\u00ae <\/span><\/span>)<\/span><\/span><\/sup> veya gefitinib ( <\/span><\/span>Iressa\u00ae<\/span><\/span><\/sup> ) gibi hedefe y\u00f6nelik tedavi ila\u00e7lar\u0131na yan\u0131t verebilir . <\/span>Dr. Sangal, “Asl\u0131nda orijinal EGFR mutasyonunu koruyan ikinci bir mutasyonun geli\u015fimini g\u00f6rd\u00fck” diyor. <\/span>“Yani, birincil resept\u00f6r\u00fc hedef almaya devam etsek bile, bu yeni mutasyon onu engelliyor.” <\/span>Bu mutasyon osimertinib (Tagrisso\u00ae <\/span><\/span>)<\/span><\/span><\/sup> ile hedeflenebilir . <\/span>“\u0130\u015fte komisyon bu” diyen Dr. Sangal, bu mutasyonun zamanla tedaviye diren\u00e7li hale gelebilece\u011fini de s\u00f6zlerine ekledi.<\/span><\/span><\/p>\n

\u0130la\u00e7 asla kanser h\u00fccrelerine ula\u015fmad\u0131\u011f\u0131nda.<\/span><\/span><\/h2>\n

Ara\u015ft\u0131rmac\u0131lar, ila\u00e7 ta\u015f\u0131y\u0131c\u0131lar\u0131 olarak bilinen proteinler ve ila\u00e7lar\u0131 h\u00fccre i\u00e7ine ve d\u0131\u015f\u0131na ta\u015f\u0131yan enzimler hakk\u0131nda daha fazla \u015fey \u00f6\u011freniyorlar. <\/span>\u00d6nemli bir spesifik ta\u015f\u0131y\u0131c\u0131, Ulusal Kanser Enstit\u00fcs\u00fc taraf\u0131ndan yay\u0131nlanan bir makalede “at\u0131klar\u0131, yabanc\u0131 partik\u00fclleri ve toksinleri h\u00fccrelerden d\u0131\u015far\u0131 pompalayan \u00e7\u00f6p kanal\u0131” olarak tan\u0131mlanan P-glikoprotein (P-gp) adl\u0131 bir maddedir. <\/span>P-gp, h\u00fccreleri toksinlerden koruma ama\u00e7l\u0131d\u0131r, ancak ara\u015ft\u0131rmac\u0131lar ayr\u0131ca h\u00fccre \u00f6ld\u00fcr\u00fcc\u00fc olarak kabul edilen kemoterapi ila\u00e7lar\u0131n\u0131n ortadan kald\u0131r\u0131labilece\u011fini de belirlediler. <\/span>P-gp, \u00e7oklu ila\u00e7 direnci (MDR) gen ailesinin bir \u00fcyesidir. <\/span>Ara\u015ft\u0131rmac\u0131lar, gen amplifikasyonu ad\u0131 verilen bir s\u00fcre\u00e7te, baz\u0131 kanser h\u00fccrelerinin ila\u00e7 tedavilerini alt \u00fcst eden ve bunlar\u0131n \u00e7al\u0131\u015fmas\u0131n\u0131 engelleyen y\u00fczlerce MDR geni \u00fcretebilece\u011fine inan\u0131yor. <\/span>Baz\u0131 ara\u015ft\u0131rmac\u0131lar, P-gp’yi inhibe eden ila\u00e7lar geli\u015ftirmenin, terapilerin h\u00fccrelerin i\u00e7inde daha uzun s\u00fcre kalmas\u0131na izin vererek, onlara \u00e7al\u0131\u015fmak i\u00e7in daha fazla zaman verebilece\u011fine inan\u0131yor.<\/span><\/span><\/p>\n

Klinisyenler ve ara\u015ft\u0131rmac\u0131lar, terap\u00f6tik ila\u00e7lara kar\u015f\u0131 kanser direnciyle m\u00fccadele etmek i\u00e7in cesurca yeni yollar ar\u0131yorlar. <\/span>Devam eden ara\u015ft\u0131rmalar, mevcut ila\u00e7lar\u0131n hen\u00fcz hedef almad\u0131\u011f\u0131 genetik \u00f6zellikleri hedef almak i\u00e7in tasarlanm\u0131\u015f potansiyel yeni tedavileri ara\u015ft\u0131r\u0131yor. <\/span>\u0130la\u00e7 kombinasyonlar\u0131n\u0131n, ayn\u0131 anda veya art arda birden fazla hedefe sald\u0131rmak i\u00e7in ba\u015fka bir se\u00e7enek oldu\u011fu kan\u0131tlanm\u0131\u015ft\u0131r. <\/span>Dr. Sangal, “Kansere bir\u00e7ok farkl\u0131 y\u00f6nden sald\u0131r\u0131yoruz” diyor. <\/span>“Burada klinik deneyler devreye giriyor. Kanseri elimizdekilerle tedavi ediyoruz, ancak en iyi sonu\u00e7lar\u0131 almak i\u00e7in bu tedaviye ne ekleyebiliriz?”<\/span><\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Kanser h\u00fccreleri tedaviye direnmenin yollar\u0131n\u0131 nas\u0131l bulur? Tedaviye diren\u00e7, hastalar i\u00e7in y\u0131k\u0131c\u0131 ve klinisyenler i\u00e7in sinir bozucudur ve bir\u00e7ok kanser t\u00fcr\u00fcnde \u00e7ok yayg\u0131nd\u0131r. Bir hasta tedaviye haftalar, aylar veya bir y\u0131ldan uzun s\u00fcre olumlu yan\u0131t verebilir, ard\u0131ndan tedavinin art\u0131k iyi \u00e7al\u0131\u015fmad\u0131\u011f\u0131 veya t\u00fcm\u00f6r\u00fcn yeniden b\u00fcy\u00fcmeye ba\u015flad\u0131\u011f\u0131 bir duvara \u00e7arpabilir. Philadelphia hastanemizdeki t\u0131bbi onkoloji \u015fefi ve …<\/p>\n","protected":false},"author":1,"featured_media":23186,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-24635","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-tr"],"yoast_head":"\nKanser h\u00fccreleri tedaviye direnmenin yollar\u0131n\u0131 nas\u0131l bulur? - zdmaa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zdmaa.com\/tr\/how-cancer-cells-find-ways-to-resist-treatment\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Kanser h\u00fccreleri tedaviye direnmenin yollar\u0131n\u0131 nas\u0131l bulur? - zdmaa\" \/>\n<meta property=\"og:description\" content=\"Kanser h\u00fccreleri tedaviye direnmenin yollar\u0131n\u0131 nas\u0131l bulur? Tedaviye diren\u00e7, hastalar i\u00e7in y\u0131k\u0131c\u0131 ve klinisyenler i\u00e7in sinir bozucudur ve bir\u00e7ok kanser t\u00fcr\u00fcnde \u00e7ok yayg\u0131nd\u0131r. Bir hasta tedaviye haftalar, aylar veya bir y\u0131ldan uzun s\u00fcre olumlu yan\u0131t verebilir, ard\u0131ndan tedavinin art\u0131k iyi \u00e7al\u0131\u015fmad\u0131\u011f\u0131 veya t\u00fcm\u00f6r\u00fcn yeniden b\u00fcy\u00fcmeye ba\u015flad\u0131\u011f\u0131 bir duvara \u00e7arpabilir. Philadelphia hastanemizdeki t\u0131bbi onkoloji \u015fefi ve …\" \/>\n<meta property=\"og:url\" content=\"https:\/\/zdmaa.com\/tr\/how-cancer-cells-find-ways-to-resist-treatment\/\" \/>\n<meta property=\"og:site_name\" content=\"zdmaa\" \/>\n<meta property=\"article:published_time\" content=\"2022-01-12T10:49:46+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-01-13T14:56:09+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/zdmaa.com\/wp-content\/uploads\/2022\/01\/lab-g3981e51de_640.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"640\" \/>\n\t<meta property=\"og:image:height\" content=\"426\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Yazan:\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tahmini okuma s\u00fcresi\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 dakika\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/zdmaa.com\/tr\/how-cancer-cells-find-ways-to-resist-treatment\/\",\"url\":\"https:\/\/zdmaa.com\/tr\/how-cancer-cells-find-ways-to-resist-treatment\/\",\"name\":\"Kanser h\u00fccreleri tedaviye direnmenin yollar\u0131n\u0131 nas\u0131l bulur? - zdmaa\",\"isPartOf\":{\"@id\":\"https:\/\/zdmaa.com\/tr\/ro\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/zdmaa.com\/tr\/how-cancer-cells-find-ways-to-resist-treatment\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/zdmaa.com\/tr\/how-cancer-cells-find-ways-to-resist-treatment\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/zdmaa.com\/wp-content\/uploads\/2022\/01\/lab-g3981e51de_640.jpg\",\"datePublished\":\"2022-01-12T10:49:46+00:00\",\"dateModified\":\"2022-01-13T14:56:09+00:00\",\"author\":{\"@id\":\"https:\/\/zdmaa.com\/tr\/ro\/#\/schema\/person\/8aad4cf5d562d4ca835487f6149853e3\"},\"breadcrumb\":{\"@id\":\"https:\/\/zdmaa.com\/tr\/how-cancer-cells-find-ways-to-resist-treatment\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/zdmaa.com\/tr\/how-cancer-cells-find-ways-to-resist-treatment\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/zdmaa.com\/tr\/how-cancer-cells-find-ways-to-resist-treatment\/#primaryimage\",\"url\":\"https:\/\/zdmaa.com\/wp-content\/uploads\/2022\/01\/lab-g3981e51de_640.jpg\",\"contentUrl\":\"https:\/\/zdmaa.com\/wp-content\/uploads\/2022\/01\/lab-g3981e51de_640.jpg\",\"width\":640,\"height\":426,\"caption\":\"How Cancer Cells Find Ways to Resist Treatment\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/zdmaa.com\/tr\/how-cancer-cells-find-ways-to-resist-treatment\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0629\",\"item\":\"https:\/\/zdmaa.com\/tr\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Kanser h\u00fccreleri tedaviye direnmenin yollar\u0131n\u0131 nas\u0131l bulur?\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/zdmaa.com\/tr\/ro\/#website\",\"url\":\"https:\/\/zdmaa.com\/tr\/ro\/\",\"name\":\"zdmaa\",\"description\":\"zdmaa\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/zdmaa.com\/tr\/ro\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"tr\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/zdmaa.com\/tr\/ro\/#\/schema\/person\/8aad4cf5d562d4ca835487f6149853e3\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/zdmaa.com\/tr\/ro\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/zdmaa.com\/wp-content\/litespeed\/avatar\/dff6d89ac221c1aaf9366bf5b4cd32de.jpg?ver=1777164375\",\"contentUrl\":\"https:\/\/zdmaa.com\/wp-content\/litespeed\/avatar\/dff6d89ac221c1aaf9366bf5b4cd32de.jpg?ver=1777164375\",\"caption\":\"admin\"},\"sameAs\":[\"https:\/\/zdmaa.com\"],\"url\":\"https:\/\/zdmaa.com\/tr\/author\/admin\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Kanser h\u00fccreleri tedaviye direnmenin yollar\u0131n\u0131 nas\u0131l bulur? - zdmaa","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/zdmaa.com\/tr\/how-cancer-cells-find-ways-to-resist-treatment\/","og_locale":"tr_TR","og_type":"article","og_title":"Kanser h\u00fccreleri tedaviye direnmenin yollar\u0131n\u0131 nas\u0131l bulur? - zdmaa","og_description":"Kanser h\u00fccreleri tedaviye direnmenin yollar\u0131n\u0131 nas\u0131l bulur? Tedaviye diren\u00e7, hastalar i\u00e7in y\u0131k\u0131c\u0131 ve klinisyenler i\u00e7in sinir bozucudur ve bir\u00e7ok kanser t\u00fcr\u00fcnde \u00e7ok yayg\u0131nd\u0131r. Bir hasta tedaviye haftalar, aylar veya bir y\u0131ldan uzun s\u00fcre olumlu yan\u0131t verebilir, ard\u0131ndan tedavinin art\u0131k iyi \u00e7al\u0131\u015fmad\u0131\u011f\u0131 veya t\u00fcm\u00f6r\u00fcn yeniden b\u00fcy\u00fcmeye ba\u015flad\u0131\u011f\u0131 bir duvara \u00e7arpabilir. Philadelphia hastanemizdeki t\u0131bbi onkoloji \u015fefi ve …","og_url":"https:\/\/zdmaa.com\/tr\/how-cancer-cells-find-ways-to-resist-treatment\/","og_site_name":"zdmaa","article_published_time":"2022-01-12T10:49:46+00:00","article_modified_time":"2022-01-13T14:56:09+00:00","og_image":[{"width":640,"height":426,"url":"https:\/\/zdmaa.com\/wp-content\/uploads\/2022\/01\/lab-g3981e51de_640.jpg","type":"image\/jpeg"}],"author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Yazan:":"admin","Tahmini okuma s\u00fcresi":"4 dakika"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/zdmaa.com\/tr\/how-cancer-cells-find-ways-to-resist-treatment\/","url":"https:\/\/zdmaa.com\/tr\/how-cancer-cells-find-ways-to-resist-treatment\/","name":"Kanser h\u00fccreleri tedaviye direnmenin yollar\u0131n\u0131 nas\u0131l bulur? - zdmaa","isPartOf":{"@id":"https:\/\/zdmaa.com\/tr\/ro\/#website"},"primaryImageOfPage":{"@id":"https:\/\/zdmaa.com\/tr\/how-cancer-cells-find-ways-to-resist-treatment\/#primaryimage"},"image":{"@id":"https:\/\/zdmaa.com\/tr\/how-cancer-cells-find-ways-to-resist-treatment\/#primaryimage"},"thumbnailUrl":"https:\/\/zdmaa.com\/wp-content\/uploads\/2022\/01\/lab-g3981e51de_640.jpg","datePublished":"2022-01-12T10:49:46+00:00","dateModified":"2022-01-13T14:56:09+00:00","author":{"@id":"https:\/\/zdmaa.com\/tr\/ro\/#\/schema\/person\/8aad4cf5d562d4ca835487f6149853e3"},"breadcrumb":{"@id":"https:\/\/zdmaa.com\/tr\/how-cancer-cells-find-ways-to-resist-treatment\/#breadcrumb"},"inLanguage":"tr","potentialAction":[{"@type":"ReadAction","target":["https:\/\/zdmaa.com\/tr\/how-cancer-cells-find-ways-to-resist-treatment\/"]}]},{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/zdmaa.com\/tr\/how-cancer-cells-find-ways-to-resist-treatment\/#primaryimage","url":"https:\/\/zdmaa.com\/wp-content\/uploads\/2022\/01\/lab-g3981e51de_640.jpg","contentUrl":"https:\/\/zdmaa.com\/wp-content\/uploads\/2022\/01\/lab-g3981e51de_640.jpg","width":640,"height":426,"caption":"How Cancer Cells Find Ways to Resist Treatment"},{"@type":"BreadcrumbList","@id":"https:\/\/zdmaa.com\/tr\/how-cancer-cells-find-ways-to-resist-treatment\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0629","item":"https:\/\/zdmaa.com\/tr\/"},{"@type":"ListItem","position":2,"name":"Kanser h\u00fccreleri tedaviye direnmenin yollar\u0131n\u0131 nas\u0131l bulur?"}]},{"@type":"WebSite","@id":"https:\/\/zdmaa.com\/tr\/ro\/#website","url":"https:\/\/zdmaa.com\/tr\/ro\/","name":"zdmaa","description":"zdmaa","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/zdmaa.com\/tr\/ro\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"tr"},{"@type":"Person","@id":"https:\/\/zdmaa.com\/tr\/ro\/#\/schema\/person\/8aad4cf5d562d4ca835487f6149853e3","name":"admin","image":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/zdmaa.com\/tr\/ro\/#\/schema\/person\/image\/","url":"https:\/\/zdmaa.com\/wp-content\/litespeed\/avatar\/dff6d89ac221c1aaf9366bf5b4cd32de.jpg?ver=1777164375","contentUrl":"https:\/\/zdmaa.com\/wp-content\/litespeed\/avatar\/dff6d89ac221c1aaf9366bf5b4cd32de.jpg?ver=1777164375","caption":"admin"},"sameAs":["https:\/\/zdmaa.com"],"url":"https:\/\/zdmaa.com\/tr\/author\/admin\/"}]}},"_links":{"self":[{"href":"https:\/\/zdmaa.com\/tr\/wp-json\/wp\/v2\/posts\/24635","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zdmaa.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zdmaa.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zdmaa.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/zdmaa.com\/tr\/wp-json\/wp\/v2\/comments?post=24635"}],"version-history":[{"count":1,"href":"https:\/\/zdmaa.com\/tr\/wp-json\/wp\/v2\/posts\/24635\/revisions"}],"predecessor-version":[{"id":24656,"href":"https:\/\/zdmaa.com\/tr\/wp-json\/wp\/v2\/posts\/24635\/revisions\/24656"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/zdmaa.com\/tr\/wp-json\/wp\/v2\/media\/23186"}],"wp:attachment":[{"href":"https:\/\/zdmaa.com\/tr\/wp-json\/wp\/v2\/media?parent=24635"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zdmaa.com\/tr\/wp-json\/wp\/v2\/categories?post=24635"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zdmaa.com\/tr\/wp-json\/wp\/v2\/tags?post=24635"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}